DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp99A and Ptpn22

DIOPT Version :10

Sequence 1:NP_651691.4 Gene:Ptp99A / 43469 FlyBaseID:FBgn0004369 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_033005.1 Gene:Ptpn22 / 19260 MGIID:107170 Length:802 Species:Mus musculus


Alignment Length:857 Identity:205/857 - (23%)
Similarity:312/857 - (36%) Gaps:273/857 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   631 EFAKHVASLHADGDIGFSREYEAIQNECISDDL-PCEHSQHPENKRKNRYLNITAYDHSRVHLHP 694
            |||.....|...     |.:|:|       |.: |...:|.|:|.:||||.:|..||||.|.|..
Mouse    23 EFASEFLKLKRQ-----STKYKA-------DKIYPTTVAQRPKNIKKNRYKDILPYDHSLVELSL 75

  Fly   695 TPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKC 759
            ....:.: .||||:||.|.....|:|.|||||..|...|||||||.|:.:|||.....|.|::||
Mouse    76 LTSDEDS-SYINASFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYRILVIVMACMEFEMGKKKC 139

  Fly   760 DMYWPKDGVET---YGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPD 821
            :.||.:.| ||   :|...:....|:..|.|.:|||        |.|..|..:::||:||.||||
Mouse   140 ERYWAEPG-ETQLQFGPFSISCEAEKKKSDYKIRTL--------KAKFNNETRIIYQFHYKNWPD 195

  Fly   822 HGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD---AMLKQ-IQQKNIVNVF 882
            |..|....|:|..:.........:..||.:|||||.||||....:|   .:||. |..||. :||
Mouse   196 HDVPSSIDPILQLIWDMRCYQEDDCVPICIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNF-SVF 259

  Fly   883 GFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASG----ETNLMAEQVEELKNCT-PYLEQQYKNI 942
            ..::.:|.||..||||:|||..::.|::|.....    ..|.:..:::  ..|: |  ||.....
Mouse   260 NLIQEMRTQRPSLVQTQEQYELVYSAVLELFKRHMDVISDNHLGREIQ--AQCSIP--EQSLTVE 320

  Fly   943 IQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDY------INAS---WLHGF 998
            ....|.|:. .:||:.|.:......    :|:....|     .||..      :||.   .||..
Mouse   321 ADSCPLDLP-KNAMRDVKTTNQHSK----QGAEAEST-----GGSSLGLRTSTMNAEEELVLHSA 375

  Fly   999 RRLRDF-------------IVTQHPMA------------HTIKDFWQMVWD-------------- 1024
            :....|             ::|::..|            :...||..|::.              
Mouse   376 KSSPSFNCLELNCGCNNKAVITRNGQARASPVVGEPLQKYQSLDFGSMLFGSCPSALPINTADRY 440

  Fly  1025 HNAQTVVLLSSLDDINFAQFWPDEATPIE-----------------------SDHYRVKFLNKTN 1066
            ||::..|..:             ::||.|                       .:||.::.| :..
Mouse   441 HNSKGPVKRT-------------KSTPFELIQQRKTNDLAVGDGFSCLESQLHEHYSLREL-QVQ 491

  Fly  1067 KSDYVSRDFVIQSIQDDYELTVKMLHCPS--------------WPEMSNPNSI-----YDFIVDV 1112
            :..:||.:.:..|:....:.:....|.|.              :...|.|||.     :|     
Mouse   492 RVAHVSSEELNYSLPGACDASCVPRHSPGALRVHLYTSLAEDPYFSSSPPNSADSKMSFD----- 551

  Fly  1113 HERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDI 1177
                         :.::..||        :|....:...||.:.:             :::..|.
Mouse   552 -------------LPEKQDGA--------TSPGALLPASSTTSFF-------------YSNPHDS 582

  Fly  1178 RVIYNILSFLPGNLNLLKRTAL-----RTEFE---DVTTATPDLY-------------------- 1214
            .|:..:.||.|   .|.:.||:     ||:.|   .:...||:.:                    
Mouse   583 LVMNTLTSFSP---PLNQETAVEAPSRRTDDEIPPPLPERTPESFIVVEEAGEPSPRVTESLPLV 644

  Fly  1215 -----SKICSNVAPLSSSSST--TP------------------PPPSTPTPQ------------- 1241
                 |..||..:.:.|..|.  ||                  |||  |.|:             
Mouse   645 VTFGASPECSGTSEMKSHDSVGFTPSKNVKLRSPKSDRHQDGSPPP--PLPERTLESFFLADEDC 707

  Fly  1242 -PPQTIQLSSHS-PSDLSHQISS--TVANAGSPATASAGATPTTPMTPTV----PPTIPTIPSLA 1298
             ..|.:|.||.| |....:..||  |:...|...|.|........|..:|    .|:.|| ..:.
Mouse   708 IQAQAVQTSSTSYPETTENSTSSKQTLRTPGKSFTRSKSLKIFRNMKKSVCNSSSPSKPT-ERVQ 771

  Fly  1299 SQNSLTLTNANF 1310
            .:||.:..|..|
Mouse   772 PKNSSSFLNFGF 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp99ANP_651691.4 FN3 140..236 CDD:238020
FN3 243..337 CDD:238020
fn3 343..430 CDD:394996
FN3 442..520 CDD:238020
R5-PTPc-1 704..907 CDD:350397 86/209 (41%)
R5-PTP-2 989..1182 CDD:350398 36/282 (13%)
Ptpn22NP_033005.1 PTPc-N22 57..290 CDD:350450 99/243 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..358 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..564 8/53 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..619 5/21 (24%)
Interaction with CSK. /evidence=ECO:0000269|PubMed:8890164 613..621 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..695 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..802 20/72 (28%)
Blue background indicates that the domain is not in the aligned region.

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