DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and PTPRF

DIOPT Version :9

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens


Alignment Length:1392 Identity:381/1392 - (27%)
Similarity:596/1392 - (42%) Gaps:359/1392 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 PATQAGRIFDVTNLDYVKVNAE-AGKNVTIPCPGVN-EHSLVDTL---------VWKTASTTIAQ 83
            ||.....:....::.|..|:.| .|::|.   .|:: |||..|.:         ||..|.|.:..
Human   635 PADSRNGVITQYSVAYEAVDGEDRGRHVV---DGISREHSSWDLVGLEKWTEYRVWVRAHTDVGP 696

  Fly    84 FANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHIPEAIVDLLVQDVPDPPERPLL 148
                                |.:.||.|.. |.|                    |||..|.|.:.
Human   697 --------------------GPESSPVLVR-TDE--------------------DVPSGPPRKVE 720

  Fly   149 IS-FTSRSVNLSW-------AHSQ--------------HPRNAPVTHFII------ETREGEDGI 185
            :. ..|.:|::.|       .|.|              .||..|:...::      ...|.||  
Human   721 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESED-- 783

  Fly   186 WEQLARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKP---IP 247
                   |..|      ::||||.|.||..:.|....|....||..  |||...|..|:|   |.
Human   784 -------YETT------ISGLTPETTYSVTVAAYTTKGDGARSKPK--IVTTTGAVPGRPTMMIS 833

  Fly   248 TTAHNTSSTSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVE-SHEIQNLQT 311
            |||.||:    .:.|.  ||..:.||.||||:.|...|.         .|.||:: ..:.|:...
Human   834 TTAMNTA----LLQWH--PPKELPGELLGYRLQYCRADE---------ARPNTIDFGKDDQHFTV 883

  Fly   312 YTQYKVTVQVF-----NPEGLGPETTILVMTDEGVPSK-PQNLTILDVSANSITMSWHPP--KNQ 368
            ...:|.|..:|     |..|||.|....:.|.|.:||. ||||.:..::.::..::|.||  ..:
Human   884 TGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAER 948

  Fly   369 NGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQI 433
            ||.|..|.|. ..|..:..|:     .::.|...|.|..|:|.|.|.:.|:|:|:|..|..|..|
Human   949 NGRIISYTVV-FRDINSQQEL-----QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSI 1007

  Fly   434 AQRT----------------------------------------------DVGGPS--------- 443
            ..||                                              :|.|.|         
Human  1008 QSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQ 1072

  Fly   444 ---------------------------APAIV----------------NLTC-HSQESITIRWRR 464
                                       ||.::                :|:. |.|:...:||  
Human  1073 PNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRW-- 1135

  Fly   465 PYEFYNTIDFYIIKT---RLAG-----------------------QDTHRDIRINASAKELETAM 503
                     |||:..   |:.|                       |......|....|:.|:..:
Human  1136 ---------FYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYV 1191

  Fly   504 ILQ----------------------NLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQP 546
            ..|                      .|:.:..|:..|.|:....::.|:.....:|:..::|:.|
Human  1192 AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTP 1256

  Fly   547 NCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHA-------AYYYLDDPPH 604
            ..::.:|         .:..:.|.:.:...||||::|..|:.||..|:       :....|....
Human  1257 AQQQEEP---------EMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA 1312

  Fly   605 HPNAP----QVDWEVPVKIGDEIRAA-----------VPVNEFAKHVASLHADGDIGFSREYEAI 654
            |.:.|    :::::.|   |..:.:.           :|:.:.|.::..|.|:..:.||:|||:|
Human  1313 HSSDPVEMRRLNYQTP---GSSVPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI 1374

  Fly   655 QNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRV---HLHPTPGQKKNLDYINANFIDGYQKG 716
            ..   ......|:|....||.||||.|:.|||||||   .:...||.    ||||||:||||:|.
Human  1375 DP---GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGS----DYINANYIDGYRKQ 1432

  Fly   717 HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEE 781
            :|:|.||||||:|...||||:||||.|.:||:|.|.|:.|.|||.|||..|.||.|:|||.|::.
Human  1433 NAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDT 1497

  Fly   782 EVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEA 846
            ..::||||||..:......:|::      :.|:.:..|||||.|::|.|:|.|:::..|.||.:|
Human  1498 VELATYTVRTFALHKSGSSEKRE------LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA 1556

  Fly   847 GPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE 911
            ||:||||||||||||.:||:||||::::.:..|:::|.:..:|:|||::||||:||:|:|:||:|
Human  1557 GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1621

  Fly   912 AIASGETNLMAE----QVEELKNCTP-----YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGA 967
            |...|.|.:.|.    .:::|....|     .:|.::|.:...:.......||....|..|||..
Human  1622 AATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLV 1686

  Fly   968 -IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVV 1031
             |.|.|.:||.|.|..|.:||||||||:|.|:|:.:.:|.||.|:|.:.:|||:|:|:||:..:|
Human  1687 NIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV 1751

  Fly  1032 LLSSLDDI---NFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHC 1093
            :|:.|.::   ...|:||.|.: ....::.|..:.:.|...|:.|:|.:...:|....|::....
Human  1752 MLTKLREMGREKCHQYWPAERS-ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQF 1815

  Fly  1094 PSWPEMSNPNS---IYDFIVDVHERCNDY-RNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTA 1154
            ..|||...|.:   ..|||..||:....: ::|||.:....|..:...|..:|.:...|.|....
Human  1816 TDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVV 1880

  Fly  1155 NVYQYAKLYHNKRPGVWTSSEDIRVIY 1181
            :::|..|....:||.:..:.:..::.|
Human  1881 DMFQTVKTLRTQRPAMVQTEDQYQLCY 1907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020 28/123 (23%)
fn3 249..331 CDD:278470 26/87 (30%)
FN3 342..437 CDD:238020 30/97 (31%)
FN3 442..520 CDD:238020 21/178 (12%)
PTPc 646..911 CDD:214550 131/267 (49%)
PTPc 676..911 CDD:238006 121/237 (51%)
PTPc 935..1186 CDD:214550 75/255 (29%)
PTPc 963..1169 CDD:238006 68/213 (32%)
PTPRFXP_005271136.1 I-set 33..124 CDD:254352
Ig 50..121 CDD:143165
I-set 135..225 CDD:254352
Ig2_RPTP_IIa_LAR_like 152..226 CDD:143215
IG_like 242..319 CDD:214653
Ig3_RPTP_IIa_LAR_like 250..318 CDD:143216
FN3 323..412 CDD:238020
FN3 419..511 CDD:238020
FN3 516..605 CDD:238020
fn3 613..700 CDD:278470 17/87 (20%)
FN3 714..820 CDD:238020 28/122 (23%)
FN3 825..914 CDD:238020 31/103 (30%)
FN3 923..1011 CDD:238020 28/93 (30%)
FN3 1020..>1079 CDD:238020 3/58 (5%)
PTPc 1366..1621 CDD:214550 131/267 (49%)
PTPc 1392..1621 CDD:238006 121/238 (51%)
PTPc 1657..1912 CDD:214550 74/252 (29%)
PTPc 1682..1912 CDD:238006 70/227 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001053
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.870

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