DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptp99A and Kalrn

DIOPT Version :9

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:XP_038944566.1 Gene:Kalrn / 84009 RGDID:621865 Length:2989 Species:Rattus norvegicus


Alignment Length:474 Identity:96/474 - (20%)
Similarity:161/474 - (33%) Gaps:136/474 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 IIPGFVLLLILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTT 80
            :.|.|::.|:             |||.|        .|..|.:.|.......  .|:.||.....
  Rat  2472 VAPEFLVPLV-------------DVTCL--------LGDTVLLQCKACGRPK--PTITWKGPDQN 2513

  Fly    81 IAQFANRIPLLHSPRIQLLSDNFG---LQFSPSLASDTSEYICL-VNDRHIPEAIVDLLVQDVPD 141
            |....|     .|....:.|.:.|   |:....:..|:..|.|: .||.........:.||.||.
  Rat  2514 ILDTDN-----SSATYTISSCDSGESTLKICNLMPQDSGIYTCIATNDHGTASTSATVKVQGVPA 2573

  Fly   142 PPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVTGL 206
            .|.||:....:..||.|.|.......|..::.:.:|.||....:|:|..   ..|..|...:..|
  Rat  2574 APNRPIAQERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQVWQQSV---ASTLDTYLVIEDL 2635

  Fly   207 TPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWKA--PPPDT 269
            :|...|.||:.|.|..|||.||:.|.::          .:|  .::.::....||||.  ....|
  Rat  2636 SPGCPYQFRVSASNPWGISLPSEPSEFV----------HLP--EYDAAADGATISWKENFDSAYT 2688

  Fly   270 ILGEFLGYRITYRPRDRDPNDTKEIYI-------RDNTVESHE---IQNLQTYTQYKVTVQVFNP 324
            .|.|....|.:...:.......|::.:       :.....:||   :|:|| :.||......:. 
  Rat  2689 ELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQ-HPQYVTLHDTYE- 2751

  Fly   325 EGLGPETTILV--MTDEG--------------------------------------VPSKPQNLT 349
               .|.:.||:  :.|:|                                      :..||:||.
  Rat  2752 ---SPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLL 2813

  Fly   350 I-----------LDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQ--TGVEIVKNSRNSVET-- 399
            |           :|:. :::.:|.|           :|:.|:..|.  ...|:::....|:.|  
  Rat  2814 IDLRIPVPRVKLIDLE-DAVQISGH-----------FHIHHLLGNPEFAAPEVIQGIPVSLGTDI 2866

  Fly   400 -----LIHFELQNLRPYTD 413
                 |.:..|..:.|:.|
  Rat  2867 WSIGVLTYVMLSGVSPFLD 2885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020 29/95 (31%)
fn3 249..331 CDD:278470 17/93 (18%)
FN3 342..437 CDD:238020 18/92 (20%)
FN3 442..520 CDD:238020
PTPc 646..911 CDD:214550
PTPc 676..911 CDD:238006
PTPc 935..1186 CDD:214550
PTPc 963..1169 CDD:238006
KalrnXP_038944566.1 SEC14 42..180 CDD:214706
SPEC 193..413 CDD:238103
SPEC 314..539 CDD:238103
SPEC 540..769 CDD:238103
SPEC 894..1132 CDD:238103
SPEC 1138..1238 CDD:197544
RhoGEF 1287..1457 CDD:238091
PH1_Kalirin_Trio_like 1464..1586 CDD:270060
SH3_Kalirin_1 1652..1711 CDD:212786
SH3-RhoG_link 1708..1892 CDD:406906
RhoGEF 1935..2104 CDD:395496
PH2_Kalirin_Trio_p63RhoGEF 2109..2243 CDD:270061
SH3_Kalirin_2 2327..2385 CDD:212787
Ig strand A 2466..2469 CDD:409353
I-set 2474..2568 CDD:400151 24/121 (20%)
Ig strand A' 2482..2485 CDD:409353 2/2 (100%)
Ig strand B 2491..2498 CDD:409353 2/6 (33%)
Ig strand C 2504..2512 CDD:409353 3/7 (43%)
Ig strand C' 2515..2517 CDD:409353 0/1 (0%)
Ig strand D 2523..2532 CDD:409353 1/8 (13%)
Ig strand E 2534..2538 CDD:409353 1/3 (33%)
Ig strand F 2547..2555 CDD:409353 2/7 (29%)
Ig strand G 2558..2568 CDD:409353 0/9 (0%)
FN3 2572..2663 CDD:238020 29/93 (31%)
STKc_Kalirin_C 2693..2940 CDD:271017 32/210 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.