DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and PTPRZ1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_002842.2	Gene:	PTPRZ1 / 5803	HGNCID:	9685	Length:	2315	Species:	Homo sapiens

Alignment Length:	1382	Identity:	418/1382 - (30%)
Similarity:	653/1382 - (47%)	Gaps:	289/1382 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YGNHRGLIIPGFVLLLILATLPATQAGRIFDVTNLDYVKVNAEAGK-NVTIPC-----PG----- 62
            |||...|.||.|..::..:  .:|....::|..|    |:||...: :|:|..     ||
Human  1048 YGNETELQIPSFNEMVYPS--ESTVMPNMYDNVN----KLNASLQETSVSISSTKGMFPGSLAHT 1106

  Fly    63 ---VNEHSL------------VDTLVWKTASTTIAQF--ANRIPLLHSP-RIQLLSDNFGLQFSP 109
               |.:|.:            ..|:...:..|::...  ||..|....| ..::||.:..|.|..
Human  1107 TTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYE 1171

  Fly   110 SLASDTSEYICLVNDRHIPEAIVDLLVQDV-PDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTH 173
            :.||.::|.:.   ......:.||.|::.| |..|..|:|:. |.:...:|         :.:.|
Human  1172 TSASFSTEVLL---QPSFQASDVDTLLKTVLPAVPSDPILVE-TPKVDKIS---------STMLH 1223

  Fly   174 FIIETREGEDGIWEQLARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLR 238
            .|:......:.:          .::||..|..::|.:  .....::..|.||..| |.|..|.|:
Human  1224 LIVSNSASSENM----------LHSTSVPVFDVSPTS--HMHSASLQGLTISYAS-EKYEPVLLK 1275

  Fly   239 EAPTGKPIPTTAHNT---SSTSVYISWKAPPPDTILGEFLGYRITYRP--RDRDPNDTKEIYIRD 298
            ...:.:.:|:...|.   .:.::.|:...||.        |..:...|  ...:|.:|    :.:
Human  1276 SESSHQVVPSLYSNDELFQTANLEINQAHPPK--------GRHVFATPVLSIDEPLNT----LIN 1328

  Fly   299 NTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETT---ILVMTDEGVPSKPQNLTILDVSAN---S 357
            ..:.|.||   .|.|:..||.:||    .|..|.   ..|.||..||....::.|..||.:   |
Human  1329 KLIHSDEI---LTSTKSSVTGKVF----AGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGS 1386

  Fly   358 ITMS------------WHPPKNQNGAIAGYHVFHIHDN---------QTGVEIVK-----NSRNS 396
            :|.:            .|..|:..|.:.|.......|:         ..|:.|.|     :.|.|
Human  1387 VTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRES 1451

  Fly   397 VETLIH---------FELQNLRPYT-------DYRVIVKAFTTK--------------------N 425
            .|.:::         .:..|...|:       |.||...:..::                    |
Human  1452 QEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHN 1516

  Fly   426 EGEPSDQIAQRTDVG------GPSAPAIVNLTCHSQ--------ESITIRWRRPYEFYNTIDFYI 476
            :|:..:.|    ..|      .|.:.|...||...:        :|:.       |...:.||..
Human  1517 DGKEENDI----QTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN-------ENETSTDFSF 1570

  Fly   477 IKTR-------LAGQDTH------RDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINP 528
            ..|.       ||..|:.      :....:.:::..|...:.:...:||.:|.::..|. .:.:.
Human  1571 ADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAE-GLESE 1634

  Fly   529 KKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFH 593
            ||.|:                   ||:          ::..:.|.|   :::::...::.||||.
Human  1635 KKAVI-------------------PLV----------IVSALTFIC---LVVLVGILIYWRKCFQ 1667

  Fly   594 AAYYYLDDPPHHPNAPQVDWEVPV---KIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQ 655
            .|::||:|    ..:|:|....|.   .|.|:: .|:|:..|.||||.|||..  ||:.|:|.::
Human  1668 TAHFYLED----STSPRVISTPPTPIFPISDDV-GAIPIKHFPKHVADLHASS--GFTEEFETLK 1725

  Fly   656 ------NECISD-DLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNL-DYINANFIDG 712
                  ..|..| .:..:.|.||:||.||||:||.|||||||.|.....:...| ||||||::||
Human  1726 EFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDG 1790

  Fly   713 YQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVK 777
            |.:..|:|..||||..|.:.|||||||..|.:|||||||||:||||||.|||.||.|.||...|.
Human  1791 YNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVT 1855

  Fly   778 LIEEEVMSTYTVRTLQIKHLKLKKKKQCN--TEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSA 840
            ....:|::.||||...:::.|:||..|..  :.::|.|||||.|||.|.|::.||||.||:|::.
Human  1856 QKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY 1920

  Fly   841 ANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFL 905
            |.....||:||||||||||||||||||:||:|||.:..||:||||:|||:|||:||||||||:|:
Human  1921 AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFI 1985

  Fly   906 HDALVEAIASGETNLMAEQVEELKNC--------TPYLEQQYKNIIQFQPKDIHIASAMKQVNSI 962
            ||.|||||.|.||.::...:....|.        ...||:|::.:.|...:....::|:||.|..
Human  1986 HDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNRE 2050

  Fly   963 KNR-GAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHN 1026
            ||| .:|.|:|.|||.::...|| |:||||||::.|:.:..:||:||||:.|||||||:|:||||
Human  2051 KNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHN 2114

  Fly  1027 AQTVVLLSSLDDINFAQ----FWPDEATPIESDHYRVKFLNK-----TNKSDYVSRDFVIQSIQD 1082
            ||.||::.  |..|.|:    :||::..||..:.::|..:.:     :|:...:.:||::::.||
Human  2115 AQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177

  Fly  1083 DYELTVKMLHCPSWPEMSNP-NSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAI 1146
            ||.|.|:...||.||...:| :..::.|..:.|...: |:||:::.|.:||..|.||||:::|..
Human  2178 DYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMH 2241

  Fly  1147 EMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTT--- 1208
            ::|..::.:|||.||:.:..||||:...|..:.:|.:         :|...:.|.|....|:
Human  2242 QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV---------ILSLVSTRQEENPSTSLDS 2297

  Fly  1209 ---ATPDLYSKICSNVA 1222
               |.||      .|:|
Human  2298 NGAALPD------GNIA 2308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	18/95 (19%)
		fn3	249..331	CDD:278470	18/86 (21%)
		FN3	342..437	CDD:238020	25/159 (16%)
		FN3	442..520	CDD:238020	16/98 (16%)
		PTPc	646..911	CDD:214550	151/274 (55%)
		PTPc	676..911	CDD:238006	140/237 (59%)
		PTPc	935..1186	CDD:214550	97/261 (37%)
		PTPc	963..1169	CDD:238006	84/216 (39%)
PTPRZ1	NP_002842.2	PARM	1089..>1255	CDD:293666	35/190 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1123..1160		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1397..1523		18/125 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1572		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1584..1621		4/36 (11%)
		PTPc	1716..1991	CDD:214550	151/274 (55%)
		PTPc	1752..1991	CDD:238006	140/238 (59%)
		Substrate binding. /evidence=ECO:0000250	1933..1939		5/5 (100%)
		PTPc	2022..2280	CDD:214550	97/270 (36%)
		PTPc	2050..2280	CDD:238006	89/242 (37%)
		alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..507
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..650
		MFMR	684..>763	CDD:285072
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1231
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1056
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41334
orthoMCL	1	0.900	-	-		OOG6_102521
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870