Protein Alignment Ptp99A and PTPRG

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_016862450.1
• Gene: PTPRG / 5793
• HGNCID: 9671
• Length: 1485
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 102/550 - (18%)
• Similarity: 168/550 - (30%)
• Gaps: 229/550 - (41%)

  Fly    41 HVFVKMKH--KLERSGCKVTVEDIRIRINNLSAKY------------------RKESM------- 78
            |.|..:.|  ...|:|.||.||.:   ::.|..||                  |||:.
Human   560 HAFQTLTHIYNKVRTGEKVKVEHV---VSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTG 621

  Fly    79 -----LTLSGGSPSRWPLFSK------------IHNILSNDA--------GGLDETAETQEESME 118
                 :.|..|.|     |.:            :|.||....        |.|....:..|..|.
Human   622 VGPLPVVLFNGMP-----FEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMN 681

  Fly   119 EP---PESKTKVYQLKCNYRHENID-----NFFTDLYFNPRYADVTLVTCHDGETFAIPAHRMVL 175
            :|   |...:::...:.:|    :|     |||.|     .||..|::. ..|:|.|:
Human   682 QPNVVPRINSRILTAERDY----LDLTASNNFFVD-----DYARFTILD-SQGKTAAV------- 729

  Fly   176 GNFSMYFANIFDKLNVPQNSNTYIVLPGSISHQTMQILMQYMYTGQSSVPEYNVDDVLRSGELLK 240
                             .||..|:...|..|.:        :|           ||     ..::
Human   730 -----------------ANSMNYLTKKGMSSKE--------IY-----------DD-----SFIR 753

  Fly   241 IRGFW----SESRSGGQ--------QQGSGLAGNKRRMPGAEPPRKMHYR------------QPG 281
            ...||    .:|.||.|        |:.|   .|.|......|.:::.|.            |..
Human   754 PVTFWIVGDFDSPSGRQLLYDAIKHQKSS---NNVRISMINNPAKEISYENTQISRAIWAALQTQ 815

  Fly   282 TSSQDSN------DQGRAPVLPGRSSL-------------KSVDQQSEVASDSGTSAMDSLDEQK 327
            ||:...|      .:|.|..|...:.:             |.|.:.|:         ||.:
Human   816 TSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSK---------MDFI---- 867

  Fly   328 RLAIAAIQRDLHASSMRAMAHGAAALFSSGSLSDVKQEPTEWDDLDDDNDSDEDVMILPEEVVKS 392
             |:.|...||     :..:..|..|:.|:|.:..    |.|    |.:..:.:|..:|...::|:
Human   868 -LSHAVYCRD-----VLKLKKGQRAVISNGRIIG----PLE----DSELFNQDDFHLLENIILKT 918

  Fly   393 KPAADGKPKQSPQTSQAVPDHYSLQQQQQQQSLPQPQPQQLPPQLLAGQVPIDNDLQQQQVQQVQ 457
                         :.|.:..|  :||.:.::.:......:: ..||:.|...|..::.|
Human   919 -------------SGQKIKSH--IQQLRVEEDVASDLVMKV-DALLSAQPKGDPRIEYQ------ 961

  Fly   458 QQQQPQQHLPEPSHSAHQQQPTESSMNCDL 487
                    ..|..|||.:.:|.|.....|:
Human   962 --------FFEDRHSAIKLRPKEGETYFDV 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	19/100 (19%)
		FN3	243..337	CDD:238020	26/136 (19%)
		fn3	343..430	CDD:394996	14/86 (16%)
		FN3	442..520	CDD:238020	9/45 (20%)
		R5-PTPc-1	704..907	CDD:350397
		R5-PTP-2	989..1182	CDD:350398
PTPRG	XP_016862450.1	alpha_CARP_receptor_like	67..359	CDD:239396
		FN3	388..478	CDD:238020
		PHA03169	<584..>742	CDD:223003	35/196 (18%)
		R-PTPc-G-1	888..1161	CDD:350505	24/133 (18%)
		R-PTP-G-2	1245..1449	CDD:350508