Protein Alignment Ptp99A and Ptp69D

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1489
• Identity: 361/1489 - (24%)
• Similarity: 577/1489 - (38%)
• Gaps: 442/1489 - (29%)

  Fly    50 AEAGKNVTIPCPGVNEHSLVDTLVWKTASTTI-----------------------------AQFA 85
            ||.||||::.|...||     .:.||..:.||                             .::.
  Fly    35 AEIGKNVSLECASENE-----AVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYK 94

  Fly    86 NRIPLL-------------------HSPRIQL--------------------------------- 98
            |.:.||                   ||...|:
  Fly    95 NVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMY 159

  Fly    99 ------------------------------LSD---NFGLQFSPSLASDTSEYICLVND---RHI 127
                                          |:|   ||.|:|:.....:...|.|.|.|   ..|
  Fly   160 PQNETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEI 224

  Fly   128 PEAIVDLLVQDVPDPPERPLLISFT----SRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQ 188
            ....:.|.|.:||.     :.|.|.    :..:.|:|  :.:..|.|:..|.|..:|.....: .
  Fly   225 TSKEITLFVMEVPQ-----VSIDFAKAVGANKIYLNW--TVNDGNDPIQKFFITLQEAGTPTF-T 281

  Fly   189 LARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNT 253
            ..:.:...:.|||.:....|.|.|..|::..|.:|...|::....|.||...|...|...|..:|
  Fly   282 YHKDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGST 346

  Fly   254 SSTSVYISWKAPPPDTILGEFLG-YRITYRPRDRDPNDTKE-IYIRDNTVESHEIQNLQTYTQYK 316
            :|| :.|.|..||||.|  :::. |.:........|...:| ||.:::....:....|:|.|.|:
  Fly   347 AST-ITIGWNPPPPDLI--DYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYE 408

  Fly   317 VTVQVFN--PEGLGP-ETTILVMTDEGVPSKPQNLTIL----DVS-ANSITMSWHPPKNQNGAIA 373
            ..|:..:  .:..|| ...:...|.:||.:||.||:|.    :|: .|||.::|..||..||.:.
  Fly   409 FRVRACSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVV 473

  Fly   374 GYHVFHIHDN--------QTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTT-KNEGEP 429
            .| :.|:..|        ..|.:|.:......:||    .:::.|.|:|.|.|.|.|. |..|||
  Fly   474 SY-LIHLLGNPMSTVDREMWGPKIRRIDEPHHKTL----YESVSPNTNYTVTVSAITRHKKNGEP 533

  Fly   430 SDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRD----- 489
                |..:.:...|.|..:..|..|:.::..:             |::|..|. :.:.|:
  Fly   534 ----ATGSCLMPVSTPDAIGRTMWSKVNLDSK-------------YVLKLYLP-KISERNGPICC 580

  Fly   490 -----IRINASAKELETAMIL----------QNLTTNSYYEVKVAAATFSVINPKKIVLG---KF 536
                 :|||...|||.....|          .|:|.:|.|..::.::.:  ..| :|.||   :|
  Fly   581 YRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKY--FRP-EIFLGDEKRF 642

  Fly   537 SES------------------------RIIQLQP-----NCEKLQPLLRQSHN------------ 560
            ||:                        .||.:.|     |.:...|:|.:..|
  Fly   643 SENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHAL 707

  Fly   561 ----------------------------------------------------------------- 560
                                                                             
  Fly   708 KILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALM 772

  Fly   561 ------------------------DYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDD 601
                                    ||.|::.|.......|:||:.:.  ||   .||
  Fly   773 AYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIV--LW---VFH-------- 824

  Fly   602 PPHHPNAPQVDWEVPVKIGDEIRAAV-----------------------PVN--EFAKHVASLHA 641
              |.....::..|..:.:.|.:..|:                       |::  :......:.|.
  Fly   825 --HKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHK 887

  Fly   642 DGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYIN 706
            |.|.||.||||.:.|.  ..|...::|...||..||||.:|.|||.:||.|....| .:..||||
  Fly   888 DTDYGFLREYEMLPNR--FSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVING-LQTTDYIN 949

  Fly   707 ANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVET- 770
            |||:.||::...||..|||:..|.|.||||||||.:.||||:|||.|..:.||..|||:...:|
  Fly   950 ANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTK 1014

  Fly   771 -YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTE---KLVYQYHYTNWPDHGTPDHPLPV 831
             :|.|.||..:|.....|..|||.:.    |.|.....|   :.:.||||..|.|...|:||..:
  Fly  1015 QFGDILVKFAQERKTGDYIERTLNVS----KNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGI 1075

  Fly   832 LNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLV 896
            :.|:::.::....:.|||:||||||||||||.:.||::::|:::::.|:::..:..:|.||||||
  Fly  1076 IKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLV 1140

  Fly   897 QTEEQYIFLHDALVEAIASGETNL----MAEQVEELK------NCTPYLEQQYKNIIQFQPKDIH 951
            |:.:|||||:.||::....|.|::    ||..:|.||      .|.  ||.:::.::....:...
  Fly  1141 QSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCK--LEVEFEKLLATADEISK 1203

  Fly   952 IAS-AMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHT 1014
            ..| ...:.|::|||. .|.|.:.:||.|||.|..:.|.|||||::.|:.....||:.|.|:.:|
  Fly  1204 SCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENT 1268

  Fly  1015 IKDFWQMVWDHNAQTVVLLSSLDD--INFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVI 1077
            |.|||:|:.:.:..|:|::|.:.|  ....::|.|:  .::.||..||:::..:...|..|:|.:
  Fly  1269 IGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADD--EVQYDHILVKYVHSESCPYYTRREFYV 1331

  Fly  1078 QSIQDDYELTVKMLHCPSWPEMSN--PNSIYDFIVDVHERCNDYRN-------GPIVIVDRYGGA 1133
            .:.:.|..|.|.......||.:..  |......|..|.:..|.|:|       .|:.:....|..
  Fly  1332 TNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTD 1396

  Fly  1134 QACTFCA----ISSLAIE--MEYCSTAN----------------------VYQYAKLYH 1164
            ::..|.|    :..|.:|  ::.|:|..                      :..|:.|:|
  Fly  1397 RSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDLHH 1455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	21/99 (21%)
		FN3	243..337	CDD:238020	24/98 (24%)
		fn3	343..430	CDD:394996	31/100 (31%)
		FN3	442..520	CDD:238020	19/97 (20%)
		R5-PTPc-1	704..907	CDD:350397	91/207 (44%)
		R5-PTP-2	989..1182	CDD:350398	51/215 (24%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	16/83 (19%)
		Ig_3	134..216	CDD:464046	8/81 (10%)
		fn3	237..321	CDD:394996	19/91 (21%)
		FN3	<300..>524	CDD:442628	64/231 (28%)
		PTPc	892..1155	CDD:214550	117/269 (43%)
		PTPc	1186..1449	CDD:214550	64/266 (24%)