DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Obsl1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006496646.2	Gene:	Obsl1 / 98733	MGIID:	2138628	Length:	1896	Species:	Mus musculus

Alignment Length:	1069	Identity:	191/1069 - (17%)
Similarity:	315/1069 - (29%)	Gaps:	408/1069 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GFVL-----------LLILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGV--NEHSLVD 70
            ||||           |.:.|.  ...||:......| :||   |.....|.|...|  .||.:|
Mouse   301 GFVLKVLYCQAKDRGLYVCAA--RNSAGQTLSAVQL-HVK---EPRLRFTRPLQDVEGREHGIV- 358

  Fly    71 TLVWKTASTTI--AQFANRIPLLHSPRIQLLSDNF--GLQFSPSLASDTSEYICLVNDRHIPEAI 131
            .|..|..::.|  |.|.....||...:.:.:.:..  .|......|.|...|:|.:..|  ...:
Mouse   359 VLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGAVRRLVIHKLKADDDGVYLCEMRGR--VRTV 421

  Fly   132 VDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTH-----FIIETRE-GEDGIWEQLA 190
            .::.|:.       |:|              .:.||...|..     .::||:| |..|.|.:..
Mouse   422 ANVTVKG-------PIL--------------KRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDG 465

  Fly   191 RIYTKTNATS------YQVTGLT-------PFTVYSFR---LLAVNKLGISPPSKESYYIVTLRE 239
            .....|..:|      ..:.|:|       .|::.:.|   ||.|..:..|||
Mouse   466 EDLPDTCQSSCGHMHALVLPGVTREDAGEITFSLGNSRTTTLLRVKCVKHSPP------------ 518

  Fly   240 APTGKPIPTTAHNTSSTSVYISWK--APPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVE 302
               |.|:...........|.::||  .|||:|   .|: ||:          :.:|:. .|:.::
Mouse   519 ---GPPVMVEMFKGQKNKVLLTWKPPEPPPET---SFI-YRL----------ERQEVG-SDDWIQ 565

  Fly   303 SHEIQN----------LQTYTQYKVTVQVFNPEGLGPE-----------TTILV--MTDEGVPSK 344
            ...|:.          :.|...|...:...:..|..|.           |..||  :.|..|...
Mouse   566 CFSIEKAGAVEVPGDCVPTEGDYHFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLEDVQVYDG 630

  Fly   345 PQNLTILDVSANSITMSW---------HPPKNQ----------------------------NGAI 372
            ...:..||:|| .|..||         :.|:.|                            :||:
Mouse   631 EDAVFSLDLSA-IIQGSWFLNGEQLQSNEPEGQVEPGALRYRIEQKGLQHRLILQAVKHRDSGAL 694

  Fly   373 AGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIV------------------- 418
            .|:....:.|:..    :....:||..|...:..:|...|..||::
Mouse   695 VGFSCPGVQDSAA----LTIQESSVHILSPQDKVSLTFTTSERVVLTCELSRVDFPATWYKDGQK 755

  Fly   419 ----KAFTTKNEGEPSDQI---AQRTDVG-------GPSA--------PAI-------------- 447
                ::...|.||.....|   ||..|.|       |.||        |.:
Mouse   756 VEESESLIVKTEGRKHRLILPEAQVRDSGEFECRTEGVSAFFGVTVQDPPVHIVNPQEHVFVHAI 820

  Fly   448 ----VNLTCH-SQESITIRWRRPYEFYNTIDFYIIKTR---------------------LAGQD- 485
                |.|||. .:|..|:.|.:..:.....|..:::.:                     :||.:
Mouse   821 TSECVRLTCEVDREDTTVHWYKDGQEVEESDIIVLENKGPHHRLVLPAARPSDGGEFQCVAGDER 885

  Fly   486 -----THRDI---------RINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKF 536
                 |..|:         .::.:|..||..::...| ...:.||:.......|:....::|.|.
Mouse   886 AYFTVTITDVFSWIVYPSSEVHVAAVRLERVVLTCEL-CRPWAEVRWTKDGEEVVESPALLLEKE 949

  Fly   537 SESR-----IIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAY 596
            ...|     .:||:.:.|.|..:..:|              :.|.|.
Mouse   950 DTIRRLVLPSVQLEDSGEYLCEIHDES--------------ASFTIT------------------ 982

  Fly   597 YYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISD 661
              :.:||                   :|...|.:|...|..||                 ||:.
Mouse   983 --VTEPP-------------------VRIIYPQDEVTLHAVSL-----------------ECVV- 1008

