DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptprz1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	1290	Identity:	405/1290 - (31%)
Similarity:	619/1290 - (47%)	Gaps:	313/1290 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VDTLVWKTASTTIAQFANRIPLL-HSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHIPEAIV 132
            ||||: |||..::..    .|:| .:|:::..|.:    .|..:||::.....:::...:|  |:
Mouse  1199 VDTLL-KTALPSVPS----DPILAGTPQVEQSSSS----VSHPMASESGSSESMLHFTSVP--IL 1252

  Fly   133 DLLVQDVPDPP--------------ERPLLIS----------------FTSRSVNLSWAHSQHPR 167
            |:....|...|              |:.||.|                |.|..:::|.|:....|
Mouse  1253 DISPSKVHSTPLQGLTVPHSSKKFSEQGLLKSKSPQQVLPSLFSNDEFFQSAHLDVSQAYPPKGR 1317

  Fly   168 NAPVTHFIIETREGEDGIWEQLARIY-------TKTNATSYQVTGLTPFTVYSFRLLAVN---KL 222
            :|.||. ::...|.::.:..:|  :|       |:.:.|...:|||.  |:.|..|.:.:   .|
Mouse  1318 HAFVTP-VLSIDEPQNTLINKL--VYSEDIFSSTEISITDKVLTGLP--TLASDVLSSTDHSVPL 1377

  Fly   223 GISP-------PSKESYYIVTLREAPTGK-PIPTTAHNTSSTSV--------------------Y 259
            |..|       |:::.       ...|.| .:|:||.:..:.|.                    |
Mouse  1378 GSGPISLTMVSPNRDD-------SVTTAKLLLPSTATSKLTQSARSDADLVGGGEDGDDYDDDDY 1435

  Fly   260 ISWKAPPPDTILGEF--------LGYRITYRPRDRDPNDTKEIYIRDNT-------VESHEIQNL 309
                   .|...|.|        |.||.: |.:..:.:||:|..:.|.:       .|:.|.:|
Mouse  1436 -------DDIDRGRFPVNKCMSCLPYRES-REKVMNDSDTQESSLVDQSDPISPLLFENTEEEN- 1491

  Fly   310 QTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSK--PQN----LTILDVSANSITMSWHPPKNQ 368
                           .|.|     :...|:..|..  |||    ....|:...|..:. |.|.::
Mouse  1492 ---------------GGTG-----VTRVDKSPPPSMLPQNHNDGKEDSDIQMGSAVLP-HTPGSK 1535

  Fly   369 NGAIAGYHVFHIHDNQTGV-EIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQ 432
            ..|:.      ..|.::|. :...:|.|..||           .||:     :|...|| :.:|.
Mouse  1536 AWAVL------TSDEESGSGQGTSDSLNDNET-----------STDF-----SFPDVNE-KDTDG 1577

  Fly   433 IAQRTDVG-GPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASA 496
            :.:..|.| .|.:|.      .|..|:|                         ..|..:. |:|.
Mouse  1578 VLETDDTGIAPGSPR------SSTPSVT-------------------------SGHSGVS-NSSE 1610

  Fly   497 KELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHND 561
            .|          .:||.:|.::..|. .:.:.||.|:                   ||:
Mouse  1611 AE----------ASNSSHESRIGLAE-GLESEKKAVI-------------------PLV------ 1639

  Fly   562 YNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPV---KIGDEI 623
                ::..:.|.|   :::::...::.||||..|::||:|    ..:|:|....|.   .|.|:|
Mouse  1640 ----IVSALTFIC---LVVLVGILIYWRKCFQTAHFYLED----NTSPRVISTPPTPIFPISDDI 1693

  Fly   624 RAAVPVNEFAKHVASLHADGDIGFSREYEAIQ------NECISD-DLPCEHSQHPENKRKNRYLN 681
             .|:|:..|.||||.|||..  ||:.|:|.::      ..|.:| .:..:.|.||:||.||||:|
Mouse  1694 -GAIPIKHFPKHVADLHASN--GFTEEFETLKEFYQEVQSCTADLGITADSSNHPDNKHKNRYVN 1755

  Fly   682 ITAYDHSRVHLHPTPGQKKNL-DYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAII 745
            |.|||||||.|.....:...| ||||||::|||.:..|:|..||||..|.:.|||||||..|.:|
Mouse  1756 IVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVI 1820

  Fly   746 VMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKK--------K 802
            ||||||||:||||||.|||.||.|.||...|.....:|::.||||...:::.||||        :
Mouse  1821 VMITNLVEKGRRKCDQYWPTDGSEEYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKLSELFQGSQ 1885

  Fly   803 KQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD 867
            |..::.:||.|||||.|||.|.|::.||||.||:|::.|.....||:||||||||||||||||||
Mouse  1886 KGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKAAQAKRHAVGPVVVHCSAGVGRTGTYIVLD 1950

  Fly   868 AMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNC- 931
            :||:|||.:..||:||||:|||:|||:||||||||:|:||.|||||.|.||.:....:....|.
Mouse  1951 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTL 2015

  Fly   932 -------TPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSD 988
                   ...||:|::.:.|........::|:||.|..||| .:|.|:|.|||.::...|| |:|
Mouse  2016 LIPGPTGKTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTD 2079

  Fly   989 YINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQ----FWPDEA 1049
            |||||::.|:.:..:||:||||:.|||||||:|:||||||.||::.  |..|.|:    :||::.
Mouse  2080 YINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP--DGQNMAEDEFVYWPNKD 2142

  Fly  1050 TPIESDHYRVKFLNK-----TNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP-NSIYDF 1108
            .||..:.::|..:::     :|:...:.:||::::.||||.|.|:...||.||...:| :..::.
Mouse  2143 EPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFEL 2207

  Fly  1109 IVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTS 1173
            |..:.|...: |:||:::.|.:||..|.||||:::|..::|..:..:|||.||:.:..||||:|.
Mouse  2208 ISIIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENAMDVYQVAKMINLMRPGVFTD 2271

  Fly  1174 SEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTT------ATPDLYSKICSNVA 1222
            .|..:.:|.:         :|...:.|.|....|:      |.||      .|:|
Mouse  2272 IEQYQFLYKV---------VLSLVSTRQEENPSTSLDSNGAALPD------GNIA 2311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	28/142 (20%)
		fn3	249..331	CDD:278470	20/116 (17%)
		FN3	342..437	CDD:238020	21/101 (21%)
		FN3	442..520	CDD:238020	12/77 (16%)
		PTPc	646..911	CDD:214550	153/280 (55%)
		PTPc	676..911	CDD:238006	142/243 (58%)
		PTPc	935..1186	CDD:214550	98/261 (38%)
		PTPc	963..1169	CDD:238006	84/216 (39%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1714..1997	CDD:391942	155/282 (55%)
		R-PTP-Z-2	2080..2283	CDD:350507	77/214 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1224
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43393
orthoMCL	1	0.900	-	-		OOG6_102521
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810