Protein Alignment Ptp99A and ptpru

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_012812827.1
• Gene: ptpru / 733850
• XenbaseID: XB-GENE-922688
• Length: 1439
• Species: Xenopus tropicalis
• Alignment Length: 1373
• Identity: 347/1373 - (25%)
• Similarity: 566/1373 - (41%)
• Gaps: 320/1373 - (23%)

  Fly    19 GFVLL--LILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDT--LVWKTAST 79
            |::.|  ::|.:.|.|:|...   :.|..|:||  ||:|.|..||.....:..::  |..:....
 Frog   168 GYIGLDDILLFSYPCTRAPHF---SRLGEVEVN--AGQNATFQCPASGRANDGESFLLQRQNGGI 227

  Fly    80 TIAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYI-CLVNDRHIPEAIVDLLVQDVPDPP 143
            |.|....|:    |....|:|  |.||.:.....|....: |.::...:.. ..:|:|::.|.|.
 Frog   228 TSAGVIQRV----SHHRFLVS--FQLQDAGPSEQDLYRCVSCSIHGAGVSN-FAELVVKEPPTPI 285

  Fly   144 ERP---------LLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNAT 199
            ..|         |::...:||:         ..:.|:....||.|..... |::...:    .|.
 Frog   286 APPQLLRAGPTYLIVQLNTRSI---------IGDGPIVRREIEYRVSGSS-WKERHAV----TAH 336

  Fly   200 SYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNT-------SSTS 257
            :|::..|.|.:.|...:|      ::.|.          |..||||.|.....|       :...
 Frog   337 TYKLWHLDPDSQYHISVL------LTRPG----------EGGTGKPGPALISRTKCAEPMRAPKG 385

  Fly   258 VYISWKAPPPDTILGEFLGYRIT----------YRPRDRDPNDTKEIYIRDNTVESHEIQNLQTY 312
            :..|.:.|...|:..|.:|:.||          |.   .:.:..::....:.....:.:..|..|
 Frog   386 LSCSAEQPRQLTLQWEAVGFNITRCHTFSVMLCYH---TELSSIQDCVTAEGGSSQYTLHGLAPY 447

  Fly   313 TQYKVTVQVFNPEGLGPETTILVMTDEGVP-SKPQNLTILDVSANSITMSWHPPKNQNGAIAGYH 376
            ......:.:.||||......:...|.|.|| |......||....:::.:.|..|...||.:..|.
 Frog   448 RAVHCHLIITNPEGRKEGKEVTCHTQEDVPGSIASESLILVPQEDAVLLMWDKPVEPNGVLTQYE 512

  Fly   377 VFHIHDNQTGVEIVKNSRNSV--------------ETLIHFELQNLRPYTDYRVIVKAFTTKNEG 427
            :        |.:|:::|..||              || .|. |.||.|.|.|.:.|:|..:|..|
 Frog   513 I--------GYQIIESSDPSVSVPGIRGTVCKLPNET-SHL-LTNLLPGTTYLLSVRARNSKGYG 567

  Fly   428 EPSDQIAQRTDVGGPS-----APAIVNLTCHSQESITIRWR------RPYEFYNTIDFYIIKTRL 481
             ||......|::..|:     .|..::.|   .::||:..|      .|..||..:        :
 Frog   568 -PSVLTELTTNISAPTFDYSDLPPPLDET---DKTITVLLRPAQGRGSPVSFYQVL--------V 620

  Fly   482 AGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSV--------------------- 525
            .|:.:.|      |.:||..........  ||.|.::..::..|
 Frog   621 EGETSPR------SRRELGVPGCFPGAA--SYEEAEIEGSSSYVGAEIPPTDLPRDTPFIVGDNR 677

  Fly   526 ---------INPKK---IVLGKFS----ESRI----IQLQPNCEKLQPLLRQSHNDYNLAVLVGI 570
                     ::|::   |.|...|    |:|:    |..:..|:..|...........:.:::||
 Frog   678 SYGGYWNPPLDPRRGYLIYLQAASHHRGETRLNCVRIARKAPCKDSQRSSMAPQRSDEMGLVLGI 742

  Fly   571 IFSCFG----IILIIMAFFLWSRK---CFHAAYYYLDD-------PPHHPN----APQVDWEVP- 616
               |.|    .|:::.|..|..||   .|..|||....       |..|.|    ||:...::.
 Frog   743 ---CAGGLVVFIILLGAVILIVRKGRTQFSYAYYPKPIGLTKSALPSRHENSNCAAPREHTKMTD 804

