DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and ptpn6

DIOPT Version :10

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:XP_009290703.1 Gene:ptpn6 / 335573 ZFINID:ZDB-GENE-030131-7513 Length:590 Species:Danio rerio


Alignment Length:608 Identity:160/608 - (26%)
Similarity:252/608 - (41%) Gaps:126/608 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   398 ETLIHFELQNLRPYTD------YRVIVK--AFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHS 454
            |.:.|..:||...|.|      :..:.:  .:.|.:.|...|:.....::..|       |.|  
Zfish    48 EIITHIRIQNTGDYYDLYGGEKFATLAELVEYYTGDHGTLQDKDGTVIELKYP-------LNC-- 103

  Fly   455 QESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVA 519
            .:..|.||...:              |:|.:..:.:|   ...|..|.::.::|:          
Zfish   104 SDPTTERWYHGH--------------LSGPNAEKLLR---ERNEPGTFLVRESLS---------- 141

  Fly   520 AATFSVINPKKIVLGKFSES------RIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGII 578
                   .|...||...::.      |:..::..|...:..:.......||..||. .|...|| 
Zfish   142 -------KPGDFVLSALTDDQTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVE-HFKRVGI- 197

  Fly   579 LIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADG 643
                       :.......||..|.:.......|.:..|...|:......::...|.:.:     
Zfish   198 -----------EELSGTMVYLKQPYYSTRLNAADIQSRVNQLDQTSEREKMDGADKKIKA----- 246

  Fly   644 DIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINAN 708
              ||..|::|:|..........:....||||.||||.||..:|.:||.|..........||||||
Zfish   247 --GFWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVVGSDYINAN 309

  Fly   709 F------IDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDG 767
            :      :...||  .:|..||.|..|.|.||:|:|::...:|||.|..||:||.||..|||...
Zfish   310 YVINKLMVTNPQK--TYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTE 372

  Fly   768 VET--YGVIQVKLIEEEVMSTYTVRTLQIK--HLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHP 828
            .|:  .|...|||:.|...:.|.||.:::.  |.....:|       ::.:.|.:|||||.|..|
Zfish   373 GESKEVGRYVVKLLSEMDAADYKVRVVELSAPHRNEAPRK-------IWHFQYLSWPDHGVPQEP 430

  Fly   829 LPVLNFVK---------KSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNV 881
            ..||:|:.         :|||       |||:|||||:|||||.:|:|.::..|..|.:   :::
Zfish   431 GGVLSFLDQVNRKQEELRSSA-------PIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDI 488

  Fly   882 FGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNI-IQF 945
            ...:..:|.||:.:||||.||.|::.|:::.|.|  |.:....:.|       .|.:|.|: ||.
Zfish   489 QKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYIES--TKVTRRAIME-------TETEYGNLSIQS 544

  Fly   946 Q-PKDIHIASAMKQVNSIKNRGA 967
            : ||....||:.|..:..:|.||
Zfish   545 KHPKASRKASSKKNEDVYENLGA 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
FN3 243..337 CDD:238020
fn3 343..430 CDD:394996 8/39 (21%)
FN3 442..520 CDD:238020 12/77 (16%)
R5-PTPc-1 704..907 CDD:350397 82/224 (37%)
R5-PTP-2 989..1182 CDD:350398
ptpn6XP_009290703.1 SH2_N-SH2_SHP_like 4..102 CDD:198203 10/60 (17%)
SH2_C-SH2_SHP_like 110..213 CDD:198185 23/149 (15%)
PTPc-N6 257..522 CDD:350454 99/280 (35%)
Blue background indicates that the domain is not in the aligned region.

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