Protein Alignment Ptp99A and PTPN14

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_005392.2
• Gene: PTPN14 / 5784
• HGNCID: 9647
• Length: 1187
• Species: Homo sapiens
• Alignment Length: 958
• Identity: 217/958 - (22%)
• Similarity: 342/958 - (35%)
• Gaps: 306/958 - (31%)

  Fly   159 SWAHSQHPRNAPV----------THFIIETREGEDGIWE-QLARIYTKT------NATSYQVTGL 206
            :|:.|..||..|.          .|: .||...:|.|:. ....:|..:      |..:..||..
Human   323 TWSRSSLPRQQPYILPPVHVQCGEHY-SETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNG 386

  Fly   207 TPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWKAPPPDTIL 271
            :..:|:|...|..::..|......|...:...:......||:..|    :::.:....|.||
Human   387 SVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRH----SAIIVPSYRPTPD--- 444

  Fly   272 GEFLGYRITYRPRDRD--PNDTKEIYIRD-NTVESHEIQNLQ--TYTQ------YKVTVQVFNPE 325
                 |....|...|.  ..|::...:|: |.:.:|.....:  .|:|      :..||. :.|:
Human   445 -----YETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVP-YGPQ 503

  Fly   326 GL------------GPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVF 378
            |:            .|:..:       |||||        .|::|:.:...|:..|..:.|.|.:
Human   504 GVYSNKLVSPSDQRNPKNNV-------VPSKP--------GASAISHTVSTPELANMQLQGSHNY 553

  Fly   379 -------------------------------HIHDNQTG---------VEI-VKNSRNSVETLIH 402
                                           |.|...:|         |:: ||..:.....::|
Human   554 STAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVH 618

  Fly   403 FELQNL-RPYTDYRVIVKAFTTKNEGEPSDQIA---QRTDVGGPSAPAIVNLTCHSQESITIRWR 463
            ..||.: .|.|         .||:.|..:.:.:   ..:.|.|..|..:.:|........|:|.:
Human   619 QSLQEVSEPLT---------ATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQ 674

  Fly   464 RP-------YEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETA--------MILQNLTTNSY 513
            .|       :|......::..||   ..|....|..:.|.:|.|.|        |:.:.:.
Human   675 GPPEEGSGSHEVPQLPQYHHKKT---FSDATMLIHSSESEEEEEEAPESVPQIPMLREKME---- 732

  Fly   514 YEVKVAAATFSVIN--------PKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGI 570
            |..::.||...:.|        |:|.|    |...:.|.|.:   |.|.:.:
Human   733 YSAQLQAALARIPNKPPPEYPGPRKSV----SNGALRQDQAS---LPPAMAR------------- 777

  Fly   571 IFSCFGIILIIMAFFLWSRKCFH----AAYYYLDDPP-----------HHPNAPQVDWEV---PV 617
                             :|...|    |......|||           ..|:...|...|   ||
Human   778 -----------------ARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPV 825

  Fly   618 K---------IGDEI-----------------------------------------------RAA 626
            |         :.|.|                                               ...
Human   826 KERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATR 890

  Fly   627 VPVNEFAKHVASLHADGDIGFSREYEAI----QNECISDDLPCEHSQHPENKRKNRYLNITAYDH 687
            ||::|..:.:.....:|.: |: |||.|    .|...|.      :..|||..::|...:..|:.
Human   891 VPMDERFRTLKKKLEEGMV-FT-EYEQIPKKKANGIFST------AALPENAERSRIREVVPYEE 947

  Fly   688 SRVHLHPTPGQKKNLDYINANFID---GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMIT 749
            :||.|.||  ::.|..||||:.|.   |..:.| :|.||||||.|...||:|:|||.|.:|.|:|
Human   948 NRVELIPT--KENNTGYINASHIKVVVGGAEWH-YIATQGPLPHTCHDFWQMVWEQGVNVIAMVT 1009

  Fly   750 NLVERGRRKCDMYWPKDGVE----TYGVIQV--KLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTE 808
            ...|.||.|...||||.|.:    |||..:|  |...:.|  .|....|::|||      ....|
Human  1010 AEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSV--CYATTGLKVKHL------LSGQE 1066

  Fly   809 KLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSA----ANPAEAG------PIVVHCSAGVGRTGTY 863
            :.|:...||:|||||.|:.....|:::::..:    .|....|      ||||||||||||||..
Human  1067 RTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVL 1131

  Fly   864 IVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE 911
            |:.:.|:..::....|.|...||.:|.||.|::||..||.|::..|::
Human  1132 ILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQ 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	19/93 (20%)
		FN3	243..337	CDD:238020	20/116 (17%)
		fn3	343..430	CDD:394996	23/128 (18%)
		FN3	442..520	CDD:238020	16/92 (17%)
		R5-PTPc-1	704..907	CDD:350397	87/221 (39%)
		R5-PTP-2	989..1182	CDD:350398
PTPN14	NP_005392.2	B41	24..220	CDD:214604
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..531		6/35 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	671..690		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..824		7/36 (19%)
		PTPc-N14	896..1182	CDD:350447	107/303 (35%)