Protein Alignment Ptp99A and csw

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 857
• Identity: 180/857 - (21%)
• Similarity: 286/857 - (33%)
• Gaps: 319/857 - (37%)

  Fly   375 YHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTK----NEGEPSD---- 431
            |:..:|::|...   ..|:.|:.....:||.:        |.|...:.:|    .|.|.|.
  Fly    28 YNNNNINNNNNN---TLNNNNAYNNQRNFEYE--------RAIQAHYGSKGRRSEERERSGKFKA 81

  Fly   432 ------QIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDT--HR 488
                  ::...|:......||..|...|.:.:                 .|||....|.|.  :|
  Fly    82 SKGRKAKVTPPTETPEAQEPACKNCMTHDELA-----------------QIIKGVAKGADAQRNR 129

  Fly   489 DIRI-----------NASAKELETAMILQNLTTN---------------------SYYEVKVAAA 521
            |.|:           :|:|....:...|..||.:                     ::.....:.:
  Fly   130 DNRLQRRRRPLSAQPSAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGASCSNS 194

  Fly   522 TFSVINPKKIVL-----------GKFSESRIIQLQPNCEKLQPLLRQSHN---DYNLAVLVGIIF 572
            |.|::...::.|           ||.:|..|::...|...   |:|:|.:   |:.|:|...
  Fly   195 TLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSF---LVRESQSKPGDFVLSVRTD--- 253

  Fly   573 SCFGIILIIMAFFLWSRK--------CFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPV 629
                 ..:......|..|        .|......:|   |:...|.|:     ..|..:....|.
  Fly   254 -----DKVTHVMIRWQDKKYDVGGGESFGTLSELID---HYKRNPMVE-----TCGTVVHLRQPF 305

  Fly   630 NEFAKHVASLHADGDI----GFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRV 690
            |......|.::|..:.    ||..|:|::|.:. .|..........||:.||||.||..|||:||
  Fly   306 NATRITAAGINARVEQLVKGGFWEEFESLQQDS-RDTFSRNEGYKQENRLKNRYRNILPYDHTRV 369

  Fly   691 HLHPTPGQKKNLDYINANFID-------------------------------------------- 711
            .|..........:|||||:|.
  Fly   370 KLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNK 434

  Fly   712 ----------------------------------------------------------------- 711
                                                                             
  Fly   435 TCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGT 499

  Fly   712 -------------GYQKGHA-------------------------FIGTQGPL----PDTFDCFW 734
                         |..|.|:                         :|.|||.|    .:|...||
  Fly   500 PTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFW 564

  Fly   735 RMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG-VETYGVIQVKLIEEEVMSTYTVRTLQIKHLK 798
            .|:|::...:|||.|...|||:.||..|||.:| .|.:|..:::.:.|...|.||:|...:....
  Fly   565 NMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD 629

  Fly   799 LKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFV-----KKSSAANPAE-AGPIVVHCSAGV 857
            ...::       ::.||:..|||||.|..|..||||:     ::|..|...| .|||.||||||:
  Fly   630 QPARR-------IFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGI 687

  Fly   858 GRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN 919
            |||||:||:|.:|.||.:..:   :::...::.:|:||:.|||||.||.|::.|:...|   :|.
  Fly   688 GRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYI---QTL 749

  Fly   920 LMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIE---------GSR 975
            :..::.||.   :..:.::|.||              |....|.|.....|:.         .|:
  Fly   750 IARKRAEEQ---SLQVGREYTNI--------------KYTGEIGNDSQRSPLPPAISSISLVPSK 797

  Fly   976 VHLTPKPGEDGS 987
            ..|||...:.|:
  Fly   798 TPLTPTSADLGT 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020
		fn3	343..430	CDD:394996	12/58 (21%)
		FN3	442..520	CDD:238020	17/111 (15%)
		R5-PTPc-1	704..907	CDD:350397	86/363 (24%)
		R5-PTP-2	989..1182	CDD:350398
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	20/114 (18%)
		PTPc-N11_6	352..748	CDD:350392	101/405 (25%)