  Fly   617 ------------------VKIGD-------------------------------EIRAAVPVNEF 632
                              .::|:                               ::..||.|.:.
 Frog   805 QPTLLQEEAALAFLHSYNTRVGEPRVGSVTESSSLLGGSPRRGGGRKGSPYHTGQLHPAVRVADL 869

  Fly   633 AKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPG 697
            .:|:..:......||.:|||:..:..:|         ..::|.|.|......|:..||.|||...
 Frog   870 LQHINQMKVAEGYGFKQEYESFFDWDVS---------KKKDKGKGRQDIPPNYERHRVRLHPLQA 925

  Fly   698 QKKNLDYINANFID------GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGR 756
            :..: :.||||:||      ||.:.:.||.||||..|....||||:|::.|:.|||||.|||.||
 Frog   926 ECSS-EEINANYIDIRINREGYHRSNHFIATQGPKQDMIYDFWRMVWQEHVSSIVMITKLVEVGR 989

  Fly   757 RKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPD 821
            .||..||| |..:|||.|:|.|:..|.::.|:||||.:      :::.......|.|:|:.:|||
 Frog   990 VKCSKYWP-DTSDTYGDIRVTLLNTETLAEYSVRTLTL------ERRGYTVRHEVKQFHFLSWPD 1047

  Fly   822 HGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLR 886
            ||.|.|...:|.|:::..::.|.:|||:|||||||.||||.|||||.||...:.:.:|:::..::
 Frog  1048 HGVPYHATGLLAFIRRVKSSTPPDAGPVVVHCSAGAGRTGCYIVLDVMLDMAECEGVVDIYNCVK 1112

  Fly   887 HIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQF--QPKD 949
            .:.::|..:|||:|||:|:|||::||...|:|.:.|        |.  ..|.||.::|.  |...
 Frog  1113 TLCSRRINMVQTQEQYVFIHDAILEACLCGDTAIPA--------CD--FRQTYKEMLQIDTQSNS 1167

  Fly   950 IHIASAMKQVNSI-------------------KNRGA-IFPIEGSRVHLTPKPGEDGSDYINASW 994
            .|:....:.:||:                   |||.. :.|.:.:...|....|||.|:||||..
 Frog  1168 THLRDEFQTLNSVTAQLGVEECSIALLPHNRDKNRSMDVLPPDRALPLLLSAHGEDTSNYINAVL 1232

  Fly   995 LHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFA----QFWPDEAT----P 1051
            ...:.|..:.|:|.||:.:||.|||::|:|:...|||:|:.|:..|.|    |:|||...    |
 Frog  1233 TDSYTRSSNVIITVHPLQNTITDFWRLVYDYGCSTVVMLNQLNQSNSAWPCLQYWPDSGICRYGP 1297

  Fly  1052 IESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSW-PEMSNPNSIYDF-----IV 1110
            :|     |:|::.:.:.|.|:|.|.:|:|..|..|.||......| |....|:|...|     :|
 Frog  1298 ME-----VQFVSGSVEEDVVTRVFRVQNIARDEHLMVKHFQYLRWSPYRETPDSKRSFLQLLSLV 1357

  Fly  1111 DVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSE 1175
            :..:..|  |....::....||.::.||||.:.:...:......:|:...|...|.:|.:..:.:
 Frog  1358 EQWQEQN--REHRTLVHCLNGGGRSGTFCACAMIHDMIRCHCVMDVFYAVKTLRNIKPNMVETLD 1420

  Fly  1176 DIRVIYNI 1183
            ..|..|.|
 Frog  1421 QYRFCYEI 1428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	18/104 (17%)
		FN3	243..337	CDD:238020	19/110 (17%)
		fn3	343..430	CDD:394996	26/100 (26%)
		FN3	442..520	CDD:238020	17/88 (19%)
		R5-PTPc-1	704..907	CDD:350397	92/208 (44%)
		R5-PTP-2	989..1182	CDD:350398	60/206 (29%)
ptpru	XP_012812827.1	MAM	27..182	CDD:459878	3/13 (23%)
		IG_like	192..278	CDD:214653	22/94 (23%)
		fn3	287..361	CDD:394996	16/103 (16%)
		FN3	<343..>624	CDD:442628	69/321 (21%)
		fn3	490..568	CDD:394996	23/88 (26%)
		PTP_DSP_cys	931..1141	CDD:475123	97/216 (45%)
		PTP_DSP_cys	1227..1431	CDD:475123	62/209 (30%)