| Sequence 1: | NP_651691.4 | Gene: | Ptp99A / 43469 | FlyBaseID: | FBgn0004369 | Length: | 1397 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002841.3 | Gene: | PTPRS / 5802 | HGNCID: | 9681 | Length: | 1948 | Species: | Homo sapiens |
| Alignment Length: | 1518 | Identity: | 399/1518 - (26%) |
|---|---|---|---|
| Similarity: | 626/1518 - (41%) | Gaps: | 450/1518 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 59 PCPGVNEHSLVDTLVWKTASTTIAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVN 123
Fly 124 DRHIPEAIVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQ 188
Fly 189 LARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGI---SPPSKESYYIVTLREAPTGKPIPTTA 250
Fly 251 HNTSSTSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQNLQTYTQY 315
Fly 316 KVTVQVFNPEGLGPETT-ILVMTDEGVPS-KPQNLTILDVSANSITMSWHPPK--NQNGAIAGYH 376
Fly 377 VFHIHDNQTGVE----------IVKNSRNSVETLIHFE--LQNLRPYTDYRVIVKAFTTKNEG-- 427
Fly 428 --------------------------------EP-----SDQI---------------------- 433
Fly 434 --------------------AQRTDVG-GPSAPAIVNL-----TCHSQ----------ESITIRW 462
Fly 463 RRPY--EFYNTIDFYIIKTRLAGQ-DTHRDIRINASAKE-LETAMILQNLTTNSYYEVKVAAAT- 522
Fly 523 -----FS-----------VINPK----KIVL--------------------------------GK 535
Fly 536 FSESRIIQLQPNC---------------------------------------------------- 548
Fly 549 ----------------------EKLQPL----------------------LRQS----------- 558
Fly 559 --------------HNDYN-----------------LAVL------------------------- 567
Fly 568 -----------VGIIFSCFGIILIIMAFFLWSR-------------KCFHAAYYYLDDPPHHPNA 608
Fly 609 P----QVDWEVPVK-IGDEIR------------AAVPVNEFAKHVASLHADGDIGFSREYEAIQN 656
Fly 657 ECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIG 721
Fly 722 TQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMST 786
Fly 787 YTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVV 851
Fly 852 HCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG 916
Fly 917 ETNLMAE----------QVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGA-IFP 970
Fly 971 IEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSS 1035
Fly 1036 LDDI---NFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWP 1097
Fly 1098 EMSNPNS---IYDFIVDVHERCNDY-RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQ 1158
Fly 1159 YAKLYHNKRPGVWTSSEDIRVIY 1181 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ptp99A | NP_651691.4 | FN3 | 140..236 | CDD:238020 | 28/98 (29%) |
| fn3 | 249..331 | CDD:278470 | 25/81 (31%) | ||
| FN3 | 342..437 | CDD:238020 | 31/190 (16%) | ||
| FN3 | 442..520 | CDD:238020 | 22/96 (23%) | ||
| PTPc | 646..911 | CDD:214550 | 135/264 (51%) | ||
| PTPc | 676..911 | CDD:238006 | 125/234 (53%) | ||
| PTPc | 935..1186 | CDD:214550 | 77/255 (30%) | ||
| PTPc | 963..1169 | CDD:238006 | 70/213 (33%) | ||
| PTPRS | NP_002841.3 | Ig | 32..120 | CDD:299845 | |
| I-set | 33..124 | CDD:254352 | |||
| Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 | 68..72 | ||||
| IG_like | 141..234 | CDD:214653 | |||
| Ig2_RPTP_IIa_LAR_like | 152..235 | CDD:143215 | |||
| IG_like | 251..328 | CDD:214653 | |||
| Ig3_RPTP_IIa_LAR_like | 259..327 | CDD:143216 | |||
| FN3 | 332..421 | CDD:238020 | |||
| FN3 | 428..520 | CDD:238020 | 14/75 (19%) | ||
| FN3 | 525..613 | CDD:238020 | 28/98 (29%) | ||
| FN3 | 621..715 | CDD:238020 | 28/93 (30%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 700..724 | 11/23 (48%) | |||
| FN3 | 723..828 | CDD:238020 | 24/106 (23%) | ||
| FN3 | 838..920 | CDD:238020 | 9/81 (11%) | ||
| FN3 | 932..1029 | CDD:238020 | 24/96 (25%) | ||
| FN3 | 1037..>1097 | CDD:238020 | 7/59 (12%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1311..1340 | 8/31 (26%) | |||
| PTPc | 1392..1647 | CDD:214550 | 135/264 (51%) | ||
| PTPc | 1418..1647 | CDD:238006 | 125/235 (53%) | ||
| Substrate binding. /evidence=ECO:0000250 | 1589..1595 | 5/5 (100%) | |||
| PTPc | 1679..1938 | CDD:214550 | 77/257 (30%) | ||
| PTPc | 1708..1938 | CDD:238006 | 72/227 (32%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0001053 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.910 | |||||