DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Egflam

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001276425.1	Gene:	Egflam / 268780	MGIID:	2146149	Length:	1017	Species:	Mus musculus

Alignment Length:	369	Identity:	86/369 - (23%)
Similarity:	136/369 - (36%)	Gaps:	93/369 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWKAPPPDTI 270
            ::.|::: |.|||.:    .||...|......:....|.|:.......:.|:..|.||.|....
Mouse     4 ISTFSLH-FLLLACS----LPPGAVSLRTALRKSGKVGPPLDIKLGALNCTAFSIQWKTPKRSG- 62

  Fly   271 LGEFLGYRITYRP-------RDRDPNDTKEIYIRDNTVESHE-IQNLQTYTQYKVTVQVFNPEGL 327
             ...:||.:.|..       |:|..|    :.:..:|:.:.| |.:|:..|:|:|:|..::..|.
Mouse    63 -SSIIGYTVFYSEVGSDKSLRERSHN----VPVGQDTLITEEVIGDLKPGTEYQVSVAAYSQTGK 122

  Fly   328 G----PETTILVMTDEGV-PSKPQNLTILDVSANSITMSWHPPKNQNGA-IAGYHVFHIHDNQTG 386
            |    |.....:..|..: |:.||...:|.||.:.:.:||.|.:|:..| |..|          .
Mouse   123 GRLSFPRHVTTLSQDSCLPPAAPQQPHVLVVSDSEVALSWRPGENEGSAPIQSY----------S 177

  Fly   387 VEIVKNSRNSVETLIHFELQ-------NLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSA 444
            ||.::...:...|:|...||       .|.|.|:|:..|||....
Mouse   178 VEFIRPDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAH-------------------- 222

  Fly   445 PAIVNLTCHSQESITIRWRRPYE----FYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMIL 505
                ..:..|..|.|:|...|.|    .|.  ..||....::..|       :.|..||:..:
Mouse   223 ----GFSPRSWPSNTVRTLGPGEAGSGHYG--PGYITNPGVSEDD-------DGSEDELDLDV-- 272

  Fly   506 QNLTTNSYYEVKVAAAT------FSVINPKKIVLGKFSESRIIQ 543
                  |:.|||...||      |||.:.|..|......||:.|
Mouse   273 ------SFEEVKPLPATKVGNKKFSVESKKTSVSNSVMGSRLAQ 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	8/29 (28%)
		fn3	249..331	CDD:278470	22/93 (24%)
		FN3	342..437	CDD:238020	26/102 (25%)
		FN3	442..520	CDD:238020	17/81 (21%)
		PTPc	646..911	CDD:214550
		PTPc	676..911	CDD:238006
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Egflam	NP_001276425.1	FN3	36..133	CDD:238020	24/102 (24%)
		FN3	142..236	CDD:238020	29/127 (23%)
		LamG	391..541	CDD:238058
		EGF_CA	560..602	CDD:238011
		LamG	618..765	CDD:238058
		EGF_CA	790..820	CDD:238011
		Laminin_G_2	868..993	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900