DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and Lar

DIOPT Version :10

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1341 Identity:371/1341 - (27%)
Similarity:578/1341 - (43%) Gaps:328/1341 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 QDVPDPPERPLLISFTSRSVNLSWAHS-QHPRNAPVTHFIIETREGED---GIWEQLARIYTKTN 197
            :|||..|:........|.|:::||... :..||..:..:.|..:|..|   |...:..: :...:
  Fly   709 EDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFK-FDVVD 772

  Fly   198 ATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPI-PTTA----HNTSSTS 257
            ...:.||||.|.|.||.::.|:.:.|   ....|..||.  :.|.|.|: ||.:    ......|
  Fly   773 TLEFNVTGLQPDTKYSIQVAALTRKG---DGDRSAAIVV--KTPGGVPVRPTVSLKIMEREPIVS 832

  Fly   258 VYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQVF 322
            :.:.|:.|.  ...||..|||:.:..:|:   ..||..:....:......||:...:|:..|...
  Fly   833 IELEWERPA--QTYGELRGYRLRWGVKDQ---ALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGS 892

  Fly   323 NPEGLGPETTILVMTDEGVP-SKPQNLTILDVSANSITMSWHPP--KNQNGAIAGYHV-FHIH-D 382
            |..|:|.||..:..|.||.| ..|.|:||...:.:.:.::|.||  :::||.|..|.| ||.. |
  Fly   893 NHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKID 957

  Fly   383 NQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAI 447
            :..|.|.....|.:|.|       ||...|:|...|:|:|.:..|..||::...|:.....||..
  Fly   958 HGLGSERNMTLRKAVFT-------NLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMS 1015

  Fly   448 VNLTCHSQESITIRWRRP---------YEFYNT------IDFYIIKT------------------ 479
            :.....|:::..| |..|         |:.:.|      :|.:..||                  
  Fly  1016 LQAEATSEQTAEI-WWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQY 1079

  Fly   480 -------------RLAGQDTHR----DIRINASAKELET-AMILQ-----NLTTNSY------YE 515
                         ||:.:.|.|    |:.:|..|.::.| :|.|.     .||..:|      .:
  Fly  1080 AVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMK 1144

  Fly   516 VKVAAATFS---VINPKKIVLGKFSESRII-QLQP------------------------------ 546
            |.|.:..||   ::..::|:|..:.::..| :|.|                              
  Fly  1145 VFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMA 1209

  Fly   547 --------------NCEKLQPLLRQSHNDY----------------NL----------AVLVG-- 569
                          |.|::..:|.|:..:|                ||          .:|.|  
  Fly  1210 APQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRN 1274

  Fly   570 --------IIFSCFGIILIIMAFFLWSRKCFH------------------------AAYYYLDDP 602
                    .|.:.|....|...|.|.|...:|                        ..:.|...|
  Fly  1275 KPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSP 1339

  Fly   603 -----------------PHHP----------------NAPQVDWEV------------------- 615
                             ||.|                :.|::.|.|                   
  Fly  1340 FSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCV 1404

  Fly   616 ------PVKIGDE------IRAA-----------------------------VPVNEFAKHVASL 639
                  |.|..|:      :.||                             :|::|||.|:..|
  Fly  1405 VKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERL 1469

  Fly   640 HADGDIGFSREYEAIQ--NECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNL 702
            .::.:..||:|||:|:  .:...|:...||     ||.||||.|:||||||||.|....|...: 
  Fly  1470 KSNDNQKFSQEYESIEPGQQFTWDNSNLEH-----NKSKNRYANVTAYDHSRVQLPAVEGVVGS- 1528

  Fly   703 DYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG 767
            ||||||:.|||:|.:|::.|||||.:||..||||.||.:.|.|||:|.|.||.|.|||.|||..|
  Fly  1529 DYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRG 1593

  Fly   768 VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVL 832
            .||||.|.|.:.|.:.::||::||.|:      .::..|..:.:.|..:|.|||||.||||.|.|
  Fly  1594 TETYGQIFVTITETQELATYSIRTFQL------CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFL 1652

  Fly   833 NFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQ 897
            .|:::..|..|.|:||::|||||||||||.|||:|:||::::.:.|::::|.:..:|||||::||
  Fly  1653 QFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQ 1717

  Fly   898 TEEQYIFLHDALVEAIASGETNLMAEQ---------VEELKNCTPYLEQQYKNIIQFQPKDIHIA 953
            ||:||||:|||::|||..|.|.:.|..         :.|.......:|.::|.:...:.......
  Fly  1718 TEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFV 1782

  Fly   954 SAMKQVNSIKNRGA-IFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKD 1017
            :|....|..|||.. |.|.|.|||:|||..|.:||||:|||::.|:|....:|..|.|:....:|
  Fly  1783 TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAED 1847

  Fly  1018 FWQMVWDHNAQTVVLLSSLDDI---NFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQS 1079
            ||:|:|:||:..||:|:.|.::   ...|:||.|.: :...:|.|..:.:.|...|..|:|.:..
  Fly  1848 FWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERS-VRYQYYVVDPIAEYNMPQYKLREFKVTD 1911

  Fly  1080 IQDDYELTVKMLHCPSWPEMSNPNS---IYDFIVDVHERCNDY-RNGPIVIVDRYGGAQACTFCA 1140
            .:|....||:......|||...|.|   ..|||..||:....: ::|||.:....|..::..|..
  Fly  1912 ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFIT 1976

  Fly  1141 ISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIY 1181
            :|.:...|:|....:|:|..::..::||.:..:.:.....|
  Fly  1977 LSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCY 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020 24/99 (24%)
FN3 243..337 CDD:238020 24/98 (24%)
fn3 343..430 CDD:394996 28/90 (31%)
FN3 442..520 CDD:238020 26/139 (19%)
R5-PTPc-1 704..907 CDD:350397 103/202 (51%)
R5-PTP-2 989..1182 CDD:350398 56/200 (28%)
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 10/37 (27%)
FN3 712..810 CDD:238020 25/103 (24%)
FN3 832..898 CDD:214495 17/70 (24%)
FN3 <867..1269 CDD:442628 84/409 (21%)
fn3 914..998 CDD:394996 28/90 (31%)
R-PTPc-LAR-1 1498..1735 CDD:350401 129/248 (52%)
R-PTP-LAR-2 1784..2021 CDD:350402 74/235 (31%)
Blue background indicates that the domain is not in the aligned region.

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