DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_038960209.1	Gene:	Ptpn1 / 24697	RGDID:	61965	Length:	451	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	108/289 - (37%)
Similarity:	176/289 - (60%)	Gaps:	27/289 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 IQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHA 718
            |::|  :.|.||..::.|:||.:|||.:::.:||||:.||    |:.| |||||:.|...:...:
  Rat    42 IRHE--ASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDN-DYINASLIKMEEAQRS 99

  Fly   719 FIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP----KDGVETYGVIQVKLI 779
            :|.||||||:|...||.|:|||:...:||:..::|:|..||..|||    |:.|.....:::.||
  Rat   100 YILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLI 164

  Fly   780 EEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNF---VKKSSAA 841
            .|:|.|.||||.|::::|..::.::      :..:|||.|||.|.|:.|...|||   |::|.:.
  Rat   165 SEDVKSYYTVRQLELENLATQEARE------ILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL 223

  Fly   842 NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQK---NIVNVFGFLRHIRAQRNFLVQTEEQYI 903
            :| |.||||||||||:||:||:.:.|..|..:.::   :.|::...|..:|..|..|:||.:|..
  Rat   224 SP-EHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLR 287

  Fly   904 FLHDALVEA--IASGETNLMAEQVEELKN 930
            |.:.|::|.  ...|::::. :|.:||.:
  Rat   288 FSYLAVIEGAKFIMGDSSVQ-DQWKELSH 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	103/266 (39%)
		PTPc	676..911	CDD:238006	95/244 (39%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Ptpn1	XP_038960209.1	PTPc-N1	38..311	CDD:350456	106/283 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810