DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Ptp4E

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster

Alignment Length:	1019	Identity:	255/1019 - (25%)
Similarity:	407/1019 - (39%)	Gaps:	205/1019 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NVTI-PCPGVNEHSLVD----TLVWKTASTTIAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASD 114
            |||: |.|..|...|||    ||.|                   ||.....|.:.|::.|:...|
  Fly   704 NVTMPPQPVSNVVPLVDSRNLTLEW-------------------PRPDGHVDFYTLKWWPTDEED 749

  Fly   115 TSEYICLVNDRHIPEAIVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTH---FII 176
            ..|:..:.....:....|.:.::|:....:....:..:|..:.....|.. .|..|:..   ||.
  Fly   750 RVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLS-TRTMPLIQSDVFIA 813

  Fly   177 ET--REGEDGIWEQLARIYTKTNATSYQVTGLTPFTVYSFRL----------LA---VNKLGISP 226
            ..  .:|:|   |.:...||.|.|.|      |.|.:|.|.:          ||   ..||..|.
  Fly   814 NAGHEQGQD---ETITLSYTPTPADS------TRFDIYRFSMGDPTIKDKEKLANDTERKLSFSG 869

  Fly   227 PSKESYYIVTLREAPTG------------KPIPTT---AHNTSSTSVYISWKAPPPDTILGEFLG 276
            .:....|.||:.....|            .|:|.:   |...::..:.:.|.||     .||:..
  Fly   870 LTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAP-----AGEYTD 929

  Fly   277 YRITYRPRDRDPNDTKEIYIRDNTVESHEI--QNLQTYTQYKVTVQVFNPEGLGPE-----TTIL 334
            :.:.|...|.:...     :..|..::.||  |.|:.|..|..||.|.:....|.:     .:.|
  Fly   930 FELQYLSADEEAPQ-----LLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTL 989

  Fly   335 VMTDEGVPSKPQNLTI----------LDVSANSITMSWH-PPKNQNGAIAGYHV-FHIHDNQTGV 387
            :.:...:.:..|.||.          .||....:|..|. .|..|:|.|..:.: ....|:...|
  Fly   990 MRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADV 1054

  Fly   388 EIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGP-SAPAIVNL- 450
            ...:...|:.:.    ::..|.|...|...::|.:....|...:.|.....:..| ..|::..|
  Fly  1055 SSYEFPVNATQG----KIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLE 1115

  Fly   451 TCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYE 515
            ...:..:|.|.:|:.| |.|........|.:..:|..:    |||..|:.:...:|..|....|:
  Fly  1116 VSRTSSTIEISFRQGY-FSNAHGMVRSYTIIIAEDVGK----NASGLEMPSWQDVQAYTVWLPYQ 1175

  Fly   516 VKVAAATFSVINPKKIVLGKFSESRIIQLQ--------PNCEKLQ------PLLRQSHNDYNL-- 564
                     .|.|....|.. :.||...|:        .||:|.|      ||  ::...|.:
  Fly  1176 ---------AIEPYNPFLTS-NGSRKSSLEAEHFTIGTANCDKHQAGYCNGPL--RAGTTYRIKI 1228

  Fly   565 ------------------------AVLVGIIFSCFGIILIIMAFFLWSRKC-----------FHA 594
                                    .|:|....|...::.:::.......:|           ...
  Fly  1229 RAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQD 1293

  Fly   595 AYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECI 659
            ....|.:....||.|                 |.|.:|::|...:.||.|..||.|:|.:::  :
  Fly  1294 ELAALPEGYITPNRP-----------------VHVKDFSEHYRIMSADSDFRFSEEFEELKH--V 1339

  Fly   660 SDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQG 724
            ..|..|..:..|.|:.|||:.||..|||||..|.|......: ||||||::.|:.....||.|||
  Fly  1340 GRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGS-DYINANYMPGHNSPREFIVTQG 1403

  Fly   725 PLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVET-YGVIQVKLIEEEVMSTYT 788
            ||..|.:.||||.||.....|||:|...|:||.|||.|||.|.|.. ||.|:|:||.:.....::
  Fly  1404 PLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWS 1468

  Fly   789 VRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHC 853
            :....:       .:.|.: :::..:|:|.|||.|.|:.|..::.||:........:..||:|||
  Fly  1469 ISEFMV-------SRNCES-RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHC 1525

  Fly   854 SAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGET 918
            ||||||:||:|.||.:|:.|.:.:.|::||.:..:|.:|.|:||||:||:.:|..|: |:..|:.
  Fly  1526 SAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKE 1589

  Fly   919 NLMAEQVEELKN-----CTPYLEQQYKNIIQFQPKDIHIASAMK 957
            :|:|:.:|...|     ...|||:|.:..:...|....:|.|.|
  Fly  1590 HLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEK 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	24/113 (21%)
		fn3	249..331	CDD:278470	19/91 (21%)
		FN3	342..437	CDD:238020	20/106 (19%)
		FN3	442..520	CDD:238020	18/79 (23%)
		PTPc	646..911	CDD:214550	105/265 (40%)
		PTPc	676..911	CDD:238006	97/235 (41%)
		PTPc	935..1186	CDD:214550	7/23 (30%)
		PTPc	963..1169	CDD:238006
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470
		FN3	548..611	CDD:238020
		FN3	620..706	CDD:238020	1/1 (100%)
		fn3	708..796	CDD:278470	19/106 (18%)
		fn3	824..886	CDD:278470	17/67 (25%)
		fn3	902..978	CDD:278470	19/85 (22%)
		fn3	1013..1092	CDD:278470	16/82 (20%)
		UP_III_II	1106..>1248	CDD:297589	30/158 (19%)
		PTPc	1329..1582	CDD:214550	104/263 (40%)
		PTPc	1355..1582	CDD:238006	96/235 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I1235
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010