Protein Alignment Ptp99A and ca16b

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_021332937.1
• Gene: ca16b / 569183
• ZFINID: ZDB-GENE-080818-1
• Length: 1382
• Species: Danio rerio
• Alignment Length: 1265
• Identity: 384/1265 - (30%)
• Similarity: 600/1265 - (47%)
• Gaps: 268/1265 - (21%)

  Fly    53 GKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFA------------------NRIPL--LHSPRI- 96
            |...|.||..|.|..:....|:.:.....|.::                  |..|:  |.|.||
Zfish   249 GSLTTPPCSKVVEWIIFSRPVYLSYHQLEAFYSIFTTEQQDHVKSVDYLRNNHRPIQDLDSRRIF 313

  Fly    97 -QLLSDNFGLQFSPSLASDTSEYICLVNDRHIPE----------AIVDLLVQDVPDPPERPLLIS 150
             ..|.|.:..:...|.|...:..:|    ..||:          |:|  |..|.|.....|.::.
Zfish   314 KSALMDAWMPETMASAADTETSRVC----SSIPDNMKLHPLNRTALV--LTWDRPSAVYHPPIVG 372

  Fly   151 FTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVTGLTPFTVYSFR 215
            |.   |:.||...:.|.....|.                    :..::|...:|.::|..:|.||
Zfish   373 FL---VSYSWVKDEMPFEKTFTQ--------------------SSEHSTRAVITLVSPDVLYLFR 414

  Fly   216 LLAVNKLGISPPSKESYYIVTL-------------REAPTGKPIPTTAHNTSSTSVYISWKAPPP 267
            :.|     :....:.|.:..||             |...||  :||.:..:|:....||
Zfish   415 VQA-----LCQRDQRSDFSQTLLFKANTTRIFEGTRIVKTG--MPTVSPASSADMAPIS------ 466

  Fly   268 DTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETT 332
                                                   ....|:|.          .|| |.:.
Zfish   467 ---------------------------------------SGSSTWTS----------AGL-PFSF 481

  Fly   333 ILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKN----- 392
            :.:.|..|.||.....|:..|..:::........:...::.| ..:..|...||....::
Zfish   482 VSMATGMGPPSSGGQATVASVVTSTLLAGLGFSGSVISSLPG-SFWPTHSTNTGPSPTQHPATPT 545

  Fly   393 -----SRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTD-------------- 438
                 |.:|.:|....|.:......|         .:.|.|..::..||.:
Zfish   546 AENSPSEDSTDTQNKLEEEEEHKKED---------DEEEEEEEEEEEQRDEEKKKKGKDVTVKDK 601

  Fly   439 ---VGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAG-------QDTHR----- 488
               |..|:||  :..:.|...      .||....:|:....::.:::|       :|:.:
Zfish   602 KQTVQKPTAP--IPTSKHRDR------ERPDAESSTLTPAEVEEQVSGATERPDAEDSSKATWQD 658

  Fly   489 --DIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKL 551
              |::|.:|:  .|::.:......|..|.:.....:.|.::...:    .|.||:       |.:
Zfish   659 DNDMQIPSSS--TESSKLSDEEKANWPYYINTERNSISTVSRDSV----SSSSRM-------EWI 710

  Fly   552 QPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQV---DW 613
            .||:          |:..:...|   :::::|..::.|:.|..|::|::|    .|:|:|   |.
Zfish   711 IPLM----------VVSALTLLC---LIMLLAVLVYWRRFFQTAHFYIED----RNSPRVIHNDS 758

  Fly   614 EVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISD-DLPCEHSQHPENKRKN 677
            ...:...|::. |:||.:|.||:..||::...|||:|::.:|: |.|: .:..|||.|||||.||
Zfish   759 FPIISTADDLE-AMPVRQFIKHIMELHSNNRHGFSQEFDEVQH-CTSEMKITAEHSNHPENKHKN 821

  Fly   678 RYLNITAYDHSRVHLHPTPGQ-KKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQR 741
            ||:||.|||||||.|...||: .|:.||||||::|||::..|:|..||||..||:.||||||||.
Zfish   822 RYINIVAYDHSRVKLQQLPGKDSKHSDYINANYVDGYKRARAYIAAQGPLKSTFEDFWRMIWEQN 886

  Fly   742 VAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKK-KKQC 805
            ..:|||||||||:||||||.|||.:..|.||.|.|.|...:|.:.||:|...:::.|||| :|..
Zfish   887 TTVIVMITNLVEKGRRKCDQYWPSENSEVYGNIMVTLKSTKVYAYYTLRHFIVRNSKLKKGQKGR 951

  Fly   806 NTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAML 870
            ..|:||.|||||.|||.|.|::.||||.|:.:|:..:.:..||::|||||||||||||||:|:||
Zfish   952 QNERLVLQYHYTQWPDMGVPEYTLPVLKFISRSTVTHASSTGPVLVHCSAGVGRTGTYIVIDSML 1016

  Fly   871 KQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKN--CTP 933
            |||:.:..|||.|||:|||.|||:|||||||:||:||||:||:.|.:|.:.|.|:....|  .||
Zfish  1017 KQIKDRGSVNVLGFLKHIREQRNYLVQTEEQFIFIHDALMEAVLSKDTEVSAWQLHTYTNSLLTP 1081

  Fly   934 ------YLEQQYKNIIQFQPKDIHIA---SAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSD 988
                  .:::.:|.:.|.   :.|:|   |..|:.|..||| .|:.|.|.:||.|:|.||..|:|
Zfish  1082 SPTGHTRMDKHFKLLTQC---NAHLAECLSGQKECNKEKNRTSAVLPTERARVALSPLPGLKGTD 1143

  Fly   989 YINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ----FWPDEA 1049
            |||||::.|:.|..:||:||||:.||..|||:|:||||||.:|:|.  |::...:    :||...
Zfish  1144 YINASYIMGYYRSNEFIITQHPLPHTTTDFWRMIWDHNAQVIVMLP--DNLGLTEDEFVYWPSRE 1206

  Fly  1050 TPIESDHYRVKFLNK-----TNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEM-SNPNSIYDF 1108
            .|:....:.|..:|.     :|:...:..||::::.||||.|.|:...||:||:. ::.:|.::.
Zfish  1207 EPMNCIAFTVTLINTDRLCLSNEEQLIIHDFILEATQDDYVLEVRHFQCPNWPDPDASISSTFEL 1271

  Fly  1109 IVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTS 1173
            |..:.|.... |:||.::.|.:|...|.||||:::|:.::|..|..:|||.||:.:..||||:|.
Zfish  1272 INIIKEEAMT-RDGPTIVHDEFGAVSAGTFCALTTLSQQLENESAVDVYQVAKMINLMRPGVFTE 1335

  Fly  1174 SEDIRVIYNILSFLPGNLNLLKRTALRTEF 1203
            .|....:|..:      |:|:.....|..|
Zfish  1336 IEHYHYLYQAM------LSLVSSKDFRFGF 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	16/95 (17%)
		FN3	243..337	CDD:238020	11/93 (12%)
		fn3	343..430	CDD:394996	14/96 (15%)
		FN3	442..520	CDD:238020	15/91 (16%)
		R5-PTPc-1	704..907	CDD:350397	120/203 (59%)
		R5-PTP-2	989..1182	CDD:350398	73/202 (36%)
ca16b	XP_021332937.1	alpha_CARP_receptor_like	62..314	CDD:239396	14/64 (22%)
		FN3	340..417	CDD:214495	20/101 (20%)
		PTP_DSP_cys	791..1060	CDD:475123	158/269 (59%)
		R-PTP-G-2	1144..1348	CDD:350508	74/212 (35%)