DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Igfn1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_008767806.2	Gene:	Igfn1 / 304823	RGDID:	1565384	Length:	2699	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	122/468 - (26%)
Similarity:	194/468 - (41%)	Gaps:	68/468 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GFVLLLILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIP---CPGVNEHSLVDTLVWKTAS-- 78
            |....|||..:..|||||...|..    :.::||...|..|   .|.|.| .|.:.||:|...
  Rat  1955 GLTHRLILTHVEGTQAGRYTFVAG----RQHSEASLTVQDPPTIAPDVTE-KLREPLVFKAGKPV 2014

  Fly    79 TTIAQFANRIPLLHSPR-------------IQL-LSDNFGLQFSPSLA-SDTSEY-ICLVNDRHI 127
            |....|.:|:|:..:.|             ||| |.|.:.....||:. .|:..| :.|.::...
  Rat  2015 TVKIPFQSRLPVQAAWRKDGKEVAGSNHKGIQLALGDGYTRLCLPSVCRKDSGRYSVRLKSEGGC 2079

  Fly   128 PEAIVDLLVQDVPDPPERPLLISFTSRS-VNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLAR 191
            .||...|.|.|.|.||:.||.:....|: |.|.|...:......:.|:::|.|:.....|.::..
  Rat  2080 VEAEFTLQVIDKPRPPQGPLEVQACHRAGVCLRWLPPRDDGGQVIQHYVVERRQAGRSTWLKVGE 2144

  Fly   192 IYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSST 256
              ...::||:....:.....|:||:.||...| :..:.||..::...||..|.|......:.||.
  Rat  2145 --PPPDSTSFTDVIVEQGRKYAFRVRAVTSEG-AGDALESEEVLIAPEALPGPPSAPAILSASSQ 2206

  Fly   257 SVYISWKAP--PPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVES--HEIQNLQTYTQYK- 316
            |:.::|.||  |..|   ..|||.:..|.:    ..:..:.:.:..|..  :.:.:|:...||:
  Rat  2207 SITLTWGAPQGPGST---HILGYLVEKRKK----GSSTWMAVNEQPVSERRYTVVDLRQGCQYEF 2264

  Fly   317 --VTVQVFNPEGLGPETTILVMTDEGVPSKP-QNLTILDVSANSITMSWHPPKNQNGAIAGYHVF 378
              :.|.:..|...||.:..:...|...|..| ::|.:.|.|..|||:||..|..|:...|..::
  Rat  2265 RVMAVTLSGPGEPGPPSDAVFARDPMRPPGPVRDLQVTDTSDTSITVSWMVPDAQDADEAQGYI- 2328

  Fly   379 HIHDNQTGVEIVKNSRN--------SVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQ 435
                    ||:..:..:        :|...| |..:.|||...|.|.|   |..|:|..|..::.
  Rat  2329 --------VELCGSDSHQWSPCHMGTVPGTI-FTAKGLRPQEGYFVRV---TAVNDGGRSPAMSL 2381

  Fly   436 RTDVGGPSAPAIV 448
            .|.|  .:.||.|
  Rat  2382 DTLV--HAMPATV 2392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	23/96 (24%)
		fn3	249..331	CDD:278470	20/88 (23%)
		FN3	342..437	CDD:238020	28/103 (27%)
		FN3	442..520	CDD:238020	3/7 (43%)
		PTPc	646..911	CDD:214550
		PTPc	676..911	CDD:238006
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Igfn1	XP_008767806.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900