Protein Alignment Ptp99A and PTP3

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_010998.2
• Gene: PTP3 / 856807
• SGDID: S000000877
• Length: 928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1042
• Identity: 211/1042 - (20%)
• Similarity: 367/1042 - (35%)
• Gaps: 354/1042 - (33%)

  Fly   138 DVPD--PPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATS 200
            |.|.  |.:|..::|.||..|..| :| .:.|:||:..:.....          :.||....|:|
Yeast     6 DCPSILPTDRTSVLSETSTLVGSS-SH-VYSRHAPMNSYHNSMN----------SNIYHSPKASS 58

  Fly   201 YQVTGLTPFTVYSFRLLAVNKLGISP--PS---KESYY-------IVTLREAPTGKPI------- 246
                   |...|......:.|...:|  ||   ||..|       ::|..|  .||.|
Yeast    59 -------PLVSYKTSSPVLLKRATAPVLPSFKPKEQRYNKPQGCSLITAVE--LGKIIETLPDEK 114

  Fly   247 -------PTTAHNTS--STSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVE 302
                   |.|.|..|  :.|:::..    |.|:|              |..|.|.. .:.||...
Yeast   115 VLLLDVRPFTEHAKSIITNSIHVCL----PSTLL--------------RRKNFTFS-KLLDNLTP 160

  Fly   303 SHE--------IQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSIT 359
            |.:        |.||:        :.:::......|:::             :|....:::..|.
Yeast   161 SEQSVLKSKLAIDNLR--------IIIYDSTANQTESSV-------------SLPCYGIASKLIE 204

  Fly   360 MSWHPPKNQNGAIAGYHVF------HIHDNQTGVEIVKNSR-NSVETLIHFELQNLRPYTDYRVI 417
            ...:..|..:..:.|:..|      ||:.|....:.:.::. .|.:|.:...|.|..|:
Yeast   205 FDTNVKKTVSILMCGFPQFKILFPDHINTNTFNSDCISSAEPKSPKTNLMNSLHNTAPH------ 263

  Fly   418 VKAFTTKNEGE-------PSDQIAQRTDVGGPSAPAIV----NLTCHSQESITIRWRRP------ 465
            :.|.|..:..:       |.|..:..::.....:|..|    .::..|..|...:::.|
Yeast   264 MTATTPLSSPQMNLKLKVPDDSRSDHSNFSSSPSPRNVLSDSPMSSSSPISALFKFQLPAPQTNI 328

  Fly   466 ---YEFYNTIDFYIIKTRLAG---QDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFS 524
               ::|....:...::|.|:.   ::.|.....|.|||:     .|||...
Yeast   329 NQMFKFSQNEEIMGLETYLSAVNIKEEHERWYNNDSAKK-----SLQNFQF-------------- 374

  Fly   525 VINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSH--NDYNLAVLVGIIFSCFGIIL------II 581
               ||        ....::...|.:||...:|..:  .:|...|:..:|...|..::      ::
Yeast   375 ---PK--------NQNSLEKDTNKDKLGFQIRYENLSKNYEKEVIDSVIPEWFQHLMSIPKIELV 428

  Fly   582 MAF----FLWSRKCFHAA-------YYYLDDPPHHP---NAPQVDWEVPVKIGDEIRA-----AV 627
            ..|    ||..|:..|:.       .:.|:.|..:|   .:......:|.|..|..:.     :.
Yeast   429 SQFQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSSTIMPPKFPDVNKVQKRSHSQ 493

  Fly   628 PV-NEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRV- 690
            |: .:::|:.:.|..:.|           ::..|||:..  |...|...||||.:|..|:||||
Yeast   494 PIFTQYSKYKSMLSLESD-----------SDSESDDVII--SSGVELGAKNRYKDIFPYEHSRVI 545

  Fly   691 ------------HLHPTPGQKKNLDYINANFID----GYQKGHAF------------IGTQGPLP 727
                        |.|.|.......:|||||::.    ..::..:|            |.||.|:|
Yeast   546 LKKGLQSSKGIKHSHSTSDGGILDNYINANYLSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMP 610

  Fly   728 DTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVM---STYTV 789
            .|...|:..|....|.:::.:||..|.|..||..|| ::|  .|..|.|||:|::::   ||.::
Yeast   611 STVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYW-QEG--NYNGIHVKLLEKKILKMPSTTSM 672

  Fly   790 R--TLQIKHLKLKK---------------------------------KKQCNTE----------- 808
            |  |:..::..|..                                 ...|:.:
Yeast   673 RKNTMGTQNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAILIR 737

  Fly   809 KLVYQYH------------YTNWPDHGTPDHPLPVLNFVKKSS-------AAN---PAEAGPIVV 851
            |::..||            ..||||.||..:|:.:|..:...:       |.|   ..:...|:|
Yeast   738 KILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILV 802

  Fly   852 HCSAGVGRTGTYIVLDAMLKQIQ-----QKNIV----------------NVFGFLRHIRAQRNFL 895
            |||||.|||||...:|::|...:     ||..|                |:|      |.||..:
Yeast   803 HCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINIF------RKQRISM 861

  Fly   896 VQTEEQYIFLHDALV--------------EAIASGETNL----MAEQVEELKNCTPYLEQQYKNI 942
            ||...|:||::|.|:              :...|.:.|:    :.||:|:|:....:::.:.|.:
Yeast   862 VQNINQFIFIYDCLLFYFRLRLDDITERTDGDGSNKDNISLSALIEQIEKLEILQTFVDDKLKEL 926

  Fly   943 IQ 944
            .|
Yeast   927 PQ 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	25/109 (23%)
		FN3	243..337	CDD:238020	21/117 (18%)
		fn3	343..430	CDD:394996	15/100 (15%)
		FN3	442..520	CDD:238020	16/93 (17%)
		R5-PTPc-1	704..907	CDD:350397	76/310 (25%)
		R5-PTP-2	989..1182	CDD:350398
PTP3	NP_010998.2	DSP_MapKP	97..231	CDD:238723	28/175 (16%)
		PTP_fungal	571..873	CDD:350509	76/310 (25%)