DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and PTPN20

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001035816.1	Gene:	PTPN20 / 26095	HGNCID:	23423	Length:	420	Species:	Homo sapiens

Alignment Length:	415	Identity:	124/415 - (29%)
Similarity:	192/415 - (46%)	Gaps:	83/415 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 SRIIQLQPNCEKLQPLLRQ-SHNDYNLAVLVGIIFSCFGIILIIMAFF-----------LW-SRK 590
            |::.:.:.|.||::..||. .||||.                   ..|           :| :|.
Human    42 SKVFENKVNSEKVKLSLRNFPHNDYE-------------------DVFEEPSESGSDPSMWTARG 87

  Fly   591 CFHAAYYYLDDP----PHHPNAPQV-DWEVPVKIGD-----EIRAAV-------PVNEFAKHVAS 638
            .|....:..:|.    |....:|.: |....|..|:     :||..:       .:.:..|.:..
Human    88 PFRRDRWSSEDEEAAGPSQALSPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEE 152

  Fly   639 LHADGDIGFSREYEAIQNECISDDLPCEHS--QHPENKRKNRYLNITAYDHSRVHLHPTPGQKKN 701
            ..|..||  .:|:.|::.:    :||.|.:  ..|.|:.||||.:|..||.:||.|    |:.|
Human   153 KTAAYDI--MQEFMALELK----NLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL----GKSK- 206

  Fly   702 LDYINANFIDGYQKG--HAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP 764
             |||||::|.....|  :.:|.|||||..|.|.||:|:.|....:|.|||..:|.|..||..|||
Human   207 -DYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWP 270

  Fly   765 ---KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTP- 825
               |..:|... .:|.|...:::..:.:|..|:      .:|...|...|.|..:|.|||||||
Human   271 ISLKKPLELKH-FRVFLENYQILQYFIIRMFQV------VEKSTGTSHSVKQLQFTKWPDHGTPA 328

  Fly   826 --DHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHI 888
              |..:..:.:.:||..     .||:|||||||:||||.::.:|.:...|.:....|:...:..:
Human   329 SADSFIKYIRYARKSHL-----TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQM 388

  Fly   889 RAQRNFLVQTEEQYIFLHDALVEAI 913
            |.||:.:|||:|||.|.:|.::|.:
Human   389 REQRSGMVQTKEQYHFCYDIVLEVL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	97/274 (35%)
		PTPc	676..911	CDD:238006	90/242 (37%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
PTPN20	NP_001035816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..108		6/39 (15%)
		PTPc	159..411	CDD:214550	98/275 (36%)
		PTPc	185..411	CDD:238006	90/243 (37%)
		Substrate binding. /evidence=ECO:0000250	353..359		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810