Protein Alignment Ptp99A and ptprja

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001129714.1
• Gene: ptprja / 559679
• ZFINID: ZDB-GENE-030131-8301
• Length: 1650
• Species: Danio rerio
• Alignment Length: 845
• Identity: 214/845 - (25%)
• Similarity: 352/845 - (41%)
• Gaps: 169/845 - (20%)

  Fly   140 PDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVT 204
            |:.|....::...:.||.|.|..:|:.......:.:        ..|.........|...:..:.
Zfish   879 PNSPGMITVLFKNTHSVLLHWDIAQNMTPGSFNYSL--------SFWSSKNNSLYLTPNNTLLLD 935

  Fly   205 GLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWK-APPPD 268
            ||...|.|:..|..|..|.:...|.. |.:.|:.:......:.:|..||.|    ::|| ...|.
Zfish   936 GLQSGTPYNVSLATVGPLNLQSESMR-YNVTTMPDPVKNLKVVSTTTNTIS----VTWKMVDVPK 995

  Fly   269 TILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQ--VF-NPEGLGPE 330
            .::               ..|:..:|...:|..    |.|||..|||.::||  .| |.||   |
Zfish   996 YVV---------------SVNNAVKITSSNNMT----IHNLQPSTQYNISVQSSTFDNTEG---E 1038

  Fly   331 TTILVMTDEGVPSKPQNLTIL--DVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNS 393
            ...|....:..|  .:|:|.:  :::...:.:.|:.|      :.||..|.::.:.:..|..||
Zfish  1039 AVCLQDCTDAAP--VENVTCVGPNLTLPMLNLFWNHP------LGGYMNFEVNLSSSISEKTKN- 1094

  Fly   394 RNSVETLIHFELQNLRPYTDYRVIV------KAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTC 452
                   :::....|:....|.|.:      |:.|.||       |:..|....|..|.|...:.
Zfish  1095 -------LNYNFTGLKYNKTYSVTLRTLGCGKSSTVKN-------ISCTTGFTNPVVPKITAASV 1145

  Fly   453 HSQE----SITIRWRRPYEFYNTIDFY---------------------IIKT----RLAGQDTH- 487
            ..|:    ::.|:.....:...|:..|                     ::||    :....||.
Zfish  1146 SEQQYNKFALVIQSDAFNDSNGTVCSYGLLVSSGSFDCLDNNQNYNQCLLKTYDDWKAKQSDTFL 1210

  Fly   488 RDIRINASAKELETAMILQNLTTNSY----------YEVKVAAATFSVINPKKIVLGK----FSE 538
            ..::.|.|..||||.:|......|.|          |...:.|.|...:...|:.:.|    .|.
Zfish  1211 AVVKTNVSKSELETIIIGDGSKWNKYTNGELNAKGTYNFAIVAFTLLEVKDGKVDVSKSYYSVSA 1275

  Fly   539 SRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPP 603
            .:.:.|..|                 .|::|...:..|:.:||:...:....|
Zfish  1276 YQSVTLPEN-----------------PVVIGGAAAGVGVTVIIVVIIIGIVAC------------ 1311

  Fly   604 HHPNAPQVDWEVPV-----KIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDL 663
            ......:|...||:     |:.|.|:    |.::..:.....||...||:.|:|.::...|:...
Zfish  1312 TRKKRKEVSNSVPIHSLRNKVSDPIK----VEDYEAYYKRQRADSFCGFAEEFEDLRPVGINQSK 1372

  Fly   664 PCEHSQHPENKRKNRYLNITAYDHSRVHLH--PTPGQKKNLDYINANFIDGYQKGHAFIGTQGPL 726
            ..  :..||||.||||.|:..||.|||.|.  .:|..    ||||||::.||.....||..||||
Zfish  1373 TV--AVFPENKAKNRYNNVLPYDSSRVKLSVLSSPFD----DYINANYMPGYITKKEFIAAQGPL 1431

  Fly   727 PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRT 791
            |.|.:.|||:|||:.|..|||:|...|:||.||:.|||.: ::|:..:.|..|.:..:..:|:|.
Zfish  1432 PGTVNDFWRLIWEKNVHTIVMLTKCNEQGRVKCEEYWPAE-MKTFSNLTVTTISDIPLEDWTLRD 1495

  Fly   792 LQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNF--VKKSSAANPAEAGPIVVHCS 854
            .::|::|..:.:.      |..:|:|.|||||.|:....::||  :.:......:...|.:||||
Zfish  1496 FEVKNMKTAEIRS------VRHFHFTAWPDHGVPETTELLINFRHLVREHMDEYSRHSPTLVHCS 1554

  Fly   855 AGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN 919
            ||||||||:|.:|.::.||::..:|:|:|.:..:|..|..:||||:||:||:...::.|.|...|
Zfish  1555 AGVGRTGTFIAIDRLIFQIERDGVVDVYGIIHDLRMHRPLMVQTEDQYVFLNQCAMDIIKSRTGN 1619

  Fly   920  919
            Zfish  1620  1619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	18/95 (19%)
		FN3	243..337	CDD:238020	25/97 (26%)
		fn3	343..430	CDD:394996	17/94 (18%)
		FN3	442..520	CDD:238020	21/117 (18%)
		R5-PTPc-1	704..907	CDD:350397	82/204 (40%)
		R5-PTP-2	989..1182	CDD:350398
ptprja	NP_001129714.1	fn3	102..168	CDD:394996
		FN3	158..676	CDD:442628
		FN3	707..783	CDD:473895
		FN3	968..1031	CDD:214495	19/85 (22%)
		PTP_tm	1157..1279	CDD:465889	22/121 (18%)
		R-PTPc-J	1384..1611	CDD:350463	94/237 (40%)