DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Ptprz1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	1299	Identity:	393/1299 - (30%)
Similarity:	611/1299 - (47%)	Gaps:	276/1299 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PGVNEHSLVDTLVWKTASTTIAQFANRIPLLH---SPRIQLLSDNFGLQFSPSLASDTSEYICLV 122
            ||::.:|  :..:..|||:.:...:.: |||:   ||      .|......||
  Rat  1150 PGLSTNS--EPALSDTASSEVLHPSTQ-PLLYEAASP------FNTEALLQPS------------ 1193

  Fly   123 NDRHIPEAIVDLLVQD-VPDPPERPLL-----ISFTSRSVNLSWAHSQHPRNAPVTHFIIETREG 181
                .|.:.||.|::. :|..|..|:|     :..:|.|::|..| |:...:....||
  Rat  1194 ----FPASDVDTLLKTALPSGPRDPVLTETPMVEQSSSSMSLPLA-SESASSKSTLHF------- 1246

  Fly   182 EDGIWEQLARIYTKTNATSYQVTGLTPFTVY--SFRLLAVNKLGISPPSKESYYIVTLREAPTGK 244
                             ||..|..::|..|:  |.:.|.|      |.|:|.|:...|.::.:.:
  Rat  1247 -----------------TSVPVLNMSPSDVHPTSLQRLTV------PHSREEYFEQGLLKSKSPQ 1288

  Fly   245 PIPTTAHNTSSTSVYISWKAPPPDTILGEF-----LGYRITYRPRDRDPNDTKEIYIRD--NTVE 302
            .:..:.|:..                  ||     |.....|.|:.|....|..:.|.:  ||:.
  Rat  1289 QVLPSLHSHD------------------EFFQTAHLDISQAYPPKGRHAFATPILSIDEPQNTLI 1335

  Fly   303 SHEIQNLQTYTQYKVTVQVFNPEGLGPETT--ILVMTDEGVPSKPQNLTILDVSAN---SITMS- 361
            |..:.:...:...::::......|| |.|.  :|:.||..||.....:::..||.|   |:|.:
  Rat  1336 SRLVYSEDIFMHPEISITDKALTGL-PTTVSDVLIATDHSVPLGSGPISMTTVSPNRDDSVTTTK 1399

  Fly   362 -----------WHPPKNQNGAIAGYHVFHIHDN----------------------QTGVEIVKNS 393
                       .|..::....:.|......:|:                      :...|.|.|.
  Rat  1400 LLLPSKATSKPTHSARSDADLVGGGEDGDDYDDDDYDDIDSDRFPVNKCMSCSPYRESQEKVMND 1464

  Fly   394 RNSVET--------LIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVG---------- 440
            .::.|:        :.|...:|.........:.:...:.::..|...:.|:.:.|
  Rat  1465 SDTQESSLVDQSDPISHLLSENTEEENGGTGVTRVDKSPDKSPPPSMLPQKHNDGREDRDIQMGS 1529

  Fly   441 -----GPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASA---- 496
                 .|.:.|...||...:..                        :||.|...:..|.::
  Rat  1530 AVLPHTPGSKAWAVLTSDEESG------------------------SGQGTSDSLNDNETSTDFS 1570

  Fly   497 ----KELETAMILQ-----------NLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQP 546
                .|.:...:|:           ..:|.|     |.:....|.|..:......|....|.|..
  Rat  1571 FPDVNEKDADGVLEADDTGIAPGSPRSSTPS-----VTSGHSGVSNSSEAEASNSSHESRIGLAE 1630

  Fly   547 NCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQV 611
            ..|..:..:      ..|.::..:.|.|   :::::...::.||||..|::||:|    ..:|:|
  Rat  1631 GLESEKKAV------IPLVIVSALTFIC---LVVLVGILIYWRKCFQTAHFYLED----NTSPRV 1682

  Fly   612 DWEVPV---KIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQ------NECISD-DLPCE 666
            ....|.   .|.|:| .|:|:..|.||||.|||..  ||:.|:|.::      ..|..| .:..:
  Rat  1683 ISTPPTPIFPISDDI-GAIPIKHFPKHVADLHASN--GFTEEFETLKEFYQEVQSCTVDLGITAD 1744

  Fly   667 HSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNL-DYINANFIDGYQKGHAFIGTQGPLPDTF 730
            .|.||:||.||||:||.|||||||.|.....:...| ||||||::|||.:..|:|..||||..|.
  Rat  1745 SSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTA 1809

  Fly   731 DCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIK 795
            :.|||||||..|.:|||||||||:||||||.|||.||.|.||...|.....:|::.||||...::
  Rat  1810 EDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSEEYGSFLVNQKNVQVLAYYTVRNFTLR 1874

  Fly   796 HLKLKK--KKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVG 858
            :.|:||  :|..::.:||.|||||.|||.|.|::.||||.||:|::.|.....||:|||||||||
  Rat  1875 NTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKTAQAKRHAVGPVVVHCSAGVG 1939

  Fly   859 RTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAE 923
            |||||||||:||:|||.:..||:||||:|||:|||:||||||||:|:||.|||||.|.||.:...
  Rat  1940 RTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDS 2004

  Fly   924 QVEELKNC--------TPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLT 979
            .:....|.        ...||:|::.:.|........::|:||.|..||| .:|.|:|.|||.::
  Rat  2005 HIHSYVNTLLIPGPSGKTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGIS 2069

  Fly   980 PKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ- 1043
            ...|| |:||||||::.|:.:..:||:||||:.|||||||:|:||||||.||::.  |..|.|:
  Rat  2070 SLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP--DGQNMAED 2131

  Fly  1044 ---FWPDEATPIESDHYRVKFLNK-----TNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMS 1100
               :||::..||..:.::|..:::     :|:...:.:||::::.||||.|.|:...||.||...
  Rat  2132 EFVYWPNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPD 2196

  Fly  1101 NP-NSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYH 1164
            :| :..::.|..:.|...: |:||:::.|.:||..|.||||:::|..::|..::.:|||.||:.:
  Rat  2197 SPISKTFELISIIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSMDVYQVAKMIN 2260

  Fly  1165 NKRPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTT------ATPDLYSKICSNVA 1222
            ..||||:|..|..:.:|.:         :|...:.|.|....|:      |.||      .|:|
  Rat  2261 LMRPGVFTDIEQYQFLYKV---------VLSLVSTRQEENPSTSLDSNGAALPD------GNIA 2309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	23/102 (23%)
		fn3	249..331	CDD:278470	15/88 (17%)
		FN3	342..437	CDD:238020	17/139 (12%)
		FN3	442..520	CDD:238020	13/96 (14%)
		PTPc	646..911	CDD:214550	152/274 (55%)
		PTPc	676..911	CDD:238006	141/237 (59%)
		PTPc	935..1186	CDD:214550	98/261 (38%)
		PTPc	963..1169	CDD:238006	84/216 (39%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521		12/119 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622		12/105 (11%)
		PTPc	1717..1992	CDD:214550	152/274 (55%)
		PTPc	1753..1992	CDD:238006	141/238 (59%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		5/5 (100%)
		PTPc	2023..2281	CDD:214550	98/270 (36%)
		PTPc	2051..2281	CDD:238006	90/242 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1192
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1020
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45463
orthoMCL	1	0.900	-	-		OOG6_102521
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1476
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870