  Fly   662 DLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPL 726
             |.||.|:  |:.....|.:....:.|...:..:.|.::.|....|...||.:    |:...|
Mouse  1009 -LTCELSR--EDAPVRWYKDGLEVEESEALVLQSDGPRRRLVLPAAQPEDGGE----FVCDAG-- 1064

  Fly   727 PDTFDCFWRMIWEQRVAIIVMIT----NLVERGRRKCDMY---------------------WPKD 766
                        :......|.:|    .:|....|..|:.                     |.||
Mouse  1065 ------------DDSAFFTVTVTAPPERIVHPAARSLDLQFGAPGHVELRCEVAPAGSQVRWYKD 1117

  Fly   767 GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQ--CNT--EKLVYQYHYTNWPDHGTPDH 827
            |:|......::|..|.     ..|||.:.|.:.:...:  |.|  |.:.:.......|
Mouse  1118 GLEVEVSDALQLGAEG-----PARTLTLPHAQPEDAGEYVCETRDEAVTFNVSLAELP------- 1170

  Fly   828 PLPVLNFVKKSSAANP---AEAGPIVVHC 853
                :.|:...:|.||   ....|:|:.|
Mouse  1171 ----VQFLAPEAAPNPLCVVPGEPVVLSC 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	23/117 (20%)
		fn3	249..331	CDD:278470	17/104 (16%)
		FN3	342..437	CDD:238020	26/157 (17%)
		FN3	442..520	CDD:238020	21/140 (15%)
		PTPc	646..911	CDD:214550	43/240 (18%)
		PTPc	676..911	CDD:238006	36/210 (17%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Obsl1	XP_006496646.2	I-set	12..88	CDD:400151
		Ig strand B	29..33	CDD:409353
		Ig strand C	42..46	CDD:409353
		Ig strand E	67..71	CDD:409353
		Ig strand F	81..86	CDD:409353
		IG	134..226	CDD:214652
		Ig strand A'	252..257	CDD:409353
		Ig	257..336	CDD:416386	9/37 (24%)
		Ig strand B	262..269	CDD:409353
		Ig strand C	276..282	CDD:409353
		Ig strand C'	283..286	CDD:409353
		Ig strand D	292..298	CDD:409353
		Ig strand E	301..311	CDD:409353	4/9 (44%)
		Ig strand F	315..323	CDD:409353	2/9 (22%)
		Ig strand G	325..336	CDD:409353	3/11 (27%)
		Ig	342..426	CDD:416386	19/86 (22%)
		Ig strand B	358..362	CDD:409353	2/4 (50%)
		Ig strand C	371..374	CDD:409353	1/2 (50%)
		Ig strand E	395..399	CDD:409353	1/3 (33%)
		Ig strand F	409..414	CDD:409353	2/4 (50%)
		Ig strand G	423..426	CDD:409353	0/2 (0%)
		FN3	518..602	CDD:238020	19/113 (17%)
		Ig	736..801	CDD:416386	11/64 (17%)
		Ig strand C	746..751	CDD:409353	0/4 (0%)
		Ig strand C'	754..757	CDD:409353	0/2 (0%)
		Ig strand D	762..767	CDD:409353	1/4 (25%)
		Ig strand E	770..775	CDD:409353	0/4 (0%)
		Ig strand F	784..790	CDD:409353	1/5 (20%)
		Ig strand G	793..801	CDD:409353	2/7 (29%)
		Ig	825..892	CDD:416386	10/66 (15%)
		Ig strand B	825..830	CDD:409353	3/4 (75%)
		Ig strand C	837..842	CDD:409353	2/4 (50%)
		Ig strand C'	845..848	CDD:409353	0/2 (0%)
		Ig strand D	853..858	CDD:409353	0/4 (0%)
		Ig strand E	861..866	CDD:409353	0/4 (0%)
		Ig strand F	875..881	CDD:409353	0/5 (0%)
		Ig strand G	884..892	CDD:409353	0/7 (0%)
		Ig	918..983	CDD:416386	14/99 (14%)
		Ig strand C	928..933	CDD:409353	2/4 (50%)
		Ig strand C'	936..939	CDD:409353	0/2 (0%)
		Ig strand D	944..949	CDD:409353	1/4 (25%)
		Ig strand E	952..957	CDD:409353	1/4 (25%)
		Ig strand F	966..972	CDD:409353	2/5 (40%)
