DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and mop

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster

Alignment Length:	1040	Identity:	193/1040 - (18%)
Similarity:	314/1040 - (30%)	Gaps:	350/1040 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 ERPLLISFTSRSVNLSWAHSQHPRNAPVT---HFII-------ETREGEDGIWEQLARIYTKTNA 198
            ::||.::.:...|::|     :|...|.|   .|::       :|..|..|      :.|.:.||
  Fly   889 QQPLYVATSGNPVSVS-----NPSELPSTLQAPFVVNPMSNPYQTAAGYSG------QAYQQVNA 942

  Fly   199 TSYQVTGLTPFTVYSFRLLAVNKLGISP------------------------------------- 226
            .:.|||..|..:..|....|...||.:|
  Fly   943 QAQQVTYPTAPSGSSTGQSAQQPLGYAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSGYAQQLT 1007

  Fly   227 PSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWKAPPPDTILGEFLGY-----RITYRPRDR 286
            |.:::.|  :..:||. ...|:.|.|..||......:...|.|......||     :.|..|:.:
  Fly  1008 PQQQTGY--SQSQAPQ-LQAPSYAQNQQSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGYPQSQ 1069

  Fly   287 DPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILV---------------- 335
            ........|.:..|.:    |.|....|.....|....:.|.|:...|.
  Fly  1070 TSQQQTTGYSQSQTPQ----QPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQAVQASPQPIPGQQ 1130

  Fly   336 ---------------MTD--------EGVPSKPQNLTILDVSANS----ITMSWHPPKNQNGAIA 373
                           .||        .||.|.|..:.:...:..|    :..|.||    :....
  Fly  1131 ATPPNAGQPLPYPQQYTDPNAAPAPAPGVSSVPSPVPVPTPAPTSSQAQVPTSPHP----SATYT 1191

  Fly   374 GY--HVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQR 436
            .|  |..:..:.|||    |...:|........|:..:....|: ..::...::.|....:||.|
  Fly  1192 SYSNHPGYSFNPQTG----KYEYSSGYQQDTSSLKGSQASQSYQ-FSQSGKQQSVGTTDSEIASR 1251

  Fly   437 TDVG-GPSAPAI----VNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASA 496
            ::.. |..:|.:    ||:......| .|.......:|:|...|:.......|.|       .:.
  Fly  1252 SNTATGFDSPIVSHTKVNMAAKDSTS-AIEGNESSNYYSTPYGYLGSVNPQQQPT-------PAP 1308

  Fly   497 KELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHND 561
            ....||.|......:|..|.:..::.....          |.:.:.:::|..|.|.|.:..
  Fly  1309 PSNSTASIYMQSGASSTAETQTTSSGVPYA----------SSAALTKVEPKPEALPPKVTS---- 1359

  Fly   562 YNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPN---APQVDWEVPVKIGDEI 623
             |:.:|..:...|...:                      .||..|.   .||| ...|.....::
  Fly  1360 -NVDLLSDLDIDCSVAV----------------------PPPMLPQPVLQPQV-VATPTPPASQV 1400

  Fly   624 RAAVPVNEFAKHVASLHAD-------------------------------GDIGFSREYE----- 652
            ...|.|...|:|.|...|:                               .|:.....::
  Fly  1401 SVPVKVESVAEHAAPATAEIPVAATEGTAQTPVTIPSGPKCASLDNLSNCSDLSSLENFDWDSVS 1465

  Fly   653 -----------------------AIQNECISDDLPCEHSQ-------------HPE--------- 672
                                   |.|:|..:|:...::.|             |.:
  Fly  1466 VTHSVSEKQTKASATANGHSSSFAFQSETFTDEKTTKYFQKEVESYEKLLENLHVKMLNGKTQLG 1530

  Fly   673 ----------------NKR----------KNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFID 711
                            |||          |||.|:...|||:||.|     .|:..|||||.::.
  Fly  1531 AKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL-----DKQTDDYINAAYMK 1590

  Fly   712 GYQKG-HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQ 775
            ....| ..||..|.|.|:|.:.||.|||.::...:|.:    .......|.|||:
  Fly  1591 NLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQ---------- 1641

  Fly   776 VKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYH------------YTNWPDHGTPDHP 828
             .|.:......|||..|:::.|     ..|:..:|....|            ...| ..|.|...
  Fly  1642 -ALDQPTHYDDYTVTCLKVQQL-----SHCSEYQLKLSMHGADAVLDLSLLQLKQW-TKGAPAQL 1699

  Fly   829 LPVLNFV-----KKSSAANPAEAGPIVVHCSAGVGRT-----GTYIVLDAMLKQIQQKNIVNVFG 883
            |.|....     ::..||| |...|::::|..|..|:     |...::....||....|.::|:.
  Fly  1700 LGVAENALETHRQRCKAAN-APQSPLIMNCLTGSERSELVAIGVCAIIATQNKQPILLNTIDVWS 1763

  Fly   884 FLRHIRAQR------NFLVQTEEQYIF--LHDAL-VEAIASGETNLMAEQV---EELKNCTPYLE 936
               .|.|||      :.:::...|.:.  .|:.| ...|.:.....||.||   |:.:|..|..|
  Fly  1764 ---RICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRGIMTSYQMKMAPQVTAKEQQENKDPLNE 1825

Fly 937 936
Fly 1826 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	25/138 (18%)
		fn3	249..331	CDD:278470	18/86 (21%)
		FN3	342..437	CDD:238020	18/100 (18%)
		FN3	442..520	CDD:238020	15/81 (19%)
		PTPc	646..911	CDD:214550	76/372 (20%)
		PTPc	676..911	CDD:238006	67/266 (25%)
		PTPc	935..1186	CDD:214550	1/2 (50%)
		PTPc	963..1169	CDD:238006
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446	67/383 (17%)
		Y_phosphatase	1558..1788	CDD:278528	65/259 (25%)
		PTPc	1559..1745	CDD:238006	56/212 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810