Protein Alignment Ptp99A and PTPRA

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 248/781 - (31%)
• Similarity: 390/781 - (49%)
• Gaps: 99/781 - (12%)

  Fly   479 TRLAGQDTHRDIRINA-------SAKELETAMILQ-NLTTNSYYEVKV-----------AAATFS 524
            |||....|...::..|       |...|..|.... |:|....|...|           .|:|.|
Human    43 TRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNS 107

  Fly   525 V---INPKKIVL--GKFSESRIIQLQPNC-------EKLQPLLRQSHNDYN-----LAVLVGIIF 572
            :   |:|....|  .:|:::|....:.|.       |...|.......|..     :||:|. :.
Human   108 IGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVA-LS 171

  Fly   573 SCFGIILIIMAFFLWSRKCF-----HAAYYYLD-------DPPHHP---NAPQVDWEVPVKIGDE 622
            |...|:.||:..::...|.:     |:..:.|.       :|...|   .:|..:.:.|
Human   172 SLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYP------ 230

  Fly   623 IRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLP-------CEHSQHPENKRKNRYL 680
               .:||::..:.:....||.:..|..|:.|         ||       ||.:...|||.||||:
Human   231 ---PLPVDKLEEEINRRMADDNKLFREEFNA---------LPACPIQATCEAASKEENKEKNRYV 283

  Fly   681 NITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII 745
            ||..||||||||.|..|...: |||||:||:|||:.:.||..|||..:|.:.||||||||..|.|
Human   284 NILPYDHSRVHLTPVEGVPDS-DYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 347

  Fly   746 VMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHL-KLKKKKQCNTEK 809
            ||:|||.||...||..|||..|..|||.|:|.:.:..|:..||||...|:.: .:..:|   .::
Human   348 VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRK---PQR 409

  Fly   810 LVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQ 874
            |:.|:|:|:|||.|.|..|:.:|.|:||..|.||..||.||||||||||||||::|:||||..:.
Human   410 LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMH 474

  Fly   875 QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL----MAEQVEELKNCTP-- 933
            .:..|:|:||:..|||||..:|||:.||:|::.||:|....|:|.|    :...::::.|..|
Human   475 TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGT 539

  Fly   934 ---YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASW 994
               .||:::|.:...:.::..:.:.....|..|||. .|.|.|.:||.:..|.||:.:||:|||:
Human   540 SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASF 604

  Fly   995 LHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDEATPIESDH 1056
            :.|:|:...:|.:|.|:.|||:|||:|:|:..:.::|:|:.|::   ...||:||.:......|
Human   605 IDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGD- 668

  Fly  1057 YRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDVHERCND 1118
            ..|:...:.....|..||.::.:.:::....::..|...|||:..|:   .:...|..|.::...
Human   669 ITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ 733

  Fly  1119 YRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI 1183
            ..|.||.:....|..:..||||:|::...::.....:|:|..|....:||.:..:.|.....|.:
Human   734 SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV 798

  Fly  1184 L 1184
            :
Human   799 V 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020
		fn3	343..430	CDD:394996
		FN3	442..520	CDD:238020	12/59 (20%)
		R5-PTPc-1	704..907	CDD:350397	103/203 (51%)
		R5-PTP-2	989..1182	CDD:350398	51/198 (26%)
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	140/316 (44%)
		R-PTPc-A-2	574..801	CDD:350471	62/227 (27%)