Protein Alignment Ptp99A and Ptprk

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_063121937.1
• Gene: Ptprk / 360302
• RGDID: 619706
• Length: 1485
• Species: Rattus norvegicus
• Alignment Length: 1403
• Identity: 362/1403 - (25%)
• Similarity: 572/1403 - (40%)
• Gaps: 353/1403 - (25%)

  Fly    37 IFDVTNLDY-------------VKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRI 88
            |.|:..|.|             |:||  ||:|.|..|......: |...:|.....     ...|
  Rat   181 IDDIQVLSYPCDKSPHFLRLGDVEVN--AGQNATFQCIATGRDA-VHNKLWLQRRN-----GEDI 237

  Fly    89 PLLHSPRI--QLLSDNFGLQFSPSLASDTSEYICLVNDRHIP--EAIVDLLVQDVPDPPERP--- 146
            |:..:..|  :..:.:|.||  ....:|...|.|:.......  .....|:|::.|.|...|
  Rat   238 PVAQTKNINHRRFAASFRLQ--EVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLL 300

  Fly   147 ------LLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVTG 205
                  |||...:.|:         ..:.|:....:|.|. ..|.|.:...:    ||.:|::..
  Rat   301 GVGPTYLLIQLNANSI---------IGDGPIILKEVEYRM-TSGSWTETHAV----NAPTYKLWH 351

  Fly   206 LTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNT----------------- 253
            |.|.|.|..|:|      ::.|.          |..||.|.|.....|
  Rat   352 LDPDTEYEIRVL------LTRPG----------EGGTGLPGPPLITRTKCAEPMRTPKTLKIAEI 400

  Fly   254 SSTSVYISWKAPPPDTILGEFLGYRIT-------------YRPRDRDPNDTKEIYIRDNTVESHE 305
            .:..:.:.|          |.|||.||             :|..:....|..::   |.....|.
  Rat   401 QARRIAVDW----------ESLGYNITRCHTFNVTICYHYFRGHNESRADCLDM---DPKAPQHV 452

  Fly   306 IQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVS-ANSITMSWHPPKNQN 369
            :.:|..||...:.:.:.||||.......::.|||.||......::...| .|.|.::|..|...|
  Rat   453 VNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPN 517

  Fly   370 GAIAGYHVFH--IHDNQTGVEI------VKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNE 426
            |.|..|.|.:  |......|.:      |.|..||.    |....:|.|.|.|:..::|.|.|..
  Rat   518 GIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNST----HHVFMHLHPGTTYQFFIRASTVKGF 578

  Fly   427 GEPSDQIAQRTDVGGPSAP------AIVNLTCHSQESITIRWR------RPYEFYNTIDFYIIKT 479
            | |:..|...|::..||.|      |.:|.|.   .:||:..|      .|...|.     |:..
  Rat   579 G-PATAINVTTNISAPSLPDYEGVDASLNETA---TTITVLLRPAQAKGAPISAYQ-----IVVE 634

  Fly   480 RLAGQDTHRDIRINASAKELETAMILQNLTTNS---YYEVKV------AAATFSV---------- 525
            :|   ..||..|...:.:.....:..||..:..   |:..::      ..|.|:|
  Rat   635 QL---HPHRTKREAGTMECYRVPVTYQNSLSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFW 696

  Fly   526 ---INPKK---------IVLGKFSESRIIQLQPNC------EKLQPLLRQSHNDYNLA-----VL 567
               :.|:|         ..:.|.::::.:::....      |.:....:|:.....:|     ||
  Rat   697 NPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGVL 761

  Fly   568 VGIIFSCFGIILIIMAFFLWS--------RKCFHAAYYYL------------------------- 599
            |.|:.....|:::...:..|.        |:.:::..|||
  Rat   762 VFILLLLVVIVIVKKRYICWRRHICIRNIRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMD 826

  Fly   600 -----------DDP------------PHHPNAPQVDWEVPVKIGDE------------------- 622
                       :||            |..||.|.|...|.|.|.||
  Rat   827 RSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLC 891

  Fly   623 -----------IRAAVPVNEFAKHVASLHADGDIGFSREYEA-IQNECISDDLPCEHSQHPENKR 675
                       :..|:.|.:..:|:..:......||..|||: .:.:..|.|:    ::..:|:.
  Rat   892 EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDV----AKKDQNRA 952

  Fly   676 KNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFI------DGYQKGHAFIGTQGPLPDTFDCFW 734
            ||||.||.|||||||.|.|......: ||||||:|      ||||:...:|.||||:.:|...||
  Rat   953 KNRYGNIIAYDHSRVILQPVEDDPSS-DYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFW 1016

  Fly   735 RMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL 799
            ||:|:::.|.|||:|||||.||.||..||| |..|.||..:|..:|.|.::.|.|||..:
  Rat  1017 RMVWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTL----- 1075

  Fly   800 KKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYI 864
             :::..|..:.|.|:|:|.|||||.|.|...:|:|:::...:||..|||||||||||.||||.||
  Rat  1076 -ERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYI 1139

  Fly   865 VLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL--------- 920
            |:|.||...:::.:|:::..::.:|::|..:|||||||||:|||::||...|||.:
  Rat  1140 VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAY 1204

  Fly   921 --------------MAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGA-IFP 970
                          :.::.:.|.:.||.|          |.:|..||...:  |..|||.. :.|
  Rat  1205 FDMIRIDSQTNSSHLKDEFQTLNSVTPRL----------QAEDCSIACLPR--NHDKNRFMDMLP 1257

  Fly   971 IEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSS 1035
            .:.....|....|| .|:||||:.:..:|:...|||||:|:.:|:||||::|:|:...::|:|:.
  Rat  1258 PDRCLPFLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE 1321

  Fly  1036 LD-DINFAQFWPDEAT----PIESDHYRVKFLNKTNKSDYVSRDFVIQSI---QDDYELTVKMLH 1092
            :| .....|:||:|..    ||:     |:.::.:...|.::|.|.|.::   |:.| |.|:...
  Rat  1322 VDLSQGCPQYWPEEGMLRYGPIQ-----VECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQ 1380

  Fly  1093 CPSWPE----MSNPNSIYDFIVDV---HERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEY 1150
            ...|..    ..:..|....|:.|   .|.|.: ..|..:|....||.::..||||..:...::.
  Rat  1381 YLGWASHREVPGSKRSFLKLILQVEKWQEECEE-GEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR 1444

  Fly  1151 CSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNI-LSFL 1187
            .:..:|:...|...|.:|.:..:.|..|..|:: |.:|
  Rat  1445 QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	22/104 (21%)
		FN3	243..337	CDD:238020	22/123 (18%)
		fn3	343..430	CDD:394996	25/95 (26%)
		FN3	442..520	CDD:238020	19/98 (19%)
		R5-PTPc-1	704..907	CDD:350397	97/208 (47%)
		R5-PTP-2	989..1182	CDD:350398	56/207 (27%)
Ptprk	XP_063121937.1	None