DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and PTPN1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_002818.1	Gene:	PTPN1 / 5770	HGNCID:	9642	Length:	435	Species:	Homo sapiens

Alignment Length:	377	Identity:	118/377 - (31%)
Similarity:	197/377 - (52%)	Gaps:	56/377 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 EFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPT 695
            |..|....:...|  .::..|:.|::|  :.|.||..::.|:||.:|||.:::.:||||:.||
Human     2 EMEKEFEQIDKSG--SWAAIYQDIRHE--ASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH-- 60

  Fly   696 PGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCD 760
              |:.| |||||:.|...:...::|.||||||:|...||.|:|||:...:||:..::|:|..||.
Human    61 --QEDN-DYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCA 122

  Fly   761 MYWP----KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPD 821
            .|||    |:.:.....:::.||.|::.|.||||.|::::|..::.::      :..:|||.|||
Human   123 QYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETRE------ILHFHYTTWPD 181

  Fly   822 HGTPDHPLPVLNF---VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQK---NIVN 880
            .|.|:.|...|||   |::|.:.:| |.||:|||||||:||:||:.:.|..|..:.::   :.|:
Human   182 FGVPESPASFLNFLFKVRESGSLSP-EHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVD 245

  Fly   881 VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNII-- 943
            :...|..:|..|..|:||.:|..|.:.|::|    |...:|.:.         .::.|:|.:.
Human   246 IKKVLLEMRKFRMGLIQTADQLRFSYLAVIE----GAKFIMGDS---------SVQDQWKELSHE 297

  Fly   944 QFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWL 995
            ..:|...||....:....|               |.|..|:....:.|..|:
Human   298 DLEPPPEHIPPPPRPPKRI---------------LEPHNGKCREFFPNHQWV 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	101/274 (37%)
		PTPc	676..911	CDD:238006	92/244 (38%)
		PTPc	935..1186	CDD:214550	11/63 (17%)
		PTPc	963..1169	CDD:238006	5/33 (15%)
PTPN1	NP_002818.1	PTPc	3..276	CDD:214550	103/288 (36%)
		Substrate binding. /evidence=ECO:0000250	215..221		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810