Protein Alignment Ptp99A and ptprk

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_021324241.1
• Gene: ptprk / 555348
• ZFINID: ZDB-GENE-030131-9834
• Length: 1496
• Species: Danio rerio
• Alignment Length: 1431
• Identity: 353/1431 - (24%)
• Similarity: 572/1431 - (39%)
• Gaps: 398/1431 - (27%)

  Fly    37 IFDVTNLDY-------------VKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRI 88
            |.|:..|.|             |:||  ||:|.|..|. ......|:..:|.....     ...|
Zfish   181 IDDIQVLSYPCDKSPHFLRLGDVEVN--AGQNATFQCI-ATVRDAVNNKLWLQRRN-----GEDI 237

  Fly    89 PLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHIP--EAIVDLLVQDVPDPPERP----- 146
            |:.....|.........:.....:.|...|.|:.......  .....|:|::.|.|...|
Zfish   238 PVAEKKNINHRKFAASFRLKEVSSQDQDLYRCVTQSERGSGVSNFAGLIVREPPRPIAPPQLLGV 302

  Fly   147 ----LLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVTGLT 207
                |||...:.|:.         .:.|:....:|.|. ..|.|.:...:    |:.:|::..|.
Zfish   303 GPTYLLIQLNANSIF---------GDGPIILKEVEYRM-TSGSWTETHAV----NSPNYKLWHLD 353

  Fly   208 PFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTS--------------- 257
            |.|.|..|:|      ::.|.          |..||:|.|.....|....
Zfish   354 PDTEYEIRVL------LTRPG----------EGGTGQPGPALITRTKCAEPMRTPKSLKIAETQA 402

  Fly   258 --VYISWKAPPPDTILGEFLGYRIT------------YRPRDRDPNDTK-EIYIRDNTVESHEIQ 307
              :.:.|          |.|||.||            |.   :.||.:| :....|.....|.:.
Zfish   403 RFIAVDW----------ESLGYNITRCHTFNVTICYHYH---KTPNHSKADCLEMDPKAPRHVVG 454

  Fly   308 NLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSK-PQNLTILDVSANSITMSWHPPKNQNGA 371
            ||...|...:.:.:.||||.......|:.|.|.||.. |:.......|.:.|::.|..|...||.
Zfish   455 NLPPNTNVSLKMILTNPEGRKESDETLIQTQEDVPGPVPKEFVRSTPSEDKISLQWKEPLEPNGI 519

  Fly   372 IAGYHVFH--IHDNQTGVEIVK---------NSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKN 425
            |..|.:.:  :|.....|.:::         |:.....||:|       |.|.|:.:::|.|:|.
Zfish   520 ITQYEISYSSVHSFDPSVPLLRPPLLVSLPWNTSRYNFTLLH-------PGTTYQFLIRASTSKG 577

  Fly   426 EGEPSDQIAQRTDVGGPS------APAIVNLTCHSQESITIRWR------RPYEFYNTIDFYIIK 478
            .|.|: .:...|::..|:      :.|.:|.|.   .:||:..:      .|...|..:...|..
Zfish   578 FGPPT-TLNVTTNISAPTLEEYDGSEASLNETA---TTITVLLKPAQAKGAPISAYQIVVKEINP 638

  Fly   479 TR----LAGQDTHRDIRINASA---------------KELETAM---ILQNLTTNSYYEVKVAAA 521
            .|    ..|.:.:|:.....||               :.|:..:   :..|.|.:.|:...:|
Zfish   639 HRGRREAGGGECYREPVSYQSAVSSGLPYYFAAEIPPRNLQEPLPFTVGDNKTYHGYWNAPLA-- 701

  Fly   522 TFSVINPKKIV---------LGKFSESRIIQL-------QPNCEKLQPLLRQSHNDYNLAVLVGI 570
                  |:|..         :.|.|:::.::|       :|  |.:....:|:.....:|.:...
Zfish   702 ------PRKDYNIYFQAVSRVEKESKTQCLKLAFKGATEEP--EVIPDPAKQTDQVVKIAGISAA 758

  Fly   571 IFSCFGIILIIMAFFLWSRKCFHAAYYYL------------------------------------ 599
            :. .|.:::::....|..|:.:::..|||
Zfish   759 VL-VFILLVLVAILLLKKRRSYYSYSYYLKLAKKRKDAIGNTRQEMTHMVNSMDRSYADQSTLHA 822

  Fly   600 DDP-------PHH-----PNAPQV------------------------------DWEVPVKIGDE 622
            ::|       .|:     ||.|.|                              ..|.|.:.| :
Zfish   823 EEPMTVTFMDSHNFSNRLPNEPLVPTAVLDENHTAAAAAAENSRLLDIPRYHCEGTESPYQTG-Q 886

