Protein Alignment Ptp99A and Ptprb

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001416429.1
• Gene: Ptprb / 314843
• RGDID: 1305922
• Length: 2238
• Species: Rattus norvegicus
• Alignment Length: 1113
• Identity: 270/1113 - (24%)
• Similarity: 437/1113 - (39%)
• Gaps: 317/1113 - (28%)

  Fly    28 TLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRIPLLH 92
            |:||:..|.:.|         ||.:..::|:.              |:.|    ...|.|..:|
  Rat  1232 TVPASVHGVVAD---------NAYSSNSLTVS--------------WQKA----LGMAERYDIL- 1268

  Fly    93 SPRIQLLSDNFGLQFSPSLASDTSE--------------------YICLVN-----------DRH 126
                 |||:| |:     |.|:|||                    .|..|:           .|.
  Rat  1269 -----LLSEN-GV-----LLSNTSEPATVKQHKFEDLTPGKKYKMQILTVSGGLFSKEVETEGRT 1322

  Fly   127 IPEAIVDLLVQDVPDPPERPLLISFTSRSVNLSW------------------------------- 160
            :|.|:.:|   .:.:...|.|..|:|:....|||
  Rat  1323 VPAAVTNL---RITENSSRHLSFSWTASEGELSWYNIFLYNPDKTLQERAQVDPLVQSFSFQNLL 1384

  Fly   161 ----------AHSQHPRN----------APVTHFIIETREGEDGIW----------EQLARIYTK 195
                      .||....|          |.|.|.....|...|.:|          :....|...
  Rat  1385 QGRMYKMVIVTHSGELSNESFIFGRTVPAAVNHLKGSNRNMTDSLWFSWSPASGDFDFYELILYN 1449

  Fly   196 TNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVT----LREAPTGK----PIPTTA-- 250
            .|.|..:.......|.:.|:       |:.|..|.:.|:||    |....||:    |.|.:.
  Rat  1450 PNGTKKENWREKDVTEWRFQ-------GLIPGRKYTLYVVTHSGDLSNKVTGEGRTAPSPPSLLS 1507

  Fly   251 -HNTSSTSVYISWKAPPPDTILGEFLGYRITYRPRDR----DPNDTKEIYIRDNTVESHEIQNLQ 310
             .:.::||:.|:||.||..|   ::..:.:.:.|.|.    :|..:|:       .|...:..|:
  Rat  1508 FADVANTSLAITWKGPPDWT---DYNDFELQWLPGDALTVFNPYSSKK-------SEGRIVNGLR 1562

  Fly   311 TYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGY 375
            ....|:.:|:..:.:.....:..:..:....|.|.|||.....::.:|..||.||.:.      :
  Rat  1563 PGRSYQFSVKTVSGDSWKTYSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSD------F 1621

  Fly   376 HVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRT--- 437
            ..:.|...:...:.::.||...:......:..|.|:..|.|.:|   .::.|..|:.:...|
  Rat  1622 DGYSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHRRYLVSIK---VQSAGVTSEVVEDSTITM 1683

  Fly   438 -DVGGPSAPAI-VN----LTCHSQESITIR--WRRPYEFYNT---IDFYIIKTRLAGQ------- 484
             |...|..|.| ||    |...|..:.|:.  |     |.:|   :.::.:..|.|..
  Rat  1684 IDRPPPPPPHIRVNEKDVLISKSSINFTVNCSW-----FSDTNGAVKYFAVVVREADSMDELRPE 1743

  Fly   485 -----DTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKK------IVLGKFSE 538
                 .::.:.|.|||.:..:|          :|:..|.|.:.    :|.:      |.||...:
  Rat  1744 QQHPLPSYLEYRHNASIRVYQT----------NYFASKCAESP----DPDRSSKSFNIKLGGEMD 1794

  Fly   539 SRIIQLQPNCEKL--QPLLRQSHNDYNLAV----------------------------------L 567
            |...:..|:.:|.  .||  :.|..|.:::                                  |
  Rat  1795 SLGGKCDPSQQKFCDGPL--KPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPITTESEPL 1857

  Fly   568 VGII------FSCFGIILIIMAFFLWSRKCFH------AAYYYLDDPP--HHPNAPQVDWEVPVK 618
            .|:|      ....|:::.::|||:..:|..|      |......|.|  .|.|..|       |
  Rat  1858 FGVIEGVSAGLFLIGMLVALVAFFICRQKASHSRERSSARLSIRRDRPLSVHLNLGQ-------K 1915

  Fly   619 IGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNIT 683
            ...:....:.:|:|..|...|.||.:...|:|||.:::  :.....|:.:..|||:.||||.||.
  Rat  1916 GNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKD--VGRSQSCDIALLPENRGKNRYNNIL 1978

  Fly   684 AYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMI 748
            .||.|||.|........: |||||::|.|......:|.||||||.|.|.||:|.|||.|..|||:
  Rat  1979 PYDASRVKLCNVDDDPCS-DYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMV 2042

  Fly   749 TNLVERGRRKCDMYWPKDGVET-YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVY 812
            |..||:||.|||.|||.|.... ||.:.::::.|.|:..:|:|     ..|:..::|.:..:|:.
  Rat  2043 TQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTIR-----EFKICSEEQLDAHRLLR 2102

  Fly   813 QYHYTNWPDHGTPDHPLPVLNFVK--KSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQ 875
            .:|||.|||||.|:....::.||:  :........|||.|||||||||||||::.||.:|:|:..
  Rat  2103 HFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDS 2167

  Fly   876 KNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQ-- 938
            |:.|:::|.:..:|..|..:||||.||::||..:.:.:          :..:|:|     ||:
  Rat  2168 KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL----------RARKLRN-----EQENP 2217

  Fly   939 ----YKNI 942
                |:|:
  Rat  2218 LFPIYENV 2225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	25/156 (16%)
		FN3	243..337	CDD:238020	19/104 (18%)
		fn3	343..430	CDD:394996	18/86 (21%)
		FN3	442..520	CDD:238020	20/99 (20%)
		R5-PTPc-1	704..907	CDD:350397	89/205 (43%)
		R5-PTP-2	989..1182	CDD:350398
Ptprb	NP_001416429.1	None