DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and PTPN11

DIOPT Version :10

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens


Alignment Length:376 Identity:130/376 - (34%)
Similarity:199/376 - (52%) Gaps:59/376 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 HHPNAPQVDWEVPVKIGDEIRAAVPVN-------EFAKHVASLHADGDI------GFSREYEAIQ 655
            |:...|.|:     .:|..::...|:|       |....|..|....:.      ||..|:|.:|
Human   196 HYKKNPMVE-----TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQ 255

  Fly   656 NECISDDLPC------EHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFI---- 710
            .:      .|      :..|..|||.||||.||..:||:||.||.....:...||||||.|    
Human   256 QQ------ECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEF 314

  Fly   711 ----DGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD-GVET 770
                :..:...::|.|||.|.:|.:.||||::::...:|||.|..||||:.||..|||.: .::.
Human   315 ETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKE 379

  Fly   771 YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQC----NTEKLVYQYHYTNWPDHGTPDHPLPV 831
            |||::|:.::|.....||:|     .|||.|..|.    |||:.|:|||:..|||||.|..|..|
Human   380 YGVMRVRNVKESAAHDYTLR-----ELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGV 439

  Fly   832 LNFVKK--SSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQ 891
            |:|:::  ....:..:|||:|||||||:|||||:||:|.::..|::|.:   ::|...::.:|:|
Human   440 LDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQ 504

  Fly   892 RNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNI 942
            |:.:||||.||.|::.|:...|.:.:..:..||..:.|.      .:|.||
Human   505 RSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKG------HEYTNI 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
FN3 243..337 CDD:238020
fn3 343..430 CDD:394996
FN3 442..520 CDD:238020
R5-PTPc-1 704..907 CDD:350397 90/220 (41%)
R5-PTP-2 989..1182 CDD:350398
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203
SH2_C-SH2_SHP_like 111..218 CDD:198185 5/26 (19%)
PTPc-N11 272..528 CDD:350453 108/260 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575
Blue background indicates that the domain is not in the aligned region.

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