DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Ptpn22

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001099930.1	Gene:	Ptpn22 / 295338	RGDID:	1307992	Length:	804	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	190/801 - (23%)
Similarity:	284/801 - (35%)	Gaps:	256/801 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 EFAKHVASLHADGDIGFSREYEAIQNECISDDL-PCEHSQHPENKRKNRYLNITAYDHSRVHLHP 694
            |||.....|...     |.:|:|       |.: |...:|.|:|.:||||.:|..||||.|.|..
  Rat    23 EFANEFLKLKRQ-----STKYKA-------DKIYPTTVAQRPKNIKKNRYKDILPYDHSLVELSL 75

  Fly   695 TPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKC 759
            ....:.: .||||:||.|.....|:|.|||||..|...|||||||.||.:|||.....|.|::||
  Rat    76 LTSDEDS-SYINASFIKGVYGPRAYIATQGPLSTTLLDFWRMIWEYRVLVIVMACMEFEMGKKKC 139

  Fly   760 DMYWPKDGVET---YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTE-KLVYQYHYTNWP 820
            :.||.:.| ||   :|...:....|:..|.|.:|||:.|.         |:| ::|||:||.|||
  Rat   140 ERYWAEPG-ETQLQFGPFSISCETEKKKSDYKIRTLKAKF---------NSETRIVYQFHYKNWP 194

  Fly   821 DHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD---AMLKQ-IQQKNIVNV 881
            ||..|....|:|..:.........:..|:.:|||||.||||....:|   .:||. |..||. :|
  Rat   195 DHDVPSSIDPILQLIWDMRCYQEDDCVPLCIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNF-SV 258

  Fly   882 FGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQ 946
            |..::.:|.||..||||:|||..::.|::|.
  Rat   259 FNLIQEMRTQRPSLVQTQEQYELVYSAVLEL---------------------------------- 289

  Fly   947 PKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPM 1011
                                                               |:|..|.|..
  Rat   290 ---------------------------------------------------FKRHVDIISD---- 299

  Fly  1012 AHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEATPIESDHYRV----------KFLNKTN 1066
                        :|..:.:....|:         |::...||:|.|.:          |..|:.:
  Rat   300 ------------NHREREIQAECSI---------PEQKLTIEADSYPLDFPKNAVRDAKMTNQQS 343

  Fly  1067 KSDYVSRDFVIQS-------IQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPI 1124
            |....:....:.|       |....||   :||..|.|...        .::::..||.
  Rat   344 KQGAEAESTEVSSFGLRTSKISAKEEL---VLHSKSSPSFD--------CLELNCECNK------ 391

  Fly  1125 VIVDRYGGAQAC--------TFCAISSLAIEMEYCSTANVYQYAKLYHN-KRPGVWTSSEDIRVI 1180
            .::.|.|.|:|.        .:.::...:|....|.:|.....|...|| |.|...|.|....:|
  Rat   392 AVITRNGQARASLVVGEPLQKYQSLDFGSILFGSCPSALPINTASRCHNSKGPVKRTKSTPFELI 456

  Fly  1181 Y----NILSFLPGN----LNLLKRTALRTEFEDVTTATPD------------------------- 1212
            .    |.|:...|:    ..||:...:..:.:.|..|:.:
  Rat   457 QQRKTNELAVEDGSSCLESQLLEHGLMELQAQKVAHASSEELNYSLPRACERPACDASCVPQDGP 521

  Fly  1213 --LYSKICSNVA--PLSSSSSTTPPPPS-----------------TPTPQPPQTIQLSSHSPSDL 1256
              |...:|.::|  |..|||    ||.|                 :|..|.|.:...||...:..
  Rat   522 GALREHLCMSLAEDPYFSSS----PPNSAGSKMSFDLPEKQDGATSPGAQLPASSAASSSYSNPR 582

  Fly  1257 SHQISSTVANAGSPATASAGATPTTPMT-PTVPPTIP-------TIPSLASQNSLTLTN----AN 1309
            ...:.||:.:...|.........|:..| ..:||.:|       .:...|.:.|.::|.    |.
  Rat   583 DSLMESTLTSFPPPINQETAIEATSARTDDEIPPPLPERTPESFIVAEAAGEPSPSITESLPLAG 647

  Fly  1310 FHTVTNNAADLMEHQQQQMLA 1330
            ...||.......|.|...::|
  Rat   648 KSGVTLECGGTSESQSHDLVA 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	107/273 (39%)
		PTPc	676..911	CDD:238006	99/242 (41%)
		PTPc	935..1186	CDD:214550	41/280 (15%)
		PTPc	963..1169	CDD:238006	35/231 (15%)
Ptpn22	NP_001099930.1	PTPc	24..288	CDD:214550	110/287 (38%)
Ptpn22	NP_001099930.1	PTPc	56..288	CDD:238006	99/243 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810