DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptprr

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_446046.2	Gene:	Ptprr / 94202	RGDID:	620780	Length:	656	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	191/766 - (24%)
Similarity:	308/766 - (40%)	Gaps:	209/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 SKESYYIVTLREAPTGKPIPTTAHNTS-STSVYISWKA-----PPPDTILGEFLGYRITYR---- 282
            |:.:.:.:.:|:..:.||:....|:.. ..|:.|:.:|     |.|..:       :|:.|
  Rat    23 SRNNDHFLAIRQKKSWKPMFIYDHSQDIKKSLDIAQEAYKHNYPAPSEV-------QISKRHQIV 80

  Fly   283 ----PRDR-DPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVP 342
                ||.. ||:    :.:...:.:..||:||..                 |...::|:|.: :.
  Rat    81 DSAFPRPAYDPS----LNLLAASGQDLEIENLPI-----------------PAANVIVVTLQ-MD 123

  Fly   343 SKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQN 407
            ....|:|:|.:....:           .|..|.....:|.|:.   |.|.|:  :|..:  ...|
  Rat   124 IDKLNITLLRIFRQGV-----------AAALGLLPQQVHINRL---IEKKSQ--IELFV--SPGN 170

  Fly   408 LRPYTDYRVIVKAFTTKNEGEPSDQIAQ------RTDVGGPSAP--AIVNLT--------CHSQE 456
            .:|                |||....|:      ..||...|.|  .|::::        .|..:
  Rat   171 RKP----------------GEPQALQAEEVLRSLNVDVLRQSLPQFGIIDVSPEKNVLQGQHEAD 219

  Fly   457 SITIRWRRPYEFYNTIDF--------------YIIKTRL---AGQDTHRDIRINASAKELETAMI 504
            .|   |.:. .||..:.|              |.:|.||   ..||..::..|:.|...|:.|.
  Rat   220 KI---WSKE-GFYAVVIFLSIFIIIVTCLMIIYRLKERLQLSLRQDKEKNQEIHLSPIALQQAQ- 279

  Fly   505 LQNLTTNSYYEVKVAAATFS----------VINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSH 559
                     .|.|.|.:...          |::|:.....:...:....:.|:..:::|:..|..
  Rat   280 ---------SEAKAAHSMVQPDQAPKVLNVVVDPQGQCTPEIRNTASTSVCPSPFRMKPIGLQER 335

  Fly   560 NDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIR 624
            ...|:::.:.:  |..|.:...:|......|   .|..||.........||:
  Rat   336 RGSNVSLTLDM--SSLGNVEPFVAVSTPREK---VAMEYLQSASRVLTRPQL------------- 382

  Fly   625 AAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPC-----EHSQHPENKRKNRYLNITA 684
                    ...|||.|            .:|:|.:  ::|.     :....|.:..||||..|..
  Rat   383 --------RDVVASSH------------LLQSEFM--EIPMNFVDPKEIDIPRHGTKNRYKTILP 425

  Fly   685 YDHSRVHLHPTPGQKKNL-----DYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFWRMIWEQRVA 743
            ...|||.|.|     ||:     .|||||:|.||. |..|||.||||:.:|.:.||:|:|::...
  Rat   426 NPLSRVCLRP-----KNITDPLSTYINANYIRGYSGKEKAFIATQGPMINTVNDFWQMVWQEDSP 485

  Fly   744 IIVMITNLVERGRRKCDMYWP-KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNT 807
            :|||||.|.|: ..||.:||| |.|:  ||.::|.:|.......||:|.|.:       |:..:|
  Rat   486 VIVMITKLKEK-NEKCVLYWPEKRGI--YGKVEVLVIGVNECDNYTIRNLVL-------KRGSHT 540

  Fly   808 EKLVYQYHYTNWPDHGTPDHPLPVLNF---VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAM 869
            :. |..|.||:||||.|||...|:|..   |::...|:... ||:|||||||:||||.:|.....
  Rat   541 QH-VKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASEGR-GPVVVHCSAGIGRTGCFIATSIG 603

  Fly   870 LKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDA--LVEAIASGET 918
            .:|::::.:|:....:..:|..|..:|||.|||.|:|.|  |.|:..|.||
  Rat   604 CQQLKEEGVVDALSIVCQLRVDRGGMVQTSEQYEFVHHALCLFESRLSPET 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	1/7 (14%)
		fn3	249..331	CDD:278470	17/96 (18%)
		FN3	342..437	CDD:238020	17/100 (17%)
		FN3	442..520	CDD:238020	21/104 (20%)
		PTPc	646..911	CDD:214550	104/281 (37%)
		PTPc	676..911	CDD:238006	100/246 (41%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Ptprr	NP_446046.2	PTPc	391..643	CDD:214550	102/270 (38%)
		PTPc	416..643	CDD:238006	98/243 (40%)
		Substrate binding. /evidence=ECO:0000250	587..593		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900