  Fly   623 IRAAVPVNEFAKHVASLHADGDIGFSREYEA-IQNECISDDLPCEHSQHPENKRKNRYLNITAYD 686
            :..|:.|.:..:|:..:......||..|||: .:.:..|.|.    ::..:|:.||||.||.|||
Zfish   887 LHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDA----AKKEQNRTKNRYGNIIAYD 947

  Fly   687 HSRVHLHPTPGQKKNLDYINANFI---------------------------DGYQKGHAFIGTQG 724
            ||||.|.|......: ||||||:|                           ||||:...:|.|||
Zfish   948 HSRVILQPMEDDPSS-DYINANYIDVSGDAASSSIGERVRNVSPSLIWLYRDGYQRPSHYIATQG 1011

  Fly   725 PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTV 789
            |:.:|...||||||:::.|.|||:|||||.||.||..||| |..|.||..:|..:|.|.::.|.|
Zfish  1012 PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDAEVYGDFKVTFVEVEPLAEYVV 1075

  Fly   790 RTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCS 854
            ||..:      :::..|..:.|.|:|:|.|||||.|.|...:|:|:::...:||..|||||||||
Zfish  1076 RTFTL------ERRGFNEVREVKQFHFTGWPDHGVPYHATGLLSFIRRVKMSNPPTAGPIVVHCS 1134

  Fly   855 AGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN 919
            ||.||||.|||:|.||...:::.:|:::..::.:|::|..:|||||||||:|||::||...|||.
Zfish  1135 AGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETA 1199

  Fly   920 L-----------------------MAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNS 961
            :                       :.::.:.|.:.||          |.||:|..||...:  |.
Zfish  1200 IPVCEFKAAYYDMIRIDSQSNSSHLKDEFQTLNSVTP----------QPQPEDCSIALLPR--NH 1252

  Fly   962 IKNR-----------GAIFPIEGSRVHLTPKPGEDGSDYINASWL------HGFRRLRDFIVTQH 1009
            .|||           ..:..|:|           :.|:||||:.:      ..:|:...||||||
Zfish  1253 DKNRFMDNLPPDRCLPFLITIDG-----------ESSNYINAALMDPSEEYQSYRQPAAFIVTQH 1306

  Fly  1010 PMAHTIKDFWQMVWDHNAQTVVLLSSLD-DINFAQFWPDEAT----PIESDHYRVKFLNKTNKSD 1069
            |:.:|:||||::|:|:...::|:|:.:| .....|:||:|..    |::.|     .::.:...|
Zfish  1307 PLPNTVKDFWRLVYDYGCTSIVMLNEIDLAQGCPQYWPEEGMLRYGPVQVD-----CISCSMDCD 1366

  Fly  1070 YVSRDFVIQSI---QDDYELTVKMLHCPSW------PEMSNPNSIYDFIVDV---HERCNDYRNG 1122
            .:||.|.|.::   |:.| |.|:......|      |  ::..|....|:.|   .|.|.: .:|
Zfish  1367 VISRLFRICNLTRPQEGY-LMVRQFQYLGWAGHREVP--ASKRSFLKLILQVDKWQEECEE-GDG 1427

  Fly  1123 PIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI-LSF 1186
            ..:|....||.::..|||||.:...::..:..:|:...|...|.:|.:..|.|..|..|:: |.|
Zfish  1428 RTIIHCLNGGGRSGMFCAISIVCEMIKRQNVVDVFHAVKSLRNSKPNMVDSPEQYRFCYDLALEF 1492

  Fly  1187 L 1187
            :
Zfish  1493 I 1493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	21/104 (20%)
		FN3	243..337	CDD:238020	25/123 (20%)
		fn3	343..430	CDD:394996	22/98 (22%)
		FN3	442..520	CDD:238020	18/111 (16%)
		R5-PTPc-1	704..907	CDD:350397	98/229 (43%)
		R5-PTP-2	989..1182	CDD:350398	60/215 (28%)
ptprk	XP_021324241.1	MAM	30..191	CDD:214533	4/9 (44%)
		IG_like	201..282	CDD:214653	16/88 (18%)
		Ig strand B	211..215	CDD:409549	1/3 (33%)
		Ig strand C	225..231	CDD:409549	1/5 (20%)
		Ig strand E	249..256	CDD:409549	0/6 (0%)
		Ig strand F	266..271	CDD:409549	2/4 (50%)
		fn3	293..370	CDD:394996	20/106 (19%)
		fn3	491..582	CDD:394996	22/97 (23%)
		PTP_DSP_cys	895..1194	CDD:475123	128/310 (41%)
		R-PTPc-K-2	1280..1491	CDD:350484	61/219 (28%)