DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn18

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_038939136.1	Gene:	Ptpn18 / 301333	RGDID:	1311586	Length:	459	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	108/338 - (31%)
Similarity:	171/338 - (50%)	Gaps:	34/338 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 HADGDIGFSREYEAIQNECIS--DDLPC--EHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKK 700
            |.:|.| .:||:..|:...::  .:..|  :......|.:||||.::..||.:||.|.... ::.
  Rat    20 HREGAI-LAREFSDIKARSVAWKTEGVCSTKAGSQQGNSKKNRYKDVVPYDETRVILSLLQ-EEG 82

  Fly   701 NLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK 765
            :.||||||||.|.....|:|.||||||.|...|||::||..|.:|:|.....|.|||||:.||.:
  Rat    83 HGDYINANFIRGTDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAQ 147

  Fly   766 DGVETY-GVIQVKLIEEEVMST-YTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHP 828
            :..... |...:.|.:|..::. .|:||||:...|:.|.::  ..:.|:|..|.:|||||.|...
  Rat   148 EREPLQAGPFCITLTKETALTADITLRTLQVTFQKVPKGQK--ESRPVHQLQYMSWPDHGVPSSS 210

  Fly   829 LPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI---VNVFGFLRHIRA 890
            ..:|..|:::........||:.||||||.||||....:|.:.:.:..:.|   .::|..:..:|.
  Rat   211 DHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRK 275

  Fly   891 QRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASA 955
            ||...|||||||.||:..:.:..:           ..|:|.:|.    |:|:.:      :.|..
  Rat   276 QRPAAVQTEEQYRFLYHTVAQLFS-----------RTLQNNSPL----YQNLKE------NRAPI 319

  Fly   956 MKQVNSIKNRGAI 968
            .|..:|::...|:
  Rat   320 CKDSSSLRTSSAL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	96/273 (35%)
		PTPc	676..911	CDD:238006	91/239 (38%)
		PTPc	935..1186	CDD:214550	6/34 (18%)
		PTPc	963..1169	CDD:238006	1/6 (17%)
Ptpn18	XP_038939136.1	PTP_DSP_cys	27..298	CDD:421693	96/273 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810