		Ig strand G	975..983	CDD:409353	3/41 (7%)
		Ig	1009..1074	CDD:416386	15/84 (18%)
		Ig strand C	1019..1024	CDD:409353	0/4 (0%)
		Ig strand C'	1027..1030	CDD:409353	0/2 (0%)
		Ig strand D	1035..1040	CDD:409353	0/4 (0%)
		Ig strand E	1043..1048	CDD:409353	1/4 (25%)
		Ig strand F	1057..1063	CDD:409353	1/9 (11%)
		Ig strand G	1066..1074	CDD:409353	1/7 (14%)
		Ig	1096..1166	CDD:416386	14/74 (19%)
		Ig strand B	1099..1104	CDD:409353	0/4 (0%)
		Ig strand C	1111..1116	CDD:409353	1/4 (25%)
		Ig strand C'	1119..1122	CDD:409353	1/2 (50%)
		Ig strand D	1127..1132	CDD:409353	1/4 (25%)
		Ig strand E	1135..1140	CDD:409353	3/4 (75%)
		Ig strand F	1149..1155	CDD:409353	1/5 (20%)
		Ig strand G	1158..1166	CDD:409353	1/7 (14%)
		Ig	1179..1265	CDD:416386	6/17 (35%)
		Ig strand A	1179..1184	CDD:409353	3/4 (75%)
		Ig strand B	1188..1196	CDD:409353	3/8 (38%)
		Ig strand C	1202..1208	CDD:409353
		Ig strand C'	1210..1213	CDD:409353
Ig strand D	1218..1222	CDD:409353
Ig strand E	1228..1235	CDD:409353
Ig strand F	1241..1250	CDD:409353
Ig strand G	1252..1265	CDD:409353
Ig	1273..1354	CDD:416386
Ig strand A	1273..1275	CDD:409353
Ig strand A'	1278..1282	CDD:409353
Ig strand B	1286..1292	CDD:409353
Ig strand C	1299..1304	CDD:409353
Ig strand C'	1307..1310	CDD:409353
Ig strand D	1315..1320	CDD:409353
Ig strand E	1323..1328	CDD:409353
Ig strand F	1337..1343	CDD:409353
Ig strand G	1346..1354	CDD:409353
Ig	1361..1444	CDD:416386
Ig strand B	1376..1383	CDD:409353
Ig strand C	1389..1395	CDD:409353
Ig strand C'	1396..1399	CDD:409353
Ig strand D	1405..1410	CDD:409353
Ig strand E	1413..1423	CDD:409353
Ig strand G	1433..1444	CDD:409353
Ig	1451..1522	CDD:416386
Ig strand A'	1458..1461	CDD:409353
Ig strand B	1465..1471	CDD:409353
Ig strand C	1480..1485	CDD:409353
Ig strand C'	1488..1491	CDD:409353
Ig strand D	1496..1501	CDD:409353
Ig strand E	1504..1509	CDD:409353
Ig strand F	1518..1524	CDD:409353
Ig strand G	1527..1535	CDD:409353
Ig	1543..1624	CDD:416386
Ig strand A'	1549..1552	CDD:409353
Ig strand B	1556..1562	CDD:409353
Ig strand C	1569..1574	CDD:409353
Ig strand C'	1577..1580	CDD:409353
Ig strand D	1585..1590	CDD:409353
Ig strand E	1593..1598	CDD:409353
Ig strand F	1607..1613	CDD:409353
Ig strand G	1616..1624	CDD:409353
Ig	1631..1714	CDD:416386
Ig strand B	1645..1651	CDD:409353
Ig strand C	1658..1663	CDD:409353
Ig strand C'	1666..1669	CDD:409353
Ig strand D	1674..1679	CDD:409353
Ig strand E	1682..1687	CDD:409353
Ig strand F	1696..1702	CDD:409353
Ig	1720..1803	CDD:416386
Ig strand A'	1725..1730	CDD:409353
Ig strand B	1735..1742	CDD:409353
Ig strand C	1746..1754	CDD:409353
Ig strand C'	1755..1758	CDD:409353
Ig strand D	1764..1769	CDD:409353
Ig strand E	1772..1782	CDD:409353
Ig strand G	1792..1803	CDD:409353
IG_like	1815..1893	CDD:214653
Ig strand B	1826..1830	CDD:409353
Ig strand C	1838..1842	CDD:409353
Ig strand E	1863..1867	CDD:409353
Ig strand F	1877..1882	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900