DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and PTPN9

DIOPT Version :10

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_002824.1 Gene:PTPN9 / 5780 HGNCID:9661 Length:593 Species:Homo sapiens


Alignment Length:585 Identity:171/585 - (29%)
Similarity:269/585 - (45%) Gaps:121/585 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   405 LQNLRPYTDYRVIVKAFTTKNEG----EPSDQIAQRTDVGGPSAPAIVNLTCHSQESI---TIRW 462
            |:.:..:..||.     |.:.||    :|.::..:...:.|..  .|:|:...:..||   |.|.
Human    59 LRAIELFHSYRE-----TRRKEGIVKLKPHEEPLRSEILSGKF--TILNVRDPTGASIALFTARL 116

  Fly   463 RRPYEFYNTID----FYIIKTRLAGQDTHRDIRI--------NASAKELETAMILQNLTTNSY-- 513
            ..|::....:.    ||::...:...:|.|:..:        |.:..||:....:.||...::  
Human   117 HHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFPA 181

  Fly   514 --YEVKVAAA------TFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGI 570
              .:|.:..|      .:|:|:    :|.|......||:....|..|.|.|:...: ||.     
Human   182 RLKKVLIVGAPIWFRVPYSIIS----LLLKDKVRERIQILKTSEVTQHLPRECLPE-NLG----- 236

  Fly   571 IFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPN----------APQVDWE---VPVKIGDE 622
                 |.:.|.:|  .|:       :.:|.....||:          .|.:||:   ||   |..
Human   237 -----GYVKIDLA--TWN-------FQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVP---GPH 284

  Fly   623 IRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDH 687
               |:.:.|...:|   :|....|...|||.|:.|.......|  |..|.|..||||.::...|.
Human   285 ---AMTIQELVDYV---NARQKQGIYEEYEDIRRENPVGTFHC--SMSPGNLEKNRYGDVPCLDQ 341

  Fly   688 SRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLV 752
            :||.|....|..:. |||||:|:|||::.:|:|||||||.:|:..||.|:|||:|.:|||.|...
Human   342 TRVKLTKRSGHTQT-DYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE 405

  Fly   753 ERGRRKCDMYWP--KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYH 815
            |.|||||..|||  ||....:|.:.|..:..|.|:.|...||:|.:.:.::|:|      |..:.
Human   406 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQ------VTHFQ 464

  Fly   816 YTNWPDHGTPDHPLPVLNFVK-----------------KSSAANPAEAGPIVVHCSAGVGRTGTY 863
            :.:|||:|.|.....:::|::                 |.....|    |||||||||:|||||:
Human   465 FLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP----PIVVHCSAGIGRTGTF 525

  Fly   864 IVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE------AIASGETNLMA 922
            ..||..|.|:::...:|||..:..:|.||.|.:||.|||.|.:.|::|      .::||: ||:|
Human   526 CSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQ-NLLA 589

  Fly   923  922
            Human   590  589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
FN3 243..337 CDD:238020
fn3 343..430 CDD:394996 6/28 (21%)
FN3 442..520 CDD:238020 17/96 (18%)
R5-PTPc-1 704..907 CDD:350397 89/221 (40%)
R5-PTP-2 989..1182 CDD:350398
PTPN9NP_002824.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
CRAL_TRIO_N 20..68 CDD:215024 1/8 (13%)
SEC14 90..240 CDD:214706 32/166 (19%)
PTPc-N9 299..569 CDD:350391 109/282 (39%)
Blue background indicates that the domain is not in the aligned region.

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