Protein Alignment Ptp99A and ptprz1b

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_073803012.1
• Gene: ptprz1b / 553019
• ZFINID: ZDB-GENE-050506-100
• Length: 1457
• Species: Danio rerio
• Alignment Length: 1162
• Identity: 363/1162 - (31%)
• Similarity: 551/1162 - (47%)
• Gaps: 258/1162 - (22%)

  Fly   240 AP--TGKPIPTTAHNTSSTSVYISWKAPPP--DTILGEFLGYRITYRPRDRDPNDTKEIYIRDNT 300
            ||  :.:|....|.:.:.|.:.::|:.|..  ||::..   |.:||: |.:..|..|:.|:.|..
Zfish   310 APMCSSEPQNVQADSQNFTGIVVTWERPRAVYDTVIER---YSVTYQ-RLQGQNPPKQQYLTDGD 370

  Fly   301 VE-SHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTD---EGVPSKPQNLTILDVS-----AN 356
            .: ...|.||...:.|.|.|......||..:.:..|:.|   |...::|.....|..|     .:
Zfish   371 QDVGAIIHNLLANSSYVVQVVALCMNGLTGKMSDQVIVDMPFEDPVNEPDPYGDLAESEEYNEEH 435

  Fly   357 SITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEI-------------------------------- 389
            :...|..||..:         |.|.|:.:.:.|
Zfish   436 TSAPSSKPPPGR---------FLIRDSGSSISITTSTDQPGFLFPVSRTTPITVRRKITEESSLS 491

  Fly   390 ---VKNSRNSVET------LI-----HFELQNLRPYTD--YRVIVKAFTTK-----NEGEPSDQI 433
               |:|.....||      |:     ||...| ...||  |..::.:.||.     |.....||.
Zfish   492 QPPVQNKSRKNETKRPANRLLPDDSGHFPQSN-TVVTDVYYEDVLNSSTTNITPTINNNLLIDQN 555

  Fly   434 AQRTDVGGPSAPA----IVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINA 494
            .::.....|..||    ..|.|..|..|.:::             .|.:|.   |....|:.:.|
Zfish   556 TEKASTSPPKQPANESSTANATTGSSLSASMK-------------IISQTT---QPLFNDVFVTA 604

  Fly   495 SAKELETAMILQNLTTNSYYEVKVAAATF-----SVINPKKIVLGKFS----------------- 537
            ::...|..:::.:.|  |.||....:.|.     |...|.....|:||
Zfish   605 TSFNNERVLMVSDAT--SLYESSTRSPTIILEEGSAHFPPSDGQGEFSGSGSAIFLEELDREWEL 667

  Fly   538 -ESRIIQLQPNCEKLQ------------------------------------------------- 552
             ::|:.....:..|.|
Zfish   668 EQTRMAPKNADPRKTQEENHEGLPSTFFFESEREASSTYKPQNQDFLSWVTWSAESDSGSGQGGS 732

  Fly   553 --------------PLL---RQSHNDYN-----------------------LAVLVGIIFSCFGI 577
                          |.|   .::|.:.:                       ||::..:...|
Zfish   733 MISQTEDIPIQLIIPKLNIQEENHAEASNSSPESRVGMVGGTETEKRAVVPLAIVSTLTVLC--- 794

  Fly   578 ILIIMAFFLWSRKCFHAAYYYLDD--PPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLH 640
            :::::...::.|:||..|::|::|  .....:||    ..|:.:..|...|:||.:|.||||.||
Zfish   795 LVVLVGILIYWRRCFQTAHFYVEDTNSARAISAP----STPLLLPTEDNEALPVKDFVKHVADLH 855

  Fly   641 ADGDIGFSREYEAIQNE------CISD-DLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQ 698
            |:..  ||:|:|.::..      |.:| .:..:.|.||:||.||||:||.|||||||.|.....:
Zfish   856 ANHK--FSKEFEILKESYEEIQGCTADMGITTDSSNHPDNKSKNRYINILAYDHSRVKLSQNSDK 918

  Fly   699 K-KNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMY 762
            . |..||||||::||:.:..|:|..||||..:.:.||||||||.|.:|||||||||:||||||.|
Zfish   919 DGKTGDYINANYVDGFNQPKAYIAAQGPLKGSLEDFWRMIWEQNVGVIVMITNLVEKGRRKCDQY 983

  Fly   763 WPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKK--KKQCNTEKLVYQYHYTNWPDHGTP 825
            ||.:..|.||...|.|.....::.||:||..::::::||  :|..:.|:.|..:|||.|||.|.|
Zfish   984 WPLENQEDYGCFLVTLKSSRTLAYYTLRTFTLRNVQIKKGSQKGRSQERTVLHFHYTQWPDMGVP 1048

  Fly   826 DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRA 890
            ::.||:|:|::.||.|..||.||:||||||||||||||||:|:|||||:::|.||:.|||:|||.
Zfish  1049 EYTLPLLSFIRTSSQARTAEMGPVVVHCSAGVGRTGTYIVIDSMLKQIKEENTVNIMGFLKHIRT 1113

  Fly   891 QRNFLVQTEEQYIFLHDALVEAIASGET----NLMAEQVEELKNCTPY----LEQQYKNIIQFQP 947
            |||:||||||||:|:||||||||.|.||    :|:...|..|....|.    ||:|:|.:.|...
Zfish  1114 QRNYLVQTEEQYVFIHDALVEAIRSKETLVSSSLIHTYVSGLLTPGPAGKTPLEKQFKLVSQSCA 1178

  Fly   948 KDIHIASAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPM 1011
            |.....:|:|:.|..|||.| :.|:|.|||.|:...|| .|||||||:|.||.:.|:|||||:|:
Zfish  1179 KQSDYTTALKESNVSKNRTACLMPVERSRVSLSAAAGE-SSDYINASYLLGFHQSREFIVTQNPL 1242

  Fly  1012 AHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ-----FWPDEATPIESDHYRVKF-----LNKTN 1066
            .:||.|||:|:||||.|.:|.|.  |..|.:.     :||.:..||..:.:.|.|     ||.:|
Zfish  1243 PNTIHDFWRMIWDHNTQIIVSLP--DTHNMSSEAECVYWPTKDEPISCETFTVSFRDEDSLNLSN 1305

  Fly  1067 KSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYG 1131
            :...:.:.|::::::|||.|.|.....|.||:..:|.|....::::....:..|.||::|.|..|
Zfish  1306 EEPVLVQHFILEALKDDYVLEVHQFQSPRWPDPDSPISNCFELINIIREESSRREGPVLIHDGCG 1370

  Fly  1132 GAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYN-ILSFL 1187
            |:.|..|||:.:|..:::..::.:|||.|::.:..||||:...|..:.:|. |||.:
Zfish  1371 GSSAGLFCALVTLVNQLDEENSVDVYQTARMINLMRPGVFNDVEQYQFLYKAILSLV 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020	24/96 (25%)
		fn3	343..430	CDD:394996	24/144 (17%)
		FN3	442..520	CDD:238020	17/81 (21%)
		R5-PTPc-1	704..907	CDD:350397	116/204 (57%)
		R5-PTP-2	989..1182	CDD:350398	71/202 (35%)
ptprz1b	XP_073803012.1	None