Protein Alignment Ptp99A and PTPRR

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 185/759 - (24%)
• Similarity: 307/759 - (40%)
• Gaps: 194/759 - (25%)

  Fly   233 YIVTLREAPTGKPIPTTAHNTS-STSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYI 296
            :.:.:.:..:|||:....|:.. ..|:.|:     |..|      ||.:|
Human    28 HFLAINQKKSGKPVFIYKHSQDIEKSLDIA-----PQKI------YRHSY--------------- 66

  Fly   297 RDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMS 361
                   |.....|...::::....|......|...:|.|  :|...:.:||.|  .:||.|.::
Human    67 -------HSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAM--DGQDLEVENLPI--PAANVIVVT 120

  Fly   362 WHPPKN----------QNGAIAGYHVF--HIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDY 414
            .....|          :.|..|...:.  .:|.|:     :...:||:|..:       .|
Human   121 LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINR-----LIGKKNSIELFV-------SP---- 169

  Fly   415 RVIVKAFTTKNEGEPSDQIAQRTDVG--------------GPSAPAIVNLTCHSQESITIRWRRP 465
               :...|..::..||:::.:..::.              .|....:...  |..:.|   |.:.
Human   170 ---INRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQ--HEADKI---WSKE 226

  Fly   466 YEFYNTIDF--------------YIIKTRL---AGQDTHRDIRINASAKELETAMILQNLTTNSY 513
             .||..:.|              |.:|.|.   ..||..::..|:.|...|:.| :.:..|.:|.
Human   227 -GFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPA-LSEAKTVHSM 289

  Fly   514 YEVKVAAATFS-VINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGI 577
            .:.:.|....: |::|:.....:...:....:.|:..|::|:..|.....|:::.:.:  |..|.
Human   290 VQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDM--SSLGN 352

  Fly   578 ILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVP-VKIGDE-IRAAVPV---NEFAKHVA 637
            |                             .|.|....| .|:..| :::|..:   ::....||
Human   353 I-----------------------------EPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVA 388

  Fly   638 SLHADGDIGFSREYEAIQNECISDDLPC-----EHSQHPENKRKNRYLNITAYDHSRVHLHPTPG 697
            |.|            .:|:|.:  ::|.     :....|.:..||||..|.....|||.|.|
Human   389 SSH------------LLQSEFM--EIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRP--- 436

  Fly   698 QKKNL-----DYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGR 756
              ||:     .|||||:|.||. |..|||.||||:.:|.|.||:|:|::...:|||||.|.|: .
Human   437 --KNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-N 498

  Fly   757 RKCDMYWP-KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWP 820
            .||.:||| |.|:  ||.::|.:|.......||:|.|.:        ||.:..:.|..|.||:||
Human   499 EKCVLYWPEKRGI--YGKVEVLVISVNECDNYTIRNLVL--------KQGSHTQHVKHYWYTSWP 553

  Fly   821 DHGTPDHPLPVLNF---VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVF 882
            ||.|||...|:|..   |::...|:... ||:|||||||:||||.:|......:|::::.:|:..
Human   554 DHKTPDSAQPLLQLMLDVEEDRLASQGR-GPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDAL 617

  Fly   883 GFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVE 926
            ..:..:|..|..:|||.|||.|:|.||    ...|:.|.||.|:
Human   618 SIVCQLRMDRGGMVQTSEQYEFVHHAL----CLYESRLSAETVQ 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	0/2 (0%)
		FN3	243..337	CDD:238020	16/94 (17%)
		fn3	343..430	CDD:394996	16/98 (16%)
		FN3	442..520	CDD:238020	18/94 (19%)
		R5-PTPc-1	704..907	CDD:350397	86/207 (42%)
		R5-PTP-2	989..1182	CDD:350398
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	98/241 (41%)