Protein Alignment Ptp99A and Ptprv

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_149090.1
• Gene: Ptprv / 64576
• RGDID: 621123
• Length: 1711
• Species: Rattus norvegicus
• Alignment Length: 1197
• Identity: 286/1197 - (23%)
• Similarity: 470/1197 - (39%)
• Gaps: 310/1197 - (25%)

  Fly   142 PPERPLLISFTS---RSVNLSWAHSQHPRNA-PVTHFIIETREGEDGIWEQLARIYT-----KTN 197
            ||..|.|::.||   ..:.:||||....|:. .||            ::::..|..|     |.:
  Rat   655 PPSAPTLVNVTSDAPTQLQVSWAHVPGGRSRYQVT------------LYQESTRTATSIMGPKED 707

  Fly   198 ATSYQVTGLTPFTVYSFRLL---------AVNKLGISPPSKESYYIVTLREA--------PTGKP 245
            .||:  .||||.|.|...::         |.|....:.|...:..:|:::..        |:|..
  Rat   708 GTSF--LGLTPGTKYKVEVISWAGPLYTAAANVSAWTYPLIPNELLVSMQAGSAVVNLAWPSGPL 770

  Fly   246 IPTTAHNTSSTSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQNLQ 310
            .....|...|.:.::||:.|   ..||:.|     :..||..|..|..:.:|...
  Rat   771 GQGACHAQLSDAGHLSWEQP---LKLGQEL-----FMLRDLTPGHTISMSVRCRA---------- 817

  Fly   311 TYTQYKVTVQVFNPEGLGP---ETTILVMTDEGVPSKPQNLTILDV----SANSITMSWHPPKNQ 368
                             ||   .|.::|::.|..|       :.||    .|..:.::|..|...
  Rat   818 -----------------GPLQASTHLVVLSVEPGP-------VEDVLCHPEATYLALNWTMPAGD 858

  Fly   369 NGAI----------AGYH-VFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIV---- 418
            ....          .|.| ||.:  |.:|..::              |.||.|.|.||:.:
  Rat   859 VDVCLVVVERLVPGGGTHFVFQV--NTSGDALL--------------LPNLMPTTSYRLSLTVLG 907

  Fly   419 -----------------KAFTTKNEGEPSDQIAQRTDVG------------------GPSAPAIV 448
                             :|:......|| .|:...|.:|                  |..|...:
  Rat   908 RNSRWSRAVSLVCSTSAEAWHPPELAEP-PQVELGTGMGVTVMRGMFGKDDGQIQWYGIIATINM 971

  Fly   449 NLTCHSQESITIRWRRPYE-FYNTIDFYI--------IKTRLAGQDTHRDIRINASAKELETAMI 504
            .|...|:|:|...|   |: :|...:.::        .....||.   |...:....::.:....
  Rat   972 TLAQPSREAINYTW---YDHYYRGCESFLALLFPNPFYPEPWAGP---RSWTVPVGTEDCDNTQE 1030

  Fly   505 LQNLTTNSYYEVKVAAATFSVINPKKIVL--GKFSESRI---IQLQPNCEKLQPLLRQSHNDYNL 564
            :.|....|.::.:.:...||.:|..:.:|  ..|||.|.   :.:.|                 |
  Rat  1031 ICNGRLKSGFQYRFSVVAFSRLNTPETILAFSAFSEPRASISLAIIP-----------------L 1078

  Fly   565 AVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNA------PQVDWEVPVKIGDEI 623
            .|::|.:.....|:..::....|  :|       |..|....:.      |...|..
  Rat  1079 TVMLGAVVGSIVIVCAVLCLLRW--RC-------LKGPRSEKDGFSKELMPYNLWRT-------- 1126

  Fly   624 RAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHS 688
            ...:|::.|.:...:..|.....|.:|:|.::.  :..|.|...::||:|..||||.::..||||
  Rat  1127 HRPIPIHSFRQSYEAKSAHAHQTFFQEFEELKE--VGKDQPRLEAEHPDNIIKNRYPHVLPYDHS 1189

  Fly   689 RVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVE 753
            ||.|...||:..: ||||||||.||......|.|||||..|.:.|||::|||:|.:|:|:|..:|
  Rat  1190 RVRLTQLPGEPHS-DYINANFIPGYSHTQEIIATQGPLKKTLEDFWRLVWEQQVHVIIMLTVGME 1253

  Fly   754 RGRRKCDMYWPKDGVE-TYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYT 817
            .||..|:.|||.:... |:|.|.:.|:.||....:|.|..|::|...:|:::      |.|..:|
  Rat  1254 NGRVLCEHYWPANSTPVTHGHITIHLLAEEPEDEWTRREFQLQHGTEQKQRR------VKQLQFT 1312

  Fly   818 NWPDHGTPDHPLPVLNFVK--KSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVN 880
            .||||..|:.|..:|.||:  :.........|||:||||||||||||::.|..:|:|::::.:.:
  Rat  1313 TWPDHSVPEAPSSLLAFVELVQEQVQATQGKGPILVHCSAGVGRTGTFVALLRLLRQLEEEKVAD 1377

  Fly   881 VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA--------SGETNLM--AEQ-VEELKNCTPY 934
            ||..:..:|..|..::||..||||||..|:..|.        ||..::|  |:. .:...|....
  Rat  1378 VFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGPPDSSDSGPISVMDFAQACAKRAANANAG 1442

  Fly   935 LEQQYKNIIQ---------FQPKDIHIASAMKQVNSIKN-------------RGAIFPIEGSRVH 977
            ..::||.:.|         ..|.|.:..|.:.:.:|.:.             ..::||
  Rat  1443 FLKEYKLLKQAIKDGTGSLLPPPDYNQNSIVSRRHSQEQFALVEECPEDSMLEASLFP------- 1500

  Fly   978 LTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLD----- 1037
                .|..|.|::..:...|            |     |:.|:|||:|:|..:|.|...|
  Rat  1501 ----GGPSGCDHVVLTGSAG------------P-----KELWEMVWEHDAHVLVSLGLPDTKEKP 1544

  Fly  1038 -DINFAQFWPDEATPIESDHYRVKFLNKTN-KSDYVSRDFVIQSIQDDYELTVKMLHCP---SWP 1097
             ||     ||.|..||.:|...|..::::| .:.:.|..|.:...:...|..|:.|..|   |..
  Rat  1545 PDI-----WPVEMQPIVTDMVTVHRVSESNTTTGWPSTLFRVIHGESGKERQVQCLQFPCSESGC 1604

  Fly  1098 EMSNPNSIYDFIVDVHERC---NDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQY 1159
            |:. .|::..|:..|.:.|   ...:.|.::........|..||.|:..|..:.....|.:|:..
  Rat  1605 ELP-ANTLLTFLDAVGQCCFRGKSKKPGTLLSHSSKNTNQLGTFLAMEQLLQQAGTERTVDVFNV 1668

  Fly  1160 AKLYHNKRPGVWTSS-EDIRVIYNILS 1185
            | |..::..|:.|.: |....:||.|:
  Rat  1669 A-LKQSQACGLMTPTLEQYIYLYNCLN 1694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	27/111 (24%)
		FN3	243..337	CDD:238020	18/96 (19%)
		fn3	343..430	CDD:394996	20/122 (16%)
		FN3	442..520	CDD:238020	13/86 (15%)
		R5-PTPc-1	704..907	CDD:350397	85/205 (41%)
		R5-PTP-2	989..1182	CDD:350398	47/206 (23%)
Ptprv	NP_149090.1	FN3	49..110	CDD:214495
		fn3	<148..201	CDD:394996
		FN3	377..>749	CDD:442628	27/107 (25%)
		PTP_tm	950..1069	CDD:465889	21/124 (17%)
		PTP_DSP_cys	1178..1407	CDD:475123	99/235 (42%)
		PTP_DSP_cys	1477..1693	CDD:475123	55/250 (22%)