DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn7

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006249882.1	Gene:	Ptpn7 / 246781	RGDID:	708516	Length:	405	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	98/244 - (40%)
Similarity:	143/244 - (58%)	Gaps:	19/244 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   671 PENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFW 734
            |.:..|:||..|.....|||.|.....|:.: ||||||:|.||. |...:|.||||:|:|...||
  Rat   163 PGHASKDRYKTILPNPQSRVCLGRAHSQEDS-DYINANYIRGYDGKEKVYIATQGPMPNTVADFW 226

  Fly   735 RMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL 799
            .|:|::.|::|||:|.|.| |:.||..|||.: .|.||..|:::...:....||||.|.|:|
  Rat   227 EMVWQEDVSLIVMLTQLRE-GKEKCVHYWPTE-EEAYGPFQIRIQGMKEHPEYTVRHLTIQH--- 286

  Fly   800 KKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK----SSAANPAEAGPIVVHCSAGVGRT 860
              :::|.:.|.:.   ::.||||.||:...|:|..|.:    .:|||   :||||||||||:|||
  Rat   287 --QQECRSVKHIL---FSAWPDHQTPESAGPLLRLVAEVETPETAAN---SGPIVVHCSAGIGRT 343

  Fly   861 GTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDAL 909
            |.:|......:|::.:..|::.|.:..:|..|..::||.|||.|||..|
  Rat   344 GCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	98/244 (40%)
		PTPc	676..911	CDD:238006	97/239 (41%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
Ptpn7	XP_006249882.1	PTPc	142..393	CDD:214550	98/244 (40%)
Ptpn7	XP_006249882.1	PTPc	168..393	CDD:238006	97/239 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810