Protein Alignment CG2321 and C2orf42

DIOPT Version :9

• Sequence 1: NP_001263068.1
• Gene: CG2321 / 43471
• FlyBaseID: FBgn0039663
• Length: 643
• Species: Drosophila melanogaster
• Sequence 2: NP_001335687.1
• Gene: C2orf42 / 54980
• HGNCID: 26056
• Length: 574
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 149/698 - (21%)
• Similarity: 246/698 - (35%)
• Gaps: 217/698 - (31%)

  Fly     1 MRGVRKCVHCGAINGNRALLCKNSEC-------PQRRNVLDAVQLVSLRPGS--TVYSLRTKEKE 56
            :||:|||..||..||.|.|.|||..|       .:::..::||::::   ||  .|||:|.:::.
Human    22 LRGIRKCPRCGTYNGTRGLSCKNKTCGTIFRYGARKQPSVEAVKIIT---GSDLQVYSVRQRDRG 83

  Fly    57 QQPRNFVVIQDVTLSLQP-DAAVVS--SKAECFVESCKRT---GGEPTDCVHVKACRELGAEFAK 115
            ...|.||.:.....::|. |..:::  |...|:|.||.:.   |.....|.|:|......||
Human    84 PDYRCFVELGVSETTIQTVDGTIITQLSSGRCYVPSCLKAATQGVVENQCQHIKLAVNCQAE--- 145

  Fly   116 AQVYRVSREVLWNLNISLEQKQNLWQLYKYAEEEEHLPGVQRLNHSTFAVKCERSESFPAARLHV 180
            |....:...||..:..|.|.||.:|||    ..|...|.|||:..:...|||:.|:......||.
Human   146 ATPLTLKSSVLNAMQASPETKQTIWQL----ATEPTGPLVQRITKNILVVKCKASQKHSLGYLHT 206

  Fly   181 T----VSANGLSKKKSSYACACRKLKIIVEPDNSLVMQDEI---CDHLLLVLAGILSSPQGKRVY 238
            :    ||...|.:::  :.|:|:.||    ...|...:||.   |.|....:....|.....:.:
Human   207 SFVQKVSGKSLPERR--FFCSCQTLK----SHKSNASKDETAQRCIHFFACICAFASDETLAQEF 265

  Fly   239 GHF----TSGLQTFWMPLQLETPLGDVATEDLRLSLDMVDELDPQVDILVFGDQLDLSLPNLSDG 299
            ..|    :|||:                                           ::.:|.|  |
Human   266 SDFLNFDSSGLK-------------------------------------------EIIVPQL--G 285

  Fly   300 VFNLDTMQA--ATSSQSASSTNDALIHYANDSQLLSNLDVYAEPIELTDCNIELMDQFQPTDQLD 362
            ..:..|:.|  :|:|:|.....|.:.....:|.||                        |.|
Human   286 CHSESTVSACESTASKSKKRRKDEVSGAQMNSSLL------------------------PQD--- 323

  Fly   363 ICSEDIELPLISEPYNILAAPPIFTEATPSVVADQLPIELATISMVKKAPVKFSEIVTEVKSLKQ 427
                                                    |..|.::|:.:|...:.:.:|
Human   324 ----------------------------------------AVSSNLRKSGLKKPVVASSLK---- 344

  Fly   428 PSLPAKRELIVNGAASAASACLDASVQPALSYSAWLDHVIELLNDSC--------EPLETESNTL 484
                          ..|....|| ..|..||:..||..|.|.::.:.        |||.
Human   345 --------------RQACGQLLD-EAQVTLSFQDWLASVTERIHQTMHYQFDGKPEPLV------ 388

  Fly   485 TKRLVQQNFHVHKETFSHFCKSFSTGVKRRPLDKLTVIESGKHK----GLSKYTWHFASPHTAKR 545
                    ||:.:..|....:..|.|..::.|...|.....|..    ..||||||..:....|:
Human   389 --------FHIPQSFFDALQQRISIGSAKKRLPNSTTAFVRKDALPLGTFSKYTWHITNILQVKQ 445

  Fly   546 IFSTSNVQLQLDRAFERHAEGHFVPYVRPPME----PQVPGQPKKRIVYPRLSLYMVKILFEAAP 606
            |..|..:.|::.|:|.::.:|.:..:..|.:|    .:..|:.:|:.|...|.|.....:...:|
Human   446 ILDTPEMPLEITRSFIQNRDGTYELFKCPKVEVESIAETYGRIEKQPVLRPLELKTFLKVGNTSP 510

  Fly   607 KDYVGNGVLVTWTPDVLPRSQFGLMHVEFTV------------ETRPP 642
            ........::.|.||:||:|:.|.:.::|..            :.|||
Human   511 DQKEPTPFIIEWIPDILPQSKIGELRIKFEYGHHRNGHVAEYQDQRPP 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2321	NP_001263068.1	zf-tcix	2..35	CDD:291613	15/39 (38%)
C2orf42	NP_001335687.1	zf-tcix	16..57	CDD:405620	15/34 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155200
Domainoid	1	1.000	121	1.000	Domainoid score	I5736
eggNOG	1	0.900	-	-		E1_28WW6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4417
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D175787at33208
OrthoFinder	1	1.000	-	-		FOG0006324
OrthoInspector	1	1.000	-	-		oto89734
orthoMCL	1	0.900	-	-		OOG6_109867
Panther	1	1.100	-	-	LDO	PTHR13518
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5329
SonicParanoid	1	1.000	-	-		X4601
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790