DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and PTPN12

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_002826.3	Gene:	PTPN12 / 5782	HGNCID:	9645	Length:	780	Species:	Homo sapiens

Alignment Length:	805	Identity:	193/805 - (23%)
Similarity:	307/805 - (38%)	Gaps:	211/805 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 VNEFAKHVASLHA---DGDIGFSREYEAI-------QNECISDDLPCEHSQHPENKRKNRYLNIT 683
            :.:|.:.|.::.:   :|:..|:|::..:       :.|.|   .|....:..||.:||||.:|.
Human     7 LRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKI---YPTATGEKEENVKKNRYKDIL 68

  Fly   684 AYDHSRVHLH-PTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVM 747
            .:|||||.|. .||.|  :.||||||||.|.....|::.|||||.:|...|||||||..|.||||
Human    69 PFDHSRVKLTLKTPSQ--DSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVM 131

  Fly   748 ITNLVERGRRKCDMYWPKDGVE--TYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKL 810
            .....|.||:||:.|||..|.:  |:...::...:|:..:.|.:|||.::..        |..:.
Human   132 ACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQ--------NESRR 188

  Fly   811 VYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD---AMLKQ 872
            :||:||.|||||..|.....:|:.:.........|..||.:|||||.||||....:|   .:||.
Human   189 LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKA 253

  Fly   873 IQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQ 937
            .:.....|||..::.:|.||:..|||:|||..:|.|:.:....
Human   254 GKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK---------------------- 296

  Fly   938 QYKNIIQFQPKDIHIASAMKQ-VNSIKNRGAIFPIEGSRVHL-TPKPGEDGSDYINASWLHGFRR 1000
                  |.|..:||.|..:.. ||.|.....:..||..:... .|||....|..:...
Human   297 ------QLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGD------- 348

  Fly  1001 LRDFIVTQHPMAH---------------TIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEAT 1050
            .::.|: |.|..|               |:...||....::.:.|:.:.|.:         ..:.
Human   349 AKEEIL-QPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSE---------QHSA 403

  Fly  1051 PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHER 1115
            .:..::.:...|...|:|.....|   :.::.:....:|.:.....|:..:.|::.:
Human   404 DLNRNYSKSTELPGKNESTIEQID---KKLERNLSFEIKKVPLQEGPKSFDGNTLLN-------- 457

  Fly  1116 CNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVI 1180
                |...|.|       ::.:.|....::...|..|..||...::          .|..|..|
Human   458 ----RGHAIKI-------KSASPCIADKISKPQELSSDLNVGDTSQ----------NSCVDCSV- 500

  Fly  1181 YNILSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNVAPLSSSSSTTPPPPSTPTPQPPQT 1245
                                |:...|:...|:            .|.:|.|||.|..........
Human   501 --------------------TQSNKVSVTPPE------------ESQNSDTPPRPDRLPLDEKGH 533

  Fly  1246 IQLSSHSPS------DLSHQISSTVANAGSPATASAGATPTTPM-TPTVPPTIPTIPSLASQNSL 1303
            :..|.|.|.      |||...||.: |..:..|.|...:|||.: ||
Human   534 VTWSFHGPENAIPIPDLSEGNSSDI-NYQTRKTVSLTPSPTTQVETP------------------ 579

  Fly  1304 TLTNANFHTVTNNAADLMEHQQQQMLALMQQQTQLQQQYNTHPQQHHNNVGDLLMNNADNSPTAS 1368
                           ||::|.....|.    :|.|.   .|:|.  |::..|....|:|.:.|
Human   580 ---------------DLVDHDNTSPLF----RTPLS---FTNPL--HSDDSDSDERNSDGAVT-- 618

  Fly  1369 PTITNNNHITNNNVTSAAATDAQNL 1393
               .|..:|:..:.|.:|||..:::
Human   619 ---QNKTNISTASATVSAATSTESI 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	105/277 (38%)
		PTPc	676..911	CDD:238006	98/240 (41%)
		PTPc	935..1186	CDD:214550	41/267 (15%)
		PTPc	963..1169	CDD:238006	30/221 (14%)
PTPN12	NP_002826.3	PTPc	28..292	CDD:214550	105/276 (38%)
		PTPc	60..292	CDD:238006	98/241 (41%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:27134172	63..67		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250	231..237		4/5 (80%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	345..438		13/112 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..639		43/196 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..725
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810