DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and PTPN7

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_011508121.1	Gene:	PTPN7 / 5778	HGNCID:	9659	Length:	511	Species:	Homo sapiens

Alignment Length:	321	Identity:	104/321 - (32%)
Similarity:	155/321 - (48%)	Gaps:	74/321 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 EYEAIQNECIS-DDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGY 713
            |:..|.:..:| :||..     |.:..|:||..|.....|||.|.....|:.. ||||||:|.||
Human   205 EFLKIPSNFVSPEDLDI-----PGHASKDRYKTILPNPQSRVCLGRAQSQEDG-DYINANYIRGY 263

  Fly   714 Q-KGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVK 777
            . |...:|.||||:|:|...||.|:|::.|::|||:|.|.| |:.||..|||.: .||||..|::
Human   264 DGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE-GKEKCVHYWPTE-EETYGPFQIR 326

  Fly   778 LIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK----- 837
            :.:.:....||||.|.|::.:.::.        |....::.||||.||:...|:|..|.:
Human   327 IQDMKECPEYTVRQLTIQYQEERRS--------VKHILFSAWPDHQTPESAGPLLRLVAEVEESP 383

  Fly   838 SSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQR---------- 892
            .:||:|   ||||||||||:||||.:|......:|::.:..|::.|.:..:|..|
Human   384 ETAAHP---GPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRLLERRKLEAQ 445

  Fly   893 ------------------------------------NFLVQTEEQYIFLHDALVEAIASGE 917
                                                ..::||.|||.|||..|  |:.:|:
Human   446 EYSWPDPRLQRSGFVPGAEWIKEDQVSTWGITPQHVGGMIQTAEQYQFLHHTL--ALYAGQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	102/313 (33%)
		PTPc	676..911	CDD:238006	96/286 (34%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
PTPN7	XP_011508121.1	PTPc	201..499	CDD:214550	102/314 (32%)
PTPN7	XP_011508121.1	PTPc	227..499	CDD:238006	96/287 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810