DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptp61F

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	123/455 - (27%)
Similarity:	201/455 - (44%)	Gaps:	76/455 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 EAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKG 716
            |....|..........|:...|:..|||.::..|||||:.|     ::.::||||||.:...:..
  Fly    39 ETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL-----KRGSVDYINANLVQLERAE 98

  Fly   717 HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD-GVE-----TYGVIQ 775
            ..:|.|||||.||...||.|:|||:...::|:..|:|:.:.||.:|||.: |.:     .:..:.
  Fly    99 RQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLT 163

  Fly   776 VKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVK--KS 838
            |:|:..|....:..|..::..|:.::.::      |.|:|||.|||.|.|..|...|.|::  :.
  Fly   164 VELVRLETYQNFVRRWFKLTDLETQQSRE------VMQFHYTTWPDFGIPSSPNAFLKFLQQVRD 222

  Fly   839 SAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYI 903
            |.....:.||.|||||||:||:||:.::|..|..|.:....||...|..:|:.|..|:||.:|..
  Fly   223 SGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLD 287

  Fly   904 FLHDALVEAI--------ASGETNLMAEQVE--ELKNCTPYLEQQYKNI-IQFQPKDIHIAS--- 954
            |.:.|::|.|        ...|..|::...|  .|....|.|..:.::: :...|....|.|
  Fly   288 FSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNSGGILSLNM 352

  Fly   955 AMKQVNSIKNRG------AI--FPIEGSRVH---------LTPKP----GEDGSDYINASWLHGF 998
            ...|.|..::.|      |:  |..:...:|         |.|.|    .:..||
  Fly   353 RAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFNDSDSD---------- 407

  Fly   999 RRLRDFIVTQHPMAHTIKD-FWQMVWDHNAQTV------VLLSSLDDINFAQFWPDEATPIESDH 1056
               .|:::.......|.:| .::.:.:|:|..|      ......||:|.....|  |.|::..|
  Fly   408 ---EDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKP--AVPVDEQH 467

Fly 1057 1056
Fly 468 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	88/266 (33%)
		PTPc	676..911	CDD:238006	84/242 (35%)
		PTPc	935..1186	CDD:214550	28/154 (18%)
		PTPc	963..1169	CDD:238006	22/122 (18%)
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	88/266 (33%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	84/243 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	1	0.900	-	-		E2759_KOG0789
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.810