DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and PTPN22

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_057051.3	Gene:	PTPN22 / 26191	HGNCID:	9652	Length:	807	Species:	Homo sapiens

Alignment Length:	859	Identity:	208/859 - (24%)
Similarity:	317/859 - (36%)	Gaps:	237/859 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   614 EVPVKIGDEIRA-AVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKN 677
            |:..|..||.:: .:...|||.....|...     |.:|:|      ....|...::.|:|.:||
Human     5 EILQKFLDEAQSKKITKEEFANEFLKLKRQ-----STKYKA------DKTYPTTVAEKPKNIKKN 58

  Fly   678 RYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRV 742
            ||.:|..||:|||.|......:.: .|||||||.|.....|:|.|||||..|...|||||||..|
Human    59 RYKDILPYDYSRVELSLITSDEDS-SYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSV 122

  Fly   743 AIIVMITNLVERGRRKCDMYWPKDG---VETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQ 804
            .||||.....|.|::||:.||.:.|   :| :|...|....|:..|.|.:|||::|.
Human   123 LIIVMACMEYEMGKKKCERYWAEPGEMQLE-FGPFSVSCEAEKRKSDYIIRTLKVKF-------- 178

  Fly   805 CNTE-KLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD- 867
             |:| :.:||:||.|||||..|....|:|..:.........::.||.:|||||.||||....:|
Human   179 -NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDY 242

  Fly   868 --AMLKQ-IQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELK 929
              .:||. |..:|. :||..:|.:|.||..||||:|||..:::|::|        |...|::.::
Human   243 TWMLLKDGIIPENF-SVFSLIREMRTQRPSLVQTQEQYELVYNAVLE--------LFKRQMDVIR 298

  Fly   930 NCTPYLEQQYKNIIQFQPKDIH--------------IASAMKQVNSIKNRGAI-----FPIEGSR 975
            :.....|.|.|:.|   |:..|              ...|.|.:|..:.:..|     |....|.
Human   299 DKHSGTESQAKHCI---PEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360

  Fly   976 VH------LTPKPGEDGSDYINASWLHGFRRLRD---------FIVTQHPM-AHTIKDFWQMVWD 1024
            :.      |.|.......|::..:  :.|.:..|         |.:...|: .|...|...::::
Human   361 ISAKEELVLHPAKSSTSFDFLELN--YSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFE 423

  Fly  1025 HNAQTVVLLSSLDDINFAQFWPDEATPI---ESDHYRVKFLNKTNKSDYVSRDFVIQSIQDD--- 1083
            .       .|:...:|.|..:.:...||   :|..:.:....:|.:.|.......::|...|
Human   424 G-------CSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCF 481

  Fly  1084 YELTV-KMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIE 1147
            .|:.. |::|      :|:....|....|...:..:..|                        ::
Human   482 VEMQAQKVMH------VSSAELNYSLPYDSKHQIRNASN------------------------VK 516

  Fly  1148 MEYCSTANVYQYAKLYHNKRPGVW----------------------------TSSEDIRVIYNIL 1184
            ....|...||.|..|..|.....|                            |||..:...||..
Human   517 HHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSH 581

  Fly  1185 SFL----PGNLNLLKR-------TALRTEFE---DVTTATPDLY------SKICSNVAPLSSSSS 1229
            ..|    |.|::.|..       ||.|.:.|   .:...||:.:      .:...|| |.|.||:
Human   582 DSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNV-PKSLSSA 645

  Fly  1230 -------------TTPPP---------------------------PSTPTPQPPQTIQ------- 1247
                         |:.|.                           .|.|.|.|.:|::
Human   646 VKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADE 710

  Fly  1248 ----------LSSHSPSDLSHQISS--TVANAGSPATASAGATPTTPMTPTV----PPTIPTIPS 1296
                      .|:..|..:.:..||  |:...|...|.|........|..::    ||..|. .|
Human   711 DCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPA-ES 774

  Fly  1297 LASQNSLTLTNANF 1310
            :.|.||.:..|..|
Human   775 VQSNNSSSFLNFGF 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	106/272 (39%)
		PTPc	676..911	CDD:238006	100/242 (41%)
		PTPc	935..1186	CDD:214550	50/320 (16%)
		PTPc	963..1169	CDD:238006	35/233 (15%)
PTPN22	NP_057051.3	PTPc	24..288	CDD:214550	109/286 (38%)
		PTPc	56..288	CDD:238006	100/243 (41%)
		Substrate binding	227..233		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..700		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..746		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810