Protein Alignment Ptp99A and pyp2

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_594899.1
• Gene: pyp2 / 2542200
• PomBaseID: SPAC19D5.01
• Length: 711
• Species: Schizosaccharomyces pombe
• Alignment Length: 958
• Identity: 198/958 - (20%)
• Similarity: 307/958 - (32%)
• Gaps: 367/958 - (38%)

  Fly    25 ILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRIP 89
            |..:||.....|    .:.|..||.|....||.:....:|...|.|        :::|.. |||.
pombe    45 INVSLPTALLRR----PSFDIGKVFACIKCNVKVSLDEINAIFLYD--------SSMAGM-NRIY 96

  Fly    90 LL--------HSPRIQLLSDNF--------GLQFSPSLASDTSEYICLVNDR------HI--PEA 130
            .|        :|.:|.|||:.|        ....|..:..::..|...:|:.      |:  |.|
pombe    97 DLVQKFRRGGYSKKIYLLSNGFEAFASSHPDAIVSTEMVKESVPYKIDINENCKLDILHLSDPSA 161

  Fly   131 IVDLLVQD----------VPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGI 185
            :...:..|          :|.|...|.::|.|.....   :|:::|
pombe   162 VSTPISPDYSFPLRVPINIPPPLCTPSVVSDTFSEFA---SHAEYP------------------- 204

  Fly   186 WEQLARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTA 250
                            ..:|||||:::|                                 ||.:
pombe   205 ----------------GFSGLTPFSIHS---------------------------------PTAS 220

  Fly   251 HNTSSTSVYISWKAPPPDTILGEFLGYRITYRPR-------DRDPNDTKEIYIRDNTVESHEIQN 308
            ...|..|:|.|..:||......|...:.|:  |.       ...|::.|..:|..|
pombe   221 SVRSCQSIYGSPLSPPNSAFQAEMPYFPIS--PAISCASSCPSTPDEQKNFFIVGN--------- 274

  Fly   309 LQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIA 373
                               .|:.|....:...|||.|.:......||:.:....:..|:.|
pombe   275 -------------------APQQTPARPSLRSVPSYPSSNNQRRPSASRVRSFSNYVKSSN---- 316

  Fly   374 GYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEG--------EPS 430
               |.:...:|..:||:  .|.|::                    :....:|:|        :||
pombe   317 ---VVNPSLSQASLEII--PRKSMK--------------------RDSNAQNDGTSTMTSKLKPS 356

  Fly   431 DQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINAS 495
            ..::...|...|......|..|.::|:                                 :.:..
pombe   357 VGLSNTRDAPKPGGLRRANKPCFNKET---------------------------------KGSIF 388

  Fly   496 AKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHN 560
            :||.:..     .|.|.:...||:                         .|.||.|.
pombe   389 SKENKGP-----FTCNPWGAKKVS-------------------------PPPCEVLA-------- 415

  Fly   561 DYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRA 625
            |.|.|    .||..|
pombe   416 DLNTA----SIFYKF-------------------------------------------------- 426

  Fly   626 AVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRV 690
                    |.:..:.....:.|        |:..||......|:.....|||||.:|..||.:||
pombe   427 --------KRLEEMEMTRSLAF--------NDSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRV 475

  Fly   691 HLHPTPGQKKNLDYINANFID-GYQKGHAFIGTQGPLPDTFDCFWRMIWEQ--RVAIIVMITNLV 752
            .|....|..   |||||:.|| |.:|   :|..|.|.|.|...||.|:|..  ...:|||:|||.
pombe   476 RLAVPKGCS---DYINASHIDVGNKK---YIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLY 534

  Fly   753 ERGRRKCDMYWP--KD-GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQY 814
            |.|..||..|||  || .:...|.:::.:.:.|......|.|    || .:..|.....|.::.:
pombe   535 EAGSEKCSQYWPDNKDHALCLEGGLRISVQKYETFEDLKVNT----HL-FRLDKPNGPPKYIHHF 594

  Fly   815 HYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIV 879
            ....|.|...||  :..:..:.:.....|.: ||:.||||||||||||:|.:|.:|:  ..|||:
pombe   595 WVHTWFDKTHPD--IESITGIIRCIDKVPND-GPMFVHCSAGVGRTGTFIAVDQILQ--VPKNIL 654

  Fly   880 N-----------VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG 916
            .           :|..:..:|:||..:||..||:.||:| :|:.:.||
pombe   655 PKTTNLEDSKDFIFNCVNSLRSQRMKMVQNFEQFKFLYD-VVDYLNSG 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	13/95 (14%)
		FN3	243..337	CDD:238020	17/100 (17%)
		fn3	343..430	CDD:394996	14/94 (15%)
		FN3	442..520	CDD:238020	10/77 (13%)
		R5-PTPc-1	704..907	CDD:350397	75/219 (34%)
		R5-PTP-2	989..1182	CDD:350398
pyp2	NP_594899.1	DSP_MapKP	4..129	CDD:238723	24/96 (25%)
		PHA03247	<159..304	CDD:223021	39/245 (16%)
		PTP_fungal	486..693	CDD:350509	75/219 (34%)