Protein Alignment Ptp99A and Ptpra

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_036015592.1
• Gene: Ptpra / 19262
• MGIID: 97808
• Length: 838
• Species: Mus musculus
• Alignment Length: 931
• Identity: 271/931 - (29%)
• Similarity: 430/931 - (46%)
• Gaps: 184/931 - (19%)

  Fly   317 VTVQVFNPEGLGPE--TTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFH 379
            :.|...|...:.|.  ||.|:.|.....:|.:|.| .:.:::.|::|..|..:.|..:...:|..
Mouse    15 IHVSANNATTVSPSLGTTRLIKTSTTELAKEENKT-SNSTSSVISLSVAPTFSPNLTLEPTYVTT 78

  Fly   380 IH----DNQT---------GVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSD 431
            ::    ||.|         |..|..|....:|          ..:||      |.|...||..|
Mouse    79 VNSSHSDNGTRRAASTESGGTTISPNGSWLIE----------NQFTD------AITEPWEGNSS- 126

  Fly   432 QIAQRTDVGGPSA-----------PAIVNLTCHSQESITIRW-RRPYEFYNTIDFYIIKTRLAGQ 484
             .|..|....|.|           |:...:.||...:.:..| ..|    |.|.
Mouse   127 -TAATTPETFPPAGMARGLPSHQEPSHSYIACHRMTAFSSAWAHSP----NVIS----------- 175

  Fly   485 DTHRDIRINASAKEL--ETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPN 547
                    |:.:|:.  ||.:|          .|.||.:
Mouse   176 --------NSDSKDRRDETPII----------AVMVALS-------------------------- 196

  Fly   548 CEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLD-------DPPHH 605
                           :|.|:|.||     |:|.::.|..:.:...|:..:.|.       :|...
Mouse   197 ---------------SLLVIVFII-----IVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV 241

  Fly   606 P---NAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLP--- 664
            |   .:|..:.:.|         .:||::..:.:....||.:..|..|:.|         ||
Mouse   242 PLLARSPSTNRKYP---------PLPVDKLEEEINRRMADDNKLFREEFNA---------LPACP 288

  Fly   665 ----CEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGP 725
                ||.:...|||.||||:||..||||||||.|..|...: |||||:||:|||:.:.||..|||
Mouse   289 IQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDS-DYINASFINGYQEKNKFIAAQGP 352

  Fly   726 LPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVR 790
            ..:|.:.||||||||..|.|||:|||.||...||..|||..|..|||.::|.:.:..|:..||||
Mouse   353 KEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVR 417

  Fly   791 TLQIKHL-KLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCS 854
            ...|:.: .:..:|   .::|:.|:|:|:|||.|.|..|:.:|.|:||..|.||..||.||||||
Mouse   418 KFCIQQVGDVTNRK---PQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCS 479

  Fly   855 AGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETN 919
            ||||||||::|:||||..:..:..|:|:||:..|||||..:|||:.||:|::.||:|....|:|.
Mouse   480 AGVGRTGTFVVIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE 544

  Fly   920 L----MAEQVEELKNCTP-----YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGS 974
            |    :...::::.|..|     .||:::|.:...:.::..:.:.....|..|||. .|.|.|.:
Mouse   545 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN 609

  Fly   975 RVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD- 1038
            ||.:..|.||:.:||:|||::.|:|:...:|.:|.|:.|||:|||:|:|:..:.::|:|:.|::
Mouse   610 RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER 674

  Fly  1039 --INFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSN 1101
              ...||:||.:......| ..|:...:.....|..||.::.:.:::....::..|...|||:..
Mouse   675 GQEKCAQYWPSDGLVSYGD-ITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGI 738

  Fly  1102 PN---SIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLY 1163
            |:   .:.:.|..|.::.....|.||.:....|..:..||||:|::...::.....:|:|..|..
Mouse   739 PSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSL 803

  Fly  1164 HNKRPGVWTSSEDIRVIYNIL 1184
            ..:||.:..:.|.....|.::
Mouse   804 RLQRPHMVQTLEQYEFCYKVV 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020	6/21 (29%)
		fn3	343..430	CDD:394996	21/99 (21%)
		FN3	442..520	CDD:238020	16/91 (18%)
		R5-PTPc-1	704..907	CDD:350397	102/203 (50%)
		R5-PTP-2	989..1182	CDD:350398	51/198 (26%)
Ptpra	XP_036015592.1	R-PTPc-A-1	250..545	CDD:350469	139/316 (44%)
		R-PTPc-A-2	599..826	CDD:350471	62/227 (27%)