Protein Alignment Ptp99A and Ptprb

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_036011586.1
• Gene: Ptprb / 19263
• MGIID: 97809
• Length: 2361
• Species: Mus musculus
• Alignment Length: 1106
• Identity: 260/1106 - (23%)
• Similarity: 439/1106 - (39%)
• Gaps: 283/1106 - (25%)

  Fly    28 TLPATQAGRIFDVTNLDYVKVNAEAGKNVTI---PCPGV---------NEHSLVDTLVWKTASTT 80
            |:||:..|         .|..||.:..::|:   ...||         ||:.|:.:.|.:.|:..
Mouse  1281 TVPASVQG---------VVAANAYSSNSLTVSWQKALGVAERYDILLLNENGLLLSNVSEPATAR 1336

  Fly    81 IAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHIPEAIVDLLVQDVPDPPER 145
            ..:|.:..| ....::|:|:.:.||....|.|          ..|.:|.|:.:|   .:.:...|
Mouse  1337 QHKFEDLTP-GKKYKMQILTVSGGLFSKESQA----------EGRTVPAAVTNL---RITENSSR 1387

  Fly   146 PLLISFTSRSVNLSW-----------------------------------------AHSQHPRN- 168
            .|...:|:....|||                                         .||....|
Mouse  1388 YLSFGWTASEGELSWYNIFLYNPDRTLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNE 1452

  Fly   169 ---------APVTHFIIETREGEDGIW----------EQLARIYTKTNATSYQVTGLTPFTVYSF 214
                     |.|.|.....|...|.:|          :....|....|.|..:.......|.:.|
Mouse  1453 SFIFGRTVPAAVNHLKGSHRNTTDSLWFSWSPASGDFDFYELILYNPNGTKKENWKEKDVTEWRF 1517

  Fly   215 RLLAVNKLGISPPSKESYYIVT----LREAPTGK----PIPTTA---HNTSSTSVYISWKAPPPD 268
            :       |:.|..|.:.|:||    |....||:    |.|.:.   .:.::||:.|:||.||..
Mouse  1518 Q-------GLVPGRKYTLYVVTHSGDLSNKVTGEGRTAPSPPSLLSFADVANTSLAITWKGPPDW 1575

  Fly   269 TILGEFLGYRITYRPRDR----DPNDTKEIYIRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGP 329
            |   ::..:.:.:.|.|.    :|..:::       .|...:..|.....|:.:|:..:.:....
Mouse  1576 T---DYNDFELQWFPGDALTIFNPYSSRK-------SEGRIVYGLHPGRSYQFSVKTVSGDSWKT 1630

  Fly   330 ETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSR 394
            .:..:..:....|.|.|||.....::.:|..||.||.:.      :..:.|...:...:.::.||
Mouse  1631 YSKPISGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSD------FDGYSIECRKMDTQEIEFSR 1689

  Fly   395 NSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQR--TDVGGPSAP------------ 445
            ...:......:..|.|:..|.|.:|   .::.|..|:.:...  |.:..|..|
Mouse  1690 KLEKEKSLLNIMMLVPHKRYLVSIK---VQSAGMTSEVVEDSTITMIDRPPQPPPHIRVNEKDVL 1751

  Fly   446 ---AIVNLTCHSQESITIRWRRPYEFYNT---IDFYIIKTRLAGQ------------DTHRDIRI 492
               :.:|.|      :...|     |.:|   :.::.:..|.|..            .::.:.|.
Mouse  1752 ISKSSINFT------VNCSW-----FSDTNGAVKYFAVVVREADSMDELKPEQQHPLPSYLEYRH 1805

  Fly   493 NASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKL--QPLL 555
            |||.:..:|          :|:..|.|.:..|......|.||...:|...:..|:.:|.  .||
Mouse  1806 NASIRVYQT----------NYFASKCAESPDSSSKSFNIKLGAEMDSLGGKCDPSQQKFCDGPL- 1859

  Fly   556 RQSHNDYNLAV----------------------------------LVGII------FSCFGIILI 580
             :.|..|.:::                                  |.|:|      ....|:::.
Mouse  1860 -KPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSMPITTESEPLFGVIEGVSAGLFLIGMLVA 1923

  Fly   581 IMAFFLWSRKCFHAAYYYLDDPPHHPNAP---------QVDWEVPVKIGDEIRAAVPVNEFAKHV 636
            ::|||:..:|..|:.        ..|:|.         .|...:..|...:....:.:|:|..|.
Mouse  1924 LVAFFICRQKASHSR--------ERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHF 1980

  Fly   637 ASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKN 701
            ..|.||.:...|:|||.:::  :.....|:.:..|||:.||||.||..||.|||.|........:
Mouse  1981 MKLQADSNYLLSKEYEDLKD--VGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDPCS 2043

  Fly   702 LDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD 766
             |||||::|.|......:|.||||||.|.|.||:|.|||.|..|||:|..||:||.|||.|||.|
Mouse  2044 -DYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPAD 2107

  Fly   767 GVET-YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLP 830
            .... ||.:.::::.|.|:..:|:|     ..|:..::|.:..:|:..:|||.|||||.|:....
Mouse  2108 QDPLYYGDLILQMVSESVLPEWTIR-----EFKICSEEQLDAHRLIRHFHYTVWPDHGVPETTQS 2167

  Fly   831 VLNFVK--KSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRN 893
            ::.||:  :........|||.|||||||||||||::.||.:|:|:..|:.|:::|.:..:|..|.
Mouse  2168 LIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRV 2232

  Fly   894 FLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQ------YKNIIQFQPKDIHI 952
            .:||||.||::||..:.:.:          :.::|:|     ||:      |:|:.....:.:|:
Mouse  2233 HMVQTECQYVYLHQCVRDVL----------RAKKLRN-----EQENPLFPIYENVNPEYHRALHV 2282

  Fly   953 A 953
            |
Mouse  2283 A 2283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	24/156 (15%)
		FN3	243..337	CDD:238020	18/104 (17%)
		fn3	343..430	CDD:394996	18/86 (21%)
		FN3	442..520	CDD:238020	16/107 (15%)
		R5-PTPc-1	704..907	CDD:350397	89/205 (43%)
		R5-PTP-2	989..1182	CDD:350398
Ptprb	XP_036011586.1	beta-trefoil_Ricin_MRC-like	18..133	CDD:483961
		Herpes_BLLF1	<158..>352	CDD:282904
		FN3	<370..>545	CDD:442628
		FN3	398..483	CDD:238020
		fn3	579..658	CDD:394996
		fn3	681..742	CDD:394996
		fn3	757..835	CDD:394996
		FN3	856..1309	CDD:442628	8/36 (22%)
		FN3	<1341..1674	CDD:442628	67/369 (18%)
		fn3	1550..1632	CDD:394996	16/91 (18%)
		fn3	1644..1723	CDD:394996	18/87 (21%)
		PTP_tm	1761..1898	CDD:465889	24/153 (16%)
		R-PTPc-B	2019..2246	CDD:350465	101/232 (44%)