DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	113/302 - (37%)
Similarity:	173/302 - (57%)	Gaps:	33/302 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 PVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHL 692
            |:::..:.|..   .|..|..:||..|:|.  :.:....|::...|..||||.::..||||||.|
  Fly   517 PIDQIVQMVKQ---RGRHGLIKEYADIRNR--APEGTFLHARMRANLTKNRYTDVLCYDHSRVVL 576

  Fly   693 HPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRR 757
            ....|.:.: |||||||:|||::.:|:|.||||||.|...||||||||...:|||.|.::||||.
  Fly   577 AHEDGDEPS-DYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRV 640

  Fly   758 KCDMYW--PKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKL--VYQYHYTN 818
            ||..||  .::....:|...|:.|..|....|.|.:|:::::|        |:::  |..:.:|:
  Fly   641 KCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIK--------TDEIRNVSHWQFTS 697

  Fly   819 WPDHGTPDHPLPVLNFVKK--------------SSAANPAEAGPIVVHCSAGVGRTGTYIVLDAM 869
            |||:|.|...:.:|||::|              :.|.:| ...|||||||||:|||||:|.||..
  Fly   698 WPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHP-RGPPIVVHCSAGIGRTGTFITLDIC 761

  Fly   870 LKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE 911
            :.:::.....::.|.:..||:||.:.:|..:||:|.|.||:|
  Fly   762 ISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCHLALIE 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	109/282 (39%)
		PTPc	676..911	CDD:238006	102/252 (40%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	103/255 (40%)
		PTPc	559..803	CDD:238006	102/253 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I1235
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010