DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and ptpn22

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001092890.1	Gene:	ptpn22 / 565606	ZFINID:	ZDB-GENE-060503-458	Length:	887	Species:	Danio rerio

Alignment Length:	792	Identity:	187/792 - (23%)
Similarity:	312/792 - (39%)	Gaps:	199/792 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 GFSREYEAIQNEC----ISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYIN 706
            ||:.|:..::.:.    .....|...:...:|.:||||.:|..:|||||.|.... .|.:.||||
Zfish    28 GFAGEFLKLKRQSTKYRAERTYPTTAADKQDNVKKNRYKDIVPFDHSRVKLSLFT-SKNDTDYIN 91

  Fly   707 ANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVE 769
            |:||.|.....|:|.|||||.:|...|||||||..:.:|||:....|.||:||:.|||  |..|.
Zfish    92 ASFIKGVSGSKAYIATQGPLSNTVLDFWRMIWEYNIQVIVMVCREFEMGRKKCERYWPESKGDVF 156

  Fly   770 TYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNF 834
            ......:....:|....|..|||::...:..::        :.|.||.||||||.||....:|..
Zfish   157 VCEAFTILYESDENKGDYLTRTLKVTFKQESRR--------LKQLHYVNWPDHGVPDSIPAILEL 213

  Fly   835 VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLV 896
            :::.......|..||.:|||||.||||....:|.....::::.|   .::|..::.:|.||..:|
Zfish   214 LQEMRIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVV 278

  Fly   897 QTEEQYIFLHD----------ALVEA----IASGETNLMAEQVEELKNCTPYLEQ---------- 937
            ||:|||..::.          |.:||    :....:..|.....||.:.:.:.:|
Zfish   279 QTKEQYELVYRTIKLLFERYLAALEAPSNKVPDSSSPAMLSSGSELSDISDFSDQEQTEHRNDEI 343

  Fly   938 ---QYKNIIQ-----FQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINA-- 992
               :|.:::|     .||   |..:...:|.|.|              |||      :|..||
Zfish   344 RVDEYNHVMQNSASWQQP---HSQTFSPEVMSNK--------------LTP------ADLHNARC 385

  Fly   993 SWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQF--WPD--EATPIE 1053
            .|:    ::.|...:..|:..|  ||..........:..|.::...::.:.:  |.:  ||:|:.
Zfish   386 EWV----QITDQSSSIAPVLQT--DFTTCGSQKPEASTSLSTTSTQVSCSNYLEWVENQEASPVV 444

  Fly  1054 SDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCND 1118
            .||            :.|....:..:::|.|       ..|..|..||..|:.:  ...||   .
Zfish   445 KDH------------NTVIPSTLCLTVEDPY-------FGPESPPGSNNPSVLN--CTAHE---I 485

  Fly  1119 YRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI 1183
            :...|...:..         .|:::.|:||            ..:.:...|..|.|.|......:
Zfish   486 WTEKPCFTIPS---------LALNNQALEM------------PKHDSNNKGGNTLSSDEESPPPL 529

  Fly  1184 LSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNVAPLSSSSST----TPPPPSTPTPQ-PP 1243
            ....|.:..:...|:.::..|...|      |::.:.|.|.|:||.:    .||.|..|.|: .|
Zfish   530 PERTPESFIMADETSGQSNNEKSET------SELLTLVIPTSTSSESVNRDNPPSPVPPLPERTP 588

  Fly  1244 QTIQL----------SSHSPSDLSHQISSTVANAGSP--------------------ATASAGAT 1278
            ::.::          :...|.::..::..::..:|..                    .:..|.:|
Zfish   589 ESFEMAMDADLVQNVTQEKPQEVVMRVGKSLEWSGQTNEGQTDMKRSWSRSKSLKLRMSLPASST 653

  Fly  1279 PTTPMTPT---VPPTI----------------PTIPSLASQNSLT-----LTNANF--HT--VTN 1315
            |.:|:|.|   .||.:                .|..|...:.|||     .|..:|  ||  |:|
Zfish   654 PLSPITITSHSPPPLLYKHTQDTFLDTSTSHGQTFNSFQGKESLTPPLPERTPESFILHTEKVSN 718

  Fly  1316 NAADLMEHQQQQ 1327
            |:|.....:.:|
Zfish   719 NSAPCQPVEAEQ 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	95/283 (34%)
		PTPc	676..911	CDD:238006	90/249 (36%)
		PTPc	935..1186	CDD:214550	47/274 (17%)
		PTPc	963..1169	CDD:238006	35/211 (17%)
ptpn22	NP_001092890.1	Y_phosphatase	59..291	CDD:278528	90/240 (38%)
ptpn22	NP_001092890.1	PTPc	61..291	CDD:238006	89/238 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910