DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Ptp52F

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster

Alignment Length:	974	Identity:	238/974 - (24%)
Similarity:	374/974 - (38%)	Gaps:	264/974 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQ-FANRIPLLH 92
            |....||..|    :|.:..||:...:    ||      .:..|....|:|.:.. :|.|....|
  Fly   552 LEMKNAGSEF----IDLIAFNADYNNS----CP------TIFALFTCNATTQVRNPYAERYVEGH 602

  Fly    93 SPRIQLLSDNFGLQFSPSLASDTSEYIC---LVNDRHIPEAIVDLLVQDV---PDPPERPLLISF 151
            |      ...|....||  .|..:.|:|   |.|.....|.:||..:...   |:.||..:|...
  Fly   603 S------KQGFNASLSP--LSPYATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQPESVMLEKS 659

  Fly   152 TSRSVNLSWAHSQHP--RNAPVTHF--IIETRE------GEDGIWEQLARIYTKTNATSYQVTGL 206
            |..|:..:|   |.|  .|.|:.::  .:...|      .:..|.||..:..||.: .|...|||
  Fly   660 TVSSLLFNW---QPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGD-PSVNFTGL 720

  Fly   207 TPFTVYSFRLLAVNKLGIS-----------PPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYI 260
            .|...|..::.|.|..|:.           |...:|   ||.....|..|:...|  ....:|.|
  Fly   721 APAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDS---VTQLTVLTQGPVNNNA--VYEANVTI 780

  Fly   261 SWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYI-----RDNTVESHEIQNLQTYTQ------ 314
            :||.|....  |:...:::.:       |.|:..:.     |...:::...|...:||:
  Fly   781 TWKVPCKSN--GDIEYFQLAF-------NGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQ 836

  Fly   315 --YKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHV 377
              |.|.|.|.|.:                         ::..::|:..||..|       ||...
  Fly   837 FDYTVEVSVKNRD-------------------------VEQLSSSVPGSWQSP-------AGLPT 869

  Fly   378 FHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGE---PSDQIAQRTDV 439
            .      ...|::|..|.:||     |..|.......|:.....|:.: |:   .:..|:|:...
  Fly   870 I------PSDELIKQMRANVE-----ETSNPTKTAIVRLPADIMTSAS-GDIKWMALMISQKNCA 922

  Fly   440 GGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMI 504
            |.|          |.:..::..|.:           ::..:.||.|...|..
  Fly   923 GVP----------HLKYDVSSDWPK-----------VLSYQEAGADGTGDCS------------- 953

  Fly   505 LQNLTTNSYYE---VKVAAATFSVINPKKIV----LGKFSESRIIQLQPNCEKLQPLLRQSHNDY 562
            |:..||...:.   |:.......|.:.::||    |.|.||.:    :..|.  .|||..:  ||
  Fly   954 LEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQ----KTYCN--GPLLPDT--DY 1010

  Fly   563 NLAV---------------------------LVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLD 600
            |:.|                           ||.:. ||..:..::....||.||
  Fly  1011 NVVVRLFTASGYSDAAVLNFKTKAAIKVTLILVSVC-SCLLLAFVLGLTVLWVRK---------- 1064

  Fly   601 DPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHAD--GDIGFSREYE-----AIQNEC 658
                     ::.|:.....|.|....   |..||:.|..:.:  .....:||::     |::...
  Fly  1065 ---------RLAWKRDSGQGIEDPFG---NVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSY 1117

  Fly   659 ISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQ 723
            .:.:|.|         .||||.:|..||.:||.|..   ..:..|||||:||||:.:...:|.||
  Fly  1118 SASELGC---------HKNRYADIFPYDKNRVILDI---DAEGSDYINASFIDGHTRKKEYIATQ 1170

  Fly   724 GPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGV--IQVKLIEEEVMST 786
            ||.|::...|||||.:..|.:||.:|...|....||..|:|      |.|  :.|.:..:||:..
  Fly  1171 GPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP------YNVRGLTVTIKSKEVLEL 1229

  Fly   787 YTVRTLQIKHLK--LKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPI 849
            |....|.:.|.|  ||:|        |..|::..|||||.|:.|:.::.||||..|.......||
  Fly  1230 YDRTELTVVHDKYGLKEK--------VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPI 1286

  Fly   850 VVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI 913
            |||||||||||||:|.||.::::::.::.:|:|..::.:|.||..:|||::||.||:....|.:
  Fly  1287 VVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	28/116 (24%)
		fn3	249..331	CDD:278470	18/94 (19%)
		FN3	342..437	CDD:238020	18/97 (19%)
		FN3	442..520	CDD:238020	11/80 (14%)
		PTPc	646..911	CDD:214550	100/273 (37%)
		PTPc	676..911	CDD:238006	95/238 (40%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	26/104 (25%)
		PTPc	1100..1345	CDD:214550	100/270 (37%)
		PTPc	1125..1348	CDD:238006	95/239 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010