DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and Ptpn7

DIOPT Version :9

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_001343311.1 Gene:Ptpn7 / 320139 MGIID:2156893 Length:359 Species:Mus musculus


Alignment Length:244 Identity:98/244 - (40%)
Similarity:144/244 - (59%) Gaps:19/244 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 PENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFW 734
            |.:..|:||..|.....|||.|.....|:.: ||||||:|.||. |...:|.||||:|:|...||
Mouse   117 PGHASKDRYKTILPNPQSRVCLGRAQSQEDS-DYINANYIRGYDGKEKVYIATQGPMPNTVADFW 180

  Fly   735 RMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL 799
            .|:|::.|::|||:|.|.| |:.||..|||.: .|.||..|:::.:.:....||||.|.|:|   
Mouse   181 EMVWQEDVSLIVMLTQLRE-GKEKCVHYWPTE-EEAYGPFQIRIQDMKEHPEYTVRQLTIQH--- 240

  Fly   800 KKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK----SSAANPAEAGPIVVHCSAGVGRT 860
              :::|.:.|.:.   ::.||||.||:...|:|..|.:    .:|||   :||||||||||:|||
Mouse   241 --QQECRSVKHIL---FSAWPDHQTPESAGPLLRLVAEVETPETAAN---SGPIVVHCSAGIGRT 297

  Fly   861 GTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDAL 909
            |.:|......:|::.:..|::.|.:..:|..|..::||.|||.|||..|
Mouse   298 GCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
fn3 249..331 CDD:278470
FN3 342..437 CDD:238020
FN3 442..520 CDD:238020
PTPc 646..911 CDD:214550 98/244 (40%)
PTPc 676..911 CDD:238006 97/239 (41%)
PTPc 935..1186 CDD:214550
PTPc 963..1169 CDD:238006
Ptpn7NP_001343311.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Interaction with MAP kinases. /evidence=ECO:0000250 38..51
PTPc-N7 105..349 CDD:350460 98/244 (40%)
Substrate binding. /evidence=ECO:0000250 290..296 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0